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A multi-function protein is key to stopping genomic parasites from ‘jumping’

Posted: Published on September 23rd, 2014

PUBLIC RELEASE DATE: 23-Sep-2014 Contact: Peter Iglinski peter.iglinski@rochester.edu 585-273-4726 University of Rochester @UofR Most organisms, including humans, have parasitic DNA fragments called "jumping genes" that insert themselves into DNA molecules, disrupting genetic instructions in the process. And that phenomenon can result in age-related diseases such as cancer. But researchers at the University of Rochester now report that the "jumping genes" in mice become active as the mice age when a multi-function protein stops keeping them in check in order to take on another role. In a study published today in Nature Communications, Professor of Biology Vera Gorbunova and Assistant Professor of Biology Andrei Seluanov explain that a protein called Sirt6 is needed to keep the jumping genestechnically known as retrotransposonsinactive. That's an entirely different function from the ones scientists had long associated with Sirt6, such as the repairing of broken DNA molecules and regulating metabolism. "About half of the human genome is made up of retrotransposons," said Gorbunova. "By better understanding why these genomic parasites become active, we hope to better understand and perhaps delay the aging process in humans." For the most part, retrotransposons remain silent and inactive in organisms' genomes. But once they do become active, these DNA … Continue reading →

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William Gotsis, MD, Appointed Director of Clinical Cardiology at Mount Sinai Heart at Mount Sinai St. Luke’s

Posted: Published on September 23rd, 2014

Contact Information Available for logged-in reporters only Newswise Interventional Cardiologist William Gotsis, MD, has been appointed Director of Clinical Cardiology of Mount Sinai Heart at Mount Sinai St. Lukes. Dr. Gotsis joins Mount Sinai St. Lukes from Crystal Run Healthcare. His appointment builds upon the newly established Mount Sinai-Crystal Run Alliance for Healthcare Transformation, a new partnership seeking opportunities to benefit the communities and patients of Mount Sinai and Crystal Run Healthcare. We are excited to welcome Dr. Gotsis to Mount Sinai St. Lukes, says Arthur Gianelli, President of Mount Sinai St. Lukes. In his new role, Dr. Gotsis will help expand and optimize our hospitals clinical cardiology services, including those of the Cardiac Catheterization Laboratory. I look forward to joining the talented heart team at Mount Sinai St. Lukes and nurturing the new partnership between Mount Sinai and Crystal Run for cardiovascular services, says Dr. Gotsis. Working together we will help establish Mount Sinai St. Lukes as a premier center of excellence for cardiac patient care. Dr. Gotsis, who specializes in interventional cardiology, joined Crystal Run in 1996. Most recently he has served as Director of Interventional Cardiology and The Interventional Fellowship Program Director at Westchester Medical Center, as … Continue reading →

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[Innovation Connecting Show, Toulouse] Biotech Becoming a Key Approach in Major Production and Processing Industries?

Posted: Published on September 23rd, 2014

From the oil industry to the pharmaceutical sector, biotechnology is now emerging as an indispensable element of Research & Development at the worlds leading companies. The term biotechnology started to become widespread in the 1980s when it first became feasible to transfer genetic information from one living system to another. Speaking at the Biotechnologies session of the Innovation Connecting Show (ICS) which took place on 16-18 September in the French city of Toulouse, Pierre Monsan, founder of the Toulouse White Biotechnology research centre, recalled how in the early 2000s it became increasingly possible for small laboratories to sequence the human genome. Todays synthetic biology differs in its methodology, but it has not deviated from the basic principle: acting on living organisms by manipulating their genetic make-up. Pierre Monsan told the ICS audience that the two major areas of biotechnology research today are the field of applied medicine, mainly with a view to treating cancerous cells, and also the energy sector. On the medical front, one example is how biotechnology specifically DNA sequencing is central to the work being done by researchers at Massachusetts-based clinical stage biopharmaceutical company Epizyme to analyse the different types of cancer. In general terms, we can … Continue reading →

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PhD Biology – Study at Maynooth University – Carla Surlis – Video

Posted: Published on September 23rd, 2014

PhD Biology - Study at Maynooth University - Carla Surlis If you're interested in studying for a PhD in Biology at Maynooth University please visit our website here: https://www.maynoothuniversity.ie/study-maynooth/... By: GoMaynooth … Continue reading →

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MCB Concentration Updates Receive Good Reviews

Posted: Published on September 23rd, 2014

Administrators behind the revamping of Molecular and Cellular Biology did not have to wait long to gauge the popularity of their new programs, courses, and requirement changes, said Alexander F. Schier, department chair of MCB. MCB 60: Cellular Biology and Molecular Medicine, our new gateway course, has enrolled more than 100 students, twice as many as expected, Schier said. After bringing on more teaching fellows to accommodate high enrollment, Schier, along with his MCB 60 teaching partners Vladimir Denic and Briana Burton, was eager to begin the new class, which implements curricular changes that relate lessons from the classroom to the science seen in news stories. The changes we made became possible because molecular and cellular biology has become highly relevant for understanding human physiology and disease, said Schier. It is now possible to directly connect most of the biological mechanisms we teach to human disease, ranging from cancer to Ebola. The teaching team has worked to leverage the increasing relevance of science at the molecular level to stories of outbreaks and popularly reported science. Highlighting these connections will help make the material more accessible to a broad range of students, Schier said. When you spend all your time in … Continue reading →

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Pitt-Bradford Alumni Association to honor Yaich, Foerstner at Alumni Weekend

Posted: Published on September 23rd, 2014

Dr. Lauren Yaich, associate professor of biology, and alumnus John Foerstner will be honored by the University of Pittsburgh at Bradfords Alumni Association during Alumni and Family Weekend Oct. 3-5. Yaich will accept the PBAA Teaching Excellence Award, and Foerstner will receive the Dennis Lowery PBAA Distinguished Volunteer Award. Both will be recognized at the PBAA Awards Brunch and Athletic Hall of Fame Induction at 10:30 a.m. Oct. 5 in the Mukaiyama University Room. The cost is $15 for adults; $6 for children ages 6-12; and free for children 5 and under. For registration, visit the website http://www.upb.alumni.org/afw or call 814-362-5091. Yaich has taught at Pitt-Bradford since 1998. In addition to her work in the classroom, where she teaches cell and molecular biology; genetics; developmental biology; cell biology and special topics, she has served as chairwoman of the Division of Biological and Health Sciences and associate dean of academic affairs. Dr Yaich is an excellent professor and a great person to be viewed as a positive role model for students pursuing biological degrees and jobs, wrote Julia Pesce, who nominated her. She is known on campus for her work to encourage girls and young women to enter STEM (Science, Technology, … Continue reading →

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Letter: Biology and theology can mutually co-exist

Posted: Published on September 23rd, 2014

| Published 13 hours ago TO THE EDITOR: Many parents, knowing very well that their adult children will not have the opportunity to learn a biblical perspective of creation at public universities such as our 17 campuses in the UNC system, tend to send their kids to private schools where biology is taught with the book Biology: Gods Living Creation. Moreover, these church-going parents often home-school their children. Dr. William D. Snider of the University of North Carolina School of Medicine recently expressed his serious concern that the the contents of the book Biology: Gods Living Creation are responsible for misconceptions of basic biological concepts. One of our nations founding fathers, Thomas Jefferson, insisted that our national Constitution should separate church and state, and as a consequence, we, in our great nation, developed our curriculum both in public schools and colleges to use books like the textbook of biology by Ken Miller and Joe Levine. In recent years, there is a significant body of new knowledge that supports the view that creation as narrated in Genesis and biological evolution as advocated by Charles Darwin and neo-Darwinist scholars are not mutually exclusive and, if properly interpreted and explained, students need not … Continue reading →

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The mechanics of tissue growth

Posted: Published on September 23rd, 2014

PUBLIC RELEASE DATE: 23-Sep-2014 Contact: Paul Kovach pkovach@pitt.edu 412-624-0265 University of Pittsburgh PITTSBURGH When the body forms new tissues during the healing process, cells must be able to communicate with each other. For years, scientists believed this communication happened primarily through chemical signaling. Now researchers at Carnegie Mellon University and the University of Pittsburgh have found that another dimension mechanical communication is equally if not more crucial. The findings, published in this week's issue of the Proceedings of the National Academy of Sciences, could lead to advancements in treatments for birth defects and therapies for cancer patients. "It's like 19th century scientists discovering that electricity and magnetism were the same force," said Lance Davidson, associate professor of Bioengineering at the University of Pittsburgh, who co-led the study. "The key here is using mechanical engineering tools and frameworks to reverse-engineer how these biological systems work, thereby giving us a better chance to develop methods that affect this cellular communication process and potentially treat various diseases related to tissue growth." "We answered this very important biological question by building a new tool that enabled us to see these mechanical processes at the cellular level," said Philip LeDuc, professor of Mechanical Engineering at … Continue reading →

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Sandia Researchers Find Clues to Superbug Evolution

Posted: Published on September 23rd, 2014

Contact Information Available for logged-in reporters only Newswise LIVERMORE, Calif. Imagine going to the hospital with one disease and coming home with something much worse, or not coming home at all. With the emergence and spread of antibiotic-resistance pathogens, healthcare-associated infections have become a serious threat. On any given day about one in 25 hospital patients has at least one such infection and as many as one in nine die as a result, according to the Centers for Disease Control and Prevention. Consider Klebsiella pneumoniae, not typically a ferocious pathogen, but now armed with resistance to virtually all antibiotics in current clinical use. It is the most common species of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. As carbapenems are considered the antibiotic of last resort, CREs are a triple threat for their resistance to nearly all antibiotics, high mortality rates and ability to spread their resistance to other bacteria. But there is hope. A team of Sandia National Laboratories microbiologists for the first time recently sequenced the entire genome of a Klebsiella pneumoniae strain, encoding New Delhi Metallo-beta-lactamase (NDM-1). They presented their findings in a paper published in PLOS One, Resistance Determinants and Mobile Genetic Elements of an NDM-1 … Continue reading →

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Primals 3D Human Functional Anatomy – Bring functional anatomy to life… – Video

Posted: Published on September 23rd, 2014

Primals 3D Human Functional Anatomy - Bring functional anatomy to life... Access your 24 hour free trial today http://bit.ly/Youtube_FreeTrial Primal's 3D Human Functional Anatomy is a hugely popular and versatile digital resource,... By: Primal Pictures - 3D Human Anatomy … Continue reading →

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