By Tom Abate Jennifer Cochran and Amato Giaccia are members of a team of researchers who have developed an experimental therapy to treat metastatic cancer. A team of Stanford researchers has developed a protein therapy that disrupts the process that causes cancer cells to break away from original tumor sites, travel through the bloodstream and start aggressive new growths elsewhere in the body. This process, known as metastasis, can cause cancer to spread with deadly effect. "The majority of patients who succumb to cancer fall prey to metastatic forms of the disease," said Jennifer Cochran, an associate professor of bioengineering who describes a new therapeutic approach in Nature Chemical Biology. Today doctors try to slow or stop metastasis with chemotherapy, but these treatments are unfortunately not very effective and have severe side effects. The Stanford team seeks to stop metastasis, without side effects, by preventing two proteins Axl and Gas6 from interacting to initiate the spread of cancer. Axl proteins stand like bristles on the surface of cancer cells, poised to receive biochemical signals from Gas6 proteins. When two Gas6 proteins link with two Axls, the signals that are generated enable cancer cells to leave the original tumor site, migrate … Continue reading
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