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Biochemists solve 'address problem' in cells that leads to lethal kidney disease

Posted: Published on September 27th, 2014

Research by UCLA biochemists may lead to a new treatment -- or even a cure -- for PH1, a rare and potentially deadly genetic kidney disease that afflicts children. Their findings also may provide important insights into treatments for Parkinson's disease, Alzheimer's disease and other degenerative diseases. Led by Carla Koehler, a professor of chemistry and biochemistry in the UCLA College, the researchers identified a compound called dequalinium chloride, or DECA, that can prevent a metabolic enzyme from going to the wrong location within a cell. Ensuring that the enzyme -- called alanine: glyoxylate aminotransferase, or AGT -- goes to the proper "address" in the cell prevents PH1. The findings were published online in the Proceedings of the National Academy of Sciences and will appear later in the journal's print edition. In humans, AGT is supposed to go to an organelle inside the cell called the peroxisome, but for people with a particular genetic mutation, the enzyme mistakenly goes instead to the mitochondria -- tiny power generators in cells that burn food and produce most of the cells' energy -- which causes PH1. Koehler's team demonstrated that adding small amounts of DECA, which is FDA-approved, to cells in a Petri … Continue reading →

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Common Curry Ingredient Could Help The Brain Battle The Affects Of Alzheimers

Posted: Published on September 27th, 2014

September 27, 2014 Chuck Bednar for redOrbit.com Your Universe Online Eating spicy Indian food could help boost the brains ability to heal itself, according to new research published in Fridays edition of the journal Stem Cell Research and Therapy. According to Damian Gayle of The Daily Mail, aromatic turmerone, a compound found in the popular curry spice turmeric, could encourage the growth of nerve cells believed to help repair the brains of those suffering from neurodegenerative conditions such as dementia or Alzheimers disease. In lab tests involving rats, researchers from the Institute of Neuroscience and Medicine (INM-3) in Germany, the University Hospital of Cologne Department of Neurology and the Max Planck Institute for Neurological Research found that aromatic turmerone promoted the proliferation of brain stem cells and their development into neurons. The study authors believe it could help scientists develop new ways to treat conditions that kill brain cells, which include strokes and Alzheimers. However, they told BBC News health reporter Smitha Mundasad that additional trials are required to see if the affect is applicable to humans. The researchers injected the rodents with the compound, and then scanned their brains, Mundasad explained. They found that activity increased in the regions … Continue reading →

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Stem Cell Therapy in Muscular Dystrophy – Man – Video

Posted: Published on September 27th, 2014

Stem Cell Therapy in Muscular Dystrophy - Man stem cell india, stem cell therapy india, stem cell in india, stem cell therapy in india, india stem cell, india stem cell therapy. By: Stem Cell India … Continue reading →

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Fat Stem Cell Therapy | Medical Treatments Cosmetic Procedures

Posted: Published on September 27th, 2014

AUTOLOGOUS Adipose Stem Cells Stem Cell Therapy is not a new technology. As a matter of fact it has been around for more that 60 years now. The problem is most people know it as a bone marrow transplant. And well when you finish saying that people are already screaming "That's Painful". A bone marrow transplant essentially extracts stem cells from your own bone marrow and then returns them back to you. It has been used to help people suffering from conditions like Leukemia and Lymph Node Cancer. How does it work? Stem Cells hone in on "chemokine" signals that are secreted by injury. When they arrive they alert regenerative cells to go to work and repair the damage, or grow tissue. At birth, the human body has around 80 million active stem cells working. At age 40 we have less than 25 million active stem cells working. Therefore it takes longer for the body to heal and in some cases damage is often ignored. This is the aging or degeneration process of the body. In 1998 a little known about Bio Tech Company discovered that there was an enormous amount of stem cells in abdominal fat, commonly referred to … Continue reading →

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Epithelial-mesenchymal transition, cancer stem cells and …

Posted: Published on September 27th, 2014

Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, Mandelblatt JS, Yakovlev AY, Habbema JD, Feuer EJ: Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 2005, 353:1784-1792. PubMedAbstract | PublisherFullText Fong P: Mouse models for human epithelial disease: novel insights and new horizons. Exp Physiol 2009, 94:169-170. PubMedAbstract | PublisherFullText Chang JC, Wooten EC, Tsimelzon A, Hilsenbeck SG, Gutierrez MC, Tham YL, Kalidas M, Elledge R, Mohsin S, Osborne CK, Chamness GC, Allred DC, Lewis MT, Wong H, O'Connell P: Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients. J Clin Oncol 2005, 23:1169-1177. PubMedAbstract | PublisherFullText Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC: Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008, 100:672-679. PubMedAbstract | PublisherFullText Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003, 112:1776-1784. PubMedAbstract | PublisherFullText | PubMedCentralFullText Continued here: Epithelial-mesenchymal transition, cancer stem cells and ... … Continue reading →

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Human Mesenchymal Stem Cells & Media – Lonza

Posted: Published on September 27th, 2014

Bone marrow contains a population of rare progenitor cells known as Mesenchymal Stem Cells (MSC) capable of replication as undifferentiated cells or differentiating into bone, cartilage, fat, muscle, tendon and marrow stroma. Due to the nature of mesenchymal stem cells (MSCs), they can play a vital role in several different types of research applications including cell differentiation and gene regulation, gene therapy and transplantation, and cell-based screening assays in drug discovery. Cell Differentiation and Gene RegulationThe commitment of MSCs to a particular lineage is regulated by various signals from the cells' environment. Thus, there are many entry points into the process which can be exploited by researchers to help elucidate gene regulation and/or function. siRNA can be used to decrease the expression of a protein and allow one to better determine the function of the protein and pathways involved. Using stem cells allows one to study protein function and regulation at different stages in differentiation. Gene Therapy and Transplantation Mesenchymal stem cells have the potential to treat a wide range of diseases. Compared to other types of stem cells, MSCs have the ability to take up and keep introduced genes, a phenomenon that could be exploited for the delivery of … Continue reading →

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Nebraska coach's son to get second transplant

Posted: Published on September 27th, 2014

Nebraska assistant Chris Harriman and his son, Avery, before a game. (Scott Bruhn, Nebraska Athletics) Every six hours every single day. That's how often little Avery Harriman has been taking showers lately. Every six hours. Every long and hard day. "Because if he were to sweat, the chemo would burn his skin," explained Avery's father, Nebraska assistant Chris Harriman. "That's how toxic it was. So he had to shower every six hours. But the kid got through it. He rolled through it." Today is #AveryStrong Day throughout the state of Nebraska. From 6 a.m. to 9 p.m., folks will gather at a local Scooter's Coffee to increase awareness for the 7-year-old patient who just endured another aggressive round of chemotherapy while battling leukemia for a third time, and to raise money for Make-A-Wish Nebraska and Camp CoHoLo. Scooter's Coffee has agreed to donate $1 from every transaction made at each area location. More than $10,000 in donations is expected to be generated. Meanwhile, Avery will be having a stem cell transplant at the Nebraska Medical Center, this after enduring a bone marrow transplant last year. Perhaps you remember: I've told his story before. But it's worth revisiting today because a … Continue reading →

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How Face Aerobics Regimens Can Improve Your Beauty With Minimal Effort – Video

Posted: Published on September 27th, 2014

How Face Aerobics Regimens Can Improve Your Beauty With Minimal Effort Women and guys should really stop turning to aesthetic surgery and processes as a first option to shrink jowls, expel wrinkles, and trim eye bags, and give t... By: Lisa Kattenhorn … Continue reading →

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Dr Jake Lim – Plastic & Cosmetic Surgeon – Cosmetic …

Posted: Published on September 27th, 2014

CLICK ON PROCEDURE TO LEARN MORE face breast body non-surgical Welcome to the plastic surgery, face lift & cosmetic plastic surgery procedure website of Dr Jake Lim in Sydney Australia. Dr Lims practice offers a large range of services that combines 21 years of surgical experience along with compassionate care in a warm and inviting environment. Dr Lim combines his experienced surgical skills and unique artistic vision to create beautiful, natural looking plastic surgery results for his Australia-wide and international clients. The field of cosmetic plastic surgery is complex and can be confusing if you dont have access to the right information. Dr Lim takes his time to explain in detail to each and every patient all aspects of the cosmetic plastic surgery procedure they are considering. Unable to obtain information from facebook... Listen to my ads covering various cosmetic surgery topics such as breast enhancement, tummy tuck, rhinoplasty (nose surgery) and post-pregnancy surgery. Thanks for listening! Visit link: Dr Jake Lim - Plastic & Cosmetic Surgeon - Cosmetic ... … Continue reading →

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California Surgical Institute – Breast Augmentation …

Posted: Published on September 27th, 2014

Breast Augmentation / Breast Implants Breast augmentation utilizes FDA approved silicone or salinebreast implants to enhance the shape and size of the breasts. Breast Augmentation is performed by placing breast implants under the muscle through a small incision made through the areola, through the armpit, under the fold of the breast or through the belly button. Utilizing the most advanced techniques, our breast augmentation surgeons are experts in the field, creating natural looking and feeling breasts. Breast augmentation is sometimes performed alongside abreast lift to achieve the best results. Abdominoplasty ortummy tuck is the most common procedure by plastic surgeons forflattening the stomach. The tummy tuck helps women who have stretched muscles and skin after pregnancy, or for women who have lost a great deal of weight. The tummy tuck removes excess skin from the middle and lower abdomen and tightens the abdominal wall. The tummy tuck can also be easily performed within 2 - 5 hours. A simpler variant, the mini tummy tuck, can be performed for certain situations. Get your tummy tuck from us in order to restore the tightness of your abdominal wall. ABrazilian Butt Lift, also know as aBrazilian Butt Fill, is the most common procedure … Continue reading →

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