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Study reveals new clues to help understand brain stimulation

Posted: Published on September 30th, 2014

PUBLIC RELEASE DATE: 29-Sep-2014 Contact: Bonnie Prescott bprescot@bidmc.harvard.edu 617-667-7306 Beth Israel Deaconess Medical Center @BIDMChealth BOSTON Over the past several decades, brain stimulation has become an increasingly important treatment option for a number of psychiatric and neurological conditions. Divided into two broad approaches, invasive and noninvasive, brain stimulation works by targeting specific sites to adjust brain activity. The most widely known invasive technique, deep brain stimulation (DBS), requires brain surgery to insert an electrode and is approved by the U.S. Food and Drug Administration (FDA) for the treatment of Parkinson's disease and essential tremor. Noninvasive techniques, including transcranial magnetic stimulation (TMS), can be administered from outside the head and are currently approved for the treatment of depression. Brain stimulation can result in dramatic benefit to patients with these disorders, motivating researchers to test whether it can also help patients with other diseases. But, in many cases, the ideal sites to administer stimulation have remained ambiguous. Exactly where in the brain is the best spot to stimulate to treat a given patient or a given disease? Now a new study in the Proceedings of the National Academy of Sciences (PNAS) helps answer this question. Led by investigators at Beth Israel Deaconess … Continue reading

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Computer models help cerebral palsy patients step out

Posted: Published on September 30th, 2014

University of Queensland researchers are using computer modelling to predict the most effective way to help cerebral palsy patients walk and move more easily. Dr Glen Lichtwark from the Centre for Sensorimotor Performance at UQs School of Human Movement Studies is simulating and predicting how surgery, strength training and other treatments could improve patients muscle function. The project will examine the effectiveness of medical interventions on muscle development and function, Dr Lichtwark said. Cerebral palsy affects parts of the brain that control movement, therefore affecting a persons posture and muscle coordination. Patients often need medical treatment and surgery to maintain mobility and manage muscle weakness, spasticity, joint stiffness and reduced muscle control. What we really want to know is how a specific treatment might impact an individual, so treatments can be tailored to that individual to maximise treatment success. About 34,000 people are living with cerebral palsy in Australia and this is expected to rise to more than 47,000 by 2050. Dr Lichtwark said previously it had been difficult to establish the impact surgery had on walking, or to determine which treatments would address specific impairments. Our researchers have begun developing models to examine the impact of muscle tightening and … Continue reading

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North American Seminars Presents Traumatic Brain Injury and Concussions in Conduction with St. Anthony's Medical …

Posted: Published on September 30th, 2014

Franklin, TN (PRWEB) September 30, 2014 This two-day, advanced PT continuing education course seminar focusing on balance and vestibular sequellae that may arise following a concussion or mild traumatic brain injury (mTBI). The cause of concussions can be varied, from sports related injuries, car accidents, falls, to the more unique and complex mTBI sustained by the thousands of returning soldiers from war zone regions. While at first glance, it appears that blast and blunt traumas can result in similar injuries, the course will emphasize the differences present. This PT Vestibular CME course is designed to aid in the identification of vestibular and balance deficits following a concussion. The participant will learn what types of diagnoses are most common following a concussion, expected recovery, outcomes and prognosis. We will cover a variety of pathologies including diffuse axonal injury, skull fractures, complex cases of BPPV, vestibular loss, cranial nerve damage, fistulas, traumatic Menieres, whiplash, motion intolerance, exercise induced dizziness and balance dysfunctions. We will discuss current return to play guidelines, their limitations and how balance plays an important role. Case studies will be introduced so that participants will learn to systematically approach the examination, establish a working diagnosis and develop treatment plan … Continue reading

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Cells from placentas safe for patients with multiple sclerosis, study shows

Posted: Published on September 30th, 2014

Patients with Multiple Sclerosis (MS) were able to safely tolerate treatment with cells cultured from human placental tissue, according to a study published today in the journal Multiple Sclerosis and Related Disorders. The study, which is the first of its kind, was conducted by researchers at Mount Sinai, Celgene Cellular Therapeutics subsidiary of Celgene Corporation and collaborators at several other institutions. While designed to determine safety of the treatment, early signals in the data also suggested that a preparation of cultured cells called PDA-001 may repair damaged nerve tissues in patients with MS. PDA-001 cells resemble "mesenchymal," stromal stem cells found in connective tissue in bone marrow, but unlike their bone-marrow derived counterparts, stromal cells from the placenta are more numerous, with one donor able to supply enough cells for many patients. "This is the first time placenta-derived cells have been tested as a possible therapy for multiple sclerosis," said Fred Lublin, MD, Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Professor of Neurology at Icahn School of Medicine at Mount Sinai and the lead investigator of the study. "The next step will be to study larger numbers of MS patients to assess efficacy of the cells, but … Continue reading

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Cells From Placentas Safe for Patients with Multiple Sclerosis

Posted: Published on September 30th, 2014

Contact Information Available for logged-in reporters only Newswise (NEW YORK September 29, 2014) Patients with Multiple Sclerosis (MS) were able to safely tolerate treatment with cells cultured from human placental tissue, according to a study published today in the journal Multiple Sclerosis and Related Disorders. The study, which is the first of its kind, was conducted by researchers at Mount Sinai, Celgene Cellular Therapeutics subsidiary of Celgene Corporation and collaborators at several other institutions. While designed to determine safety of the treatment, early signals in the data also suggested that a preparation of cultured cells called PDA-001 may repair damaged nerve tissues in patients with MS. PDA-001 cells resemble mesenchymal, stromal stem cells found in many tissues of the body. Since the cells are expanded in cell cultures, one donor is able to supply enough cells for many patients. This is the first time placenta-derived cells have been tested as a possible therapy for multiple sclerosis, said Fred Lublin, MD, Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Professor of Neurology at Icahn School of Medicine at Mount Sinai and the lead investigator of the study. The next step will be to study larger numbers of MS patients … Continue reading

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Judge orders brain-damaged toddler to be removed from life-support machine despite Christian parents' desperate pleas …

Posted: Published on September 30th, 2014

High Court judge orders brain damaged child's life support to be turned off Judge said it was in the child's best interests for the care to be withdrawn His parents disagreed, saying no-one had right to remove 'privilege'of life Judge: 'It is their belief that given time God may work a miracle' A failure in the boy's treatment was also referred to during court hearings The parties involved in the case are unable to be identified for legal reasons By Corey Charlton for MailOnline Published: 07:27 EST, 30 September 2014 | Updated: 07:29 EST, 30 September 2014 A High Court judge today ruled that a little boy with brain damage should be taken off a life-support machine despite his parents' pleas to keep him alive. Specialists had told Ms Justice Russell that the youngster - who turned one earlier this year - had suffered irreversible brain damage and it was in the youngster's best interests for live-sustaining care to be withdrawn. However, the boy's devout Christian parents - who cannot be identified for legal reasons - disagreed. Today the youngster's father said no-one had the right to take away the 'privilege' of life from his son. In words that echoed … Continue reading

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Durham science firm bought by Japanese giant

Posted: Published on September 30th, 2014

A NORTH-East science firm has been bought up by a Japanese stem cell company, offering hope for the development of better heart, liver and nerve cells. Reinnervate Ltd, a Durham University off-shoot which markets Alvetex a polystyrene material said to be an ideal base for growing cells into 3D structures has been bought by Reprocell, one of the worlds leading suppliers of stem cells human cells that can develop into different cell types. The Yokohama-based firm has agreed to invest in further research in the universitys laboratories into so-called scaffolding structures that support 3D cell growth. It intends to invest in research facilities and research studentships and combine its own work that that of Reinnervate to create cutting-edge tools for drug toxicity testing, neuroscience and cancer research. Reinnervate chief executive Richard Rowling said: We are delighted to become part of the Reprocell group of companies and look forward to seeing Alvetex products combined with Reprocells advanced stem cell derived cell products. Reinnervate is based at NetPark, near Sedgefield, County Durham. Next year, Alvetex 3D cell culture technology will be taken to the International Space Station for an experiment in growing bone culture in zero gravity to investigate bone density during … Continue reading

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Pitt Researchers Search for Genetic Roots of Cleft Lip, Palate with Help from NIH Grant

Posted: Published on September 30th, 2014

Pittsburgh, Pennsylvania (PRWEB) September 30, 2014 Researchers at the University of Pittsburgh School of Dental Medicine have been awarded a $11.8 million, five-year grant from the National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, to continue their exploration of the genetic roots of cleft lip and cleft palate and to expand the effort to include populations in Colombia, Nigeria, the Philippines and Pennsylvania. Orofacial clefts (OFCs), which are small gaps in the lip or palate that can form when a babys mouth doesnt develop properly during pregnancy, occurs in 1 out of 700 live births worldwide, said Mary L. Marazita, Ph.D., professor and vice chair, Department of Oral Biology, and director of the Center for Craniofacial and Dental Genetics (CCDG). Orofacial clefts present a significant public health challenge as these patients typically require surgical, nutritional, dental, speech and behavioral treatments for years, Dr. Marazita said. We hope to build on the progress weve made in our previous studies by identifying genetic susceptibility not only for the overt defects, but also for more subtle features such as changes in facial structure that we have found in relatives of participants with OFCs. Dr. Marazita and Seth … Continue reading

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Genetic test would help 'cut bowel cancer spread'

Posted: Published on September 30th, 2014

PUBLIC RELEASE DATE: 30-Sep-2014 Contact: Chris Jones jonesc83@cardiff.ac.uk Cardiff University @cardiffuni Screening families of patients with bowel cancer for a genetic condition would cut their risk of developing bowel, womb, and ovarian cancers, new research has found. In a major study, Dr Ian Frayling from Cardiff University's School of Medicine and researchers from the University of Exeter's Medical School assessed the effectiveness of introducing a UK-wide screening programme for a genetic condition known as Lynch Syndrome. Lynch syndrome is a caused by changes in genes which check the spelling in DNA. The condition increases the risk of people developing cancer, particularly bowel cancer and cancers of the womb and ovaries later in life. Without testing cancers, it is not obvious that they are caused by Lynch syndrome, and so it is often not diagnosed. It is responsible for around one in 12 cases of people aged under 50 and around a third of people with the disease develop bowel cancer by the time they are 70, if no action is taken. "If Lynch Syndrome is identified as the cause of bowel cancer, patients can be offered risk-reducing measures such as more intensive post-operative colonoscopy surveillance to spot recurrences and new … Continue reading

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Stem Cell Therapy The Aspen Institute for Anti Aging & Regenerative Medicine – Video

Posted: Published on September 30th, 2014

Stem Cell Therapy The Aspen Institute for Anti Aging Regenerative Medicine By: Cupio Media … Continue reading

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