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Scientists 'reset' stem cells to earliest state

Posted: Published on September 13th, 2014

British and Japanese scientists have managed to "reset" human stem cells to their earliest state, opening up a new realm of research into the start of human development and potentially life-saving regenerative medicines. The work was described by one independent expert as "a major step forward". Scientists said they had successfully rebooted pluripotent stem cells so they were equivalent to those of a seven to ten-day old embryo, before it implants in the womb. By studying the reset cells, they said they hoped they would now be able to learn more about embryo development, and how it can go wrong and cause miscarriage and developmental disorders. "These cells may represent the real starting point for formation of tissues in the human embryo," said Austin Smith, director of the Britain's Cambridge Stem Cell Institute, who co-led the research published in the journal Cell. "We hope that in time they will allow us to unlock the fundamental biology of early development, which is impossible to study directly in people," he added. Human pluripotent stem cells, which have the potential to become any of the cells and tissues in the body, can already be made in a lab either from cells extracted from … Continue reading →

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Zebrafish Model of a Learning and Memory Disorder Shows Better Way to Target Treatment

Posted: Published on September 13th, 2014

Contact Information Available for logged-in reporters only Newswise PHILADELPHIA Using a zebrafish model of a human genetic disease called neurofibromatosis (NF1), a team from the Perelman School of Medicine at the University of Pennsylvania has found that the learning and memory components of the disorder are distinct features that will likely need different treatment approaches. They published their results this month in Cell Reports. NF1 is one of the most common inherited neurological disorders, affecting about one in 3,000 people. It is characterized by tumors, attention deficits, and learning problems. Most people with NF1 have symptoms before the age of 10. Therapies target Ras, a protein family that guides cell proliferation. The NF1 gene encodes neurofibromin, a very large protein with a small domain involved in Ras regulation. Unexpectedly, the Penn team showed that some of the behavioral defects in mutant fish are not related to abnormal Ras, but can be corrected by drugs that affect another signaling pathway controlled by the small molecule cAMP. They used the zebrafish model of NF1 to show that memory defects such as the recall of a learned task -- can be corrected by drugs that target Ras, while learning deficits are corrected by … Continue reading →

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GIOSTAR- STEM CELL THERAPY & DR ANAND SHRIVASTAVA – Video

Posted: Published on September 13th, 2014

GIOSTAR- STEM CELL THERAPY DR ANAND SHRIVASTAVA Global Institute of Stem cell Therapy and Research - GIOSTAR Introduction to Stem Cell Therapy, and Dr.Anand Shrivastava - Chairman Co-founder of GIOSTAR. By: Devang Parmar … Continue reading →

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44 – Nanomedicine by Toni Castro – Video

Posted: Published on September 13th, 2014

44 - Nanomedicine by Toni Castro 44 - Nanomedicine by Toni Castro. By: Bruce Rasmussen … Continue reading →

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Interview Dr.MS Basu, Explaining Retinitis Pigmentosa & its Treatments in Ayurveda – Video

Posted: Published on September 12th, 2014

Interview Dr.MS Basu, Explaining Retinitis Pigmentosa its Treatments in Ayurveda By: Mahendra Singh Basu … Continue reading →

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QLT Reports Positive Results From Phase 1b Trial With QLT091001

Posted: Published on September 12th, 2014

By RTT News, September 12, 2014, 07:19:00 AM EDT (RTTNews.com) - QLT Inc. ( QLTI ) Friday reported positive data from its Phase 1b retreatment trial with oral synthetic Cis-Retinoid or QLT091001 in patients with Leber Congenital Amaurosis or LCA or Retinitis Pigmentosa or RP. The results showed clinically significant improvements in visual fields with repeated dosing of QLT091001 in both LCA and RP patients with RPE65 or LRAT mutations. There was also a slight positive effect on visual acuity in both patient groups. The Phase 1b retreatment trial was a multicenter, open-label extension study in which LCA or RP patients with RPE65 or LRAT mutations who had been treated with a single course of QLT091001 in the company's previously completed Phase 1b study, received up to three 7-day courses of QLT091001 to evaluate visual outcomes and safety following retreatment. For comments and feedback: contact editorial@rttnews.com http://www.rttnews.com Follow this link: QLT Reports Positive Results From Phase 1b Trial With QLT091001 … Continue reading →

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Beth's story – after a stem cell transplant – Video

Posted: Published on September 12th, 2014

Beth's story - after a stem cell transplant Renate talks about her experiences of recovering after a stem cell transplant. Have you or a loved one been affected by a bone marrow (or stem cell) transpla... By: Anthony Nolan … Continue reading →

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Japan carries out first iPS stem cell retina surgery

Posted: Published on September 12th, 2014

TOKYO: Japanese researchers on Friday (Sep 12) conducted the world's first surgery to implant "iPS" stem cells in a human body in a major boost to regenerative medicine, two institutions involved said. A female patient in her 70s with age-related macular degeneration (AMD), a common medical condition that can lead to blindness in older people, had a sheet of retina cells that had been created from iPS cells implanted. "It is the first time in the world that iPS cells have been transplanted into a human body," a spokeswoman for Riken, one of the research institutions, told AFP. The research team used induced Pluripotent Stem (iPS) cells - which have the potential to develop into any cell in the body - that had originally come from the skin of the patient. Until the discovery of iPS several years ago, the only way to obtain stem cells was to harvest them from human embryos. "We feel very much relieved," ophthalmologist Masayo Takahashi, the leader of the project at Riken, told a news conference after the surgery in Kobe. "We want to take it as a big step forward. But we must go on and on from here." In a statement, the … Continue reading →

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Toronto Cosmetic Surgery Clinic Now Offering Volift

Posted: Published on September 12th, 2014

Toronto, Ontario (PRWEB) September 12, 2014 Edelstein Cosmetic, a cosmetic surgery clinic in Toronto, is one of the first clinics in Canada to offer the newest injectable filler product in the Juvderm line: Volift. Theres no doubt that patients want something to effectively resolve their aesthetic concerns that is the least invasive possible and can achieve lasting results, states Dr. Jerome Edelstein, Head of the Division of Plastic Surgery at the Humber River Hospital and primary plastic surgeon at Edelstein Cosmetic. Injectable fillers, like Volift, can be a great way to rejuvenate facial contours without surgery, and results have been shown to last longer than a year. Volift is a hyaluronic acid based filler designed to address deep skin depressions that have been caused by aging. These include nasolabial folds (creases extending from the outer corners of the nostrils to the mouth), thinning lips and marionette lines. Clinical studies have shown results can last up to 15 months for the treatment of nasolabial folds, which is a few months longer than the industry norm. The product is enhanced with lidocaine to reduce discomfort associated with the injection process. Until September 30, 2014, Edelstein Cosmetic is giving patients a free laser … Continue reading →

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Next-Generation Stem Cells Transplanted in Human for the First Time

Posted: Published on September 12th, 2014

Surgeons implanted retinal tissue created after reverting the patient's own cells to a "pluripotent" state Researchers were able to grow sheets of retinal tissue from induced pluripotent stem cells, and have now implanted them for the first time in a patient. Credit: RIKEN/Foundation for Biomedical Research and Innovation A Japanese woman in her 70s is the world's first recipient of cells derived from induced pluripotent stem cells, a technology that has created great expectations since it could offer the same advantages as embryo-derived cells but without some of the controversial aspects and safety concerns. In a two-hour procedure starting at 14:20 local time today, a team of three eye specialists lead by Yasuo Kurimoto of the Kobe City Medical Center General Hospital, transplanted a 1.3 by 3.0 millimeter sheet of retinal pigment epithelium cells into an eye of the Hyogo prefecture resident, who suffers from age-related macular degeneration. The procedure took place at the Institute of Biomedical Research and Innovation Hospital, next to the RIKEN Center for Developmental Biology (CDB) where ophthalmologist Masayo Takahashi had developed and tested the epithelium sheets. She derived them from the patient's skin cells, after producing induced pluripotent stem (iPS) cells and then getting them … Continue reading →

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