A local high school hockey player who suffered a serious spinal cord injury on the ice is preparing to be transferred to a specialized rehabilitation center in Georgia next week.A.J. Quetta, a senior at Bishop Feehan High School in Attleboro, crashed head-first into the boards in a Jan Continue reading →

Introduction Vascular dementia (VD) is a heterogeneous brain disease, which is featured by cognitive impairment and cerebrovascular pathologies, with the incidence rate of at least 20% of dementia second to Alzheimers disease.1 In clinical, VD is manifested as cognitive, psychological and behavioral disorders, such as repeated questioning, irritability, depression, apathy, aggression, sleep disorders and other adverse behaviors.2 The common etiologies of VD include large artery atherosclerosis, small vessel disease, myogenic stroke and cardiovascular disorders.3 A variety of cellular signaling and regulatory mechanisms are implicated in AD, including apoptosis, oxidative stress and inflammation.4 Oxidative stress has been confirmed to be related to the pathogenesis and risk factors of VD, and antioxidant therapy might play a role in the management of VD.5 Moreover, the cognitive impairment is attributed to both vascular disease and neuroinflammation.6 At present, cholinesterase inhibitors are recognized as available therapeutic agents for VD, but these drugs may produce serious adverse reactions, such as gastrointestinal reactions, joint pain, dizziness and headache, while their ability to improve the patient remains to be determined.7 With the increasing proportion of the elderly, elucidating the molecular mechanism of VD and developing potent agents are urgent for improving the quality of life for patients and reducing the social burden. Idebenone is an analogue of coenzyme Q10 (CoQ10), which is a lipophilic electron carrier and endogenous antioxidant existing in all cell mitochondrial membranes.8 As a kind of benzoquinone that can produce reversible redox reaction, Idebenone affects the electron balance of mitochondria.9 In vitro research has revealed that Idebenone protects mitochondrial function against amyloid beta toxicity in primary cortical neurons.10 In view of its mechanism in mitochondria, Idebenone is extensively used to treat neurodegenerative diseases and diseases associated with mitochondrial etiology.11 A previous study has demonstrated that the cognitive status of patients with cerebrovascular disease and degenerative disorders can be notably improved after receiving Idebenone treatment.12 However, whether Idebenone is involved in alleviating VD by regulating oxidative stress and neuroinflammation remains unclear Continue reading →

VANCOUVER, British Columbia, Feb. 13, 2021 /PRNewswire-PRWeb/ -- ABI Wellness, creators of the integrated patient care, tracking, and reporting approach designed under CEO Mark Watson, today announced that its Brain Enhance and Recovery System (BEARS) is now available through Sea to Sky Sports Physio in Squamish, BC, Canada Continue reading →

Third degree burns, or full-thickness burns, are a type of burn that destroys the skin and may damage the underlying tissue. They are more severe than first or second degree burns and always require skin grafts. Continue reading →

Dementia is an umbrella term encompassing many differing conditions that affect the structure and function of the brain. These conditions can lead to problems with memory, orientation, word-finding and problem-solving. Vascular dementia is the second most common form of dementia diagnosed in those over the age of 65, with 150,000 people in the UK living with this condition (NHS) Continue reading →

Feb 11, 2021 3:30 PM A seizure is a medical condition that causes abnormal activity and/or body movements after a sudden and uncontrolled disturbance in your brain. Continue reading →

Introduction Neonatal hypoxia-ischemia (HI) brain injury is associated with mortality or severe neurological disabilities.1 Accordingly, understanding of the pathologic and survival mechanisms of HI injury on brain functions represents a critical area of investigation for the development of neuroprotective treatments. Hydrogen sulfide (H2S) has been reported to be involved in modulating physiological and pathological processes within the central nervous systems.2,3 Normally, in mammalian cells, H2S originates from the metabolism of L-Cysteine through catalysis involving three enzymes, cystathionine--synthase (CBS), cystathionine--lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). These H2S-producing enzymes are highly expressed in various types of tissue and cells, including the brain.4 An exogenous administration of H2S has been shown to exert a neuroprotective effect through its capacity to affect anti-apoptotic, anti-inflammatory and anti-oxidative functions.5,6 Recently, we reported that L-Cysteine was able to suppress HI-induced microglial activation and neuroinflammation by releasing H2S.7,8 Although these reports indicate neuroprotective effects of H2S, the underlying mechanisms of this neuroprotection against brain damage resulting from HI have not been fully elucidated Continue reading →

Introduction Intracerebral hemorrhage (ICH) is a severe form of stroke, accounting for 10% of the stroke patients.1 ICH is a common cerebrovascular disorder with high mortality, which has become a heavy burden for families and countries.2 ICH refers to the extravasation of blood caused by the rupture of blood vessels within the brain parenchyma, resulting in neuronal death.3 In the last years, the morbidity of ICH is increasing, however, it is still devoid of effective treatment.4 Evidences during the past decades prove that the pathological process of ICH includes the primary brain damage resulting from mass effect owing to hematoma formation, and the secondary brain injury triggered by the extension of hematoma into the ventricles.5 Hence, a depth understanding of the mechanism underlying ICH-induced secondary brain damage has considerable significance that will help to develop efficient therapeutic strategies for ICH. Hemin is a breakdown product of hemoglobin and is the main cause of neuronal death during ICH.6 Following ICH, hemolysis of erythrocytes leads to hematoma resolution and the release of hemoglobin into the brain tissues.7 Subsequently, hemin liberated from hemoglobin may intercalate into cell membranes directly or enter brain cells via the heme carrier protein 1/proton-coupled folate transporter.8 When hemin internalizes to brain cells, hemin can trigger DNA fragmentation, oxidative stress and inflammatory response, resulting in cell death.9 Besides, hemin is catabolized by heme oxygenases into biliverdin, CO, and iron, which in turn causes lipid peroxidation.10 Increasing evidence suggests that hemin-induced apoptosis and inflammation have emerged as vital contributors to ICH-induced brain damage.11 Nevertheless, the mechanism of hemin-induced apoptosis and inflammation remains elusive. Understanding the mechanism underlying hemin-induced apoptosis and inflammation, therefore, is of significance for ICH therapy Continue reading →

Westbound traffic stopped at Downtown Tunnel due to crash involving tractor-trailer Bipartisan teen driving safety bill passes Virginia General Assembly unanimously US Sen. Warner leaves checkup of Hampton VA hospital with upbeat report on COVID-19 vaccinations, wait times Virginias COVID-19 vaccine registration site goes online, experiences some issues Black History Month: Local NBA referee scores big with philanthropy and fine dining Congressional dysfunction has compromised Navy funding, training, local congressman says Chesapeake Regional healthcare partnering with 20 African American churches to provide COVID-19 vaccines From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League Dominion Energy gives $50,000 boost to mental health clinic for military families, children WAVY News 10 at 6:00 pm US lawmakers weigh options to guarantee election security in the future WAVY's Andy Fox walks you through Virginia's new statewide COVID-19 vaccine registration system North Carolina tornado news conference Latest Bipartisan teen driving safety bill passes Virginia General Assembly unanimously News / 3 hours ago US Sen. Warner leaves checkup of Hampton VA hospital with upbeat report on COVID-19 vaccinations, wait times News / 3 hours ago Virginias COVID-19 vaccine registration site goes online, experiences some issues News / 3 hours ago Black History Month: Local NBA referee scores big with philanthropy and fine dining News / 3 hours ago Congressional dysfunction has compromised Navy funding, training, local congressman says News / 3 hours ago Chesapeake Regional healthcare partnering with 20 African American churches to provide COVID-19 vaccines News / 3 hours ago From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League News / 3 hours ago Dominion Energy gives $50,000 boost to mental health clinic for military families, children News / 3 hours ago WAVY News 10 at 6:00 pm News / 3 hours ago US lawmakers weigh options to guarantee election security in the future News / 5 hours ago WAVY's Andy Fox walks you through Virginia's new statewide COVID-19 vaccine registration system News / 5 hours ago North Carolina tornado news conference News / 8 hours ago Local News From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League News / 3 hours ago Dominion Energy gives $50,000 boost to mental health clinic for military families, children News / 3 hours ago WAVY News 10 at 6:00 pm News / 3 hours ago Black History Month: Local NBA referee scores big with philanthropy and fine dining News / 3 hours ago Sen. Continue reading →