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Kite Pharma announces positive results in patients with aggressive non-Hodgkin’s lymphoma

Posted: Published on August 26th, 2014

PUBLIC RELEASE DATE: 25-Aug-2014 Contact: Justin Jackson jjackson@burnsmc.com 212-213-0006 x327 Burns McClellan Santa Monica, CA August 25, 2014 Kite Pharma, Inc., (NASDAQ: KITE), a clinical-stage biopharmaceutical company focused on developing engineered autologous T cell therapy (eACT) products for the treatment of cancer, today announced the publication of clinical results in a cohort of patients demonstrating the potential to treat aggressive non-Hodgkin's lymphoma with an anti-CD19 chimeric antigen receptor (CAR) T cell therapy. Kite's most advanced product candidate, KTE-C19, is an anti-CD19 CAR T cell therapy that involves genetically modifying a patient's T cells to express a CAR that is designed to target CD19, a protein expressed on the cell surface of B cell lymphomas and leukemias. The findings from an ongoing Phase 1-2a clinical trial funded by Kite and conducted by the Surgery Branch of the National Cancer Institute (NCI) demonstrated that in 12 out of 13 evaluable patients with advanced B-cell malignancies, administration of anti-CD19 CAR T cells resulted in complete remission in eight patients and partial remission in four patients, representing an overall objective response rate of 92%. Of seven evaluable patients with chemotherapy-refractory DLBCL, four achieved complete remission, three of which are ongoing with durations ranging from … Continue reading

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Site Last Updated 10:57 pm, Monday

Posted: Published on August 26th, 2014

JOHOR BAHARU: The National Biotechnology Talent Development Centre will be set up in Johor to address competency gaps in human capital requirement for the biotechnology industry. Established through collaboration between the Malaysian Biotechnology Corporations (BiotechCorp) Industry Centre of Excellence for Biotechnology, Johor Biotechnology and Biodiversity Corporation (J-Biotech), and Universiti Malaysia Pahang, the centre is set to begin operation early next year. Johor Menteri Besar Datuk Seri Mohamed Khaled Nordin said the centre would help produce competent human capital for the biotechnology industry and woo foreign companies to invest in the sector in the state. Companies could provide opportunities to students to undergo industrial internship to prepare them for the biotechnology industry, he told a news conference after opening the Johor Bio Conference & Exhibition 2014 here yesterday. J-Biotechs chief executive officer Wan Amir Jeffery Wan Abdul Majid said the centre would be located at the J-Biotech premise at the outset. We are not going to build big buildings or infrastructure. We will coordinate with the industry and use their equipment or premise to provide training to students, he said. BiotechCorp chief executive officer Datuk Dr Mohd Nazlee Kamal said the training modules and trainers would be provided through public-private partnership … Continue reading

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ETEP BIOLOGY TEACHER – Video

Posted: Published on August 26th, 2014

ETEP BIOLOGY TEACHER Extended Teacher Education Program at University of Southern Maine advising. University of Southern Maine Biology department advising. Careers in Teaching and Teacher Education. By: University of Southern Maine Biology Advising … Continue reading

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RNA sequence could help doctors to tailor unique prostate cancer treatment programs

Posted: Published on August 26th, 2014

PUBLIC RELEASE DATE: 25-Aug-2014 Contact: Shane Canning shane.canning@biomedcentral.com 44-203-192-2429 BioMed Central Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal Genome Biology. Because a tumor's RNA shows the real time changes a treatment is causing, the authors think this could be a useful tool to aid diagnosis and predict which treatment will most benefit individual cancer patients. Colin Collins and Alexander Wyatt, and other researchers from the Vancouver Prostate Centre at the Vancouver Coastal Health Research Institute, matched 25 patients' treatment outcomes with the RNA sequence of their prostate cancer tumors. They suggest that similarities between the RNA of some of the patients' tumors could open up new avenues of treatment. Prostate cancer is the fourth most common cancer worldwide, but can be effectively managed. Doctors normally recommend a combination of therapies, because patients' reaction to treatment varies considerably. The side-effects of these treatments can be significant, so current research is focused around precision medicine classifying patients on their tumor's molecular changes, and only giving them the treatments that are expected to be most effective. To investigate variations between the highest risk cases … Continue reading

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Penn State Launches New Online Graduate Certificate in Applied Bioinformatics

Posted: Published on August 26th, 2014

University Park, Pennsylvania (PRWEB) August 26, 2014 The breakthrough of sequencing the human genome created a need for professionals with backgrounds in life and computer sciences to analyze vast amounts of biological data for developing gene-based drugs and treatments. In response, Penn State World Campus is offering a new graduate certificate in applied bioinformatics that will train a new generation of biomedical researchers in computational thinking and procedures. These skills will allow them to apply algorithmic processes, tools and techniques to their data for a deeper understanding of biological processes. Faculty from the Penn State Eberly College of Science will teach the 11-credit certificate program. This field is really poised to grow and impact society as a whole, said Istvan Albert, associate professor of bioinformatics, biochemistry and molecular biology and the lead faculty member for the certificate program. I think were only at the beginning of understanding how cellular activity works, and the best is yet to come. What life scientists currently need the most is the availability of training that imparts the know-how and practical knowledge that can be put to immediate use in biomedical labs that rely on sequencing technologies. Applications are now being accepted for enrollment in … Continue reading

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ABRF Assesses NGS Platforms, Library Prep, Bioinformatics in Effort to Create RNA-seq Standards

Posted: Published on August 26th, 2014

Michael Stitzel joked that his research has led him to climb up the evolutionary tree. As an undergraduate he worked with yeast, and over the years, he has worked his way up to studying Drosophila, C. elegans, and, now, people. Stitzel shifted from the more basic roots of the tree to the biomedical limbs as a matter of motivation. He said that as a graduate student, though he worked on an important and interesting question, when experiments didn't go well, it was hard for him to get motivated. And so, he found himself drawn to questions with more direct relevance to medicine. He turned to studying type 2 diabetes. Using a genome-wide association study approach, he identified a number of regions in the genome linked to the disease, but many of them were, as he put it, "in the middle of nowhere." This led him to thinking about epigenetics, and then to later uncover what he and his colleagues dubbed 'stretch enhancers,' longer-than-average enhancers that appear to be driving physiological functions. Read more here: ABRF Assesses NGS Platforms, Library Prep, Bioinformatics in Effort to Create RNA-seq Standards … Continue reading

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Stanford bioengineers close to brewing painkillers without opium from poppies

Posted: Published on August 26th, 2014

By Tom Abate Stanford bioengineer Christina Smolke has been on a decade-long quest to genetically alter yeast to "brew" opioid medicines in stainless steel vats, eliminating the need to raise poppies. For centuries poppy plants have been grown to provide opium, the compound from which morphine and other important medicines such as oxycodone are derived. Now bioengineers at Stanford have hacked the DNA of yeast and reprogrammed these simple cells to make opioid-based medicines via a sophisticated extension of the basic brewing process that makes beer. Led by bioengineering Associate Professor Christina Smolke, the Stanford team has already spent a decade genetically engineering yeast cells to reproduce the biochemistry of poppies, with the ultimate goal of producing opium-based medicines, from start to finish, in fermentation vats. "We are now very close to replicating the entire opioid production process in a way that eliminates the need to grow poppies, allowing us to reliably manufacture essential medicines while mitigating the potential for diversion to illegal use," said Smolke, who outlines her work in the Aug. 24 edition of Nature Chemical Biology. In the new report, Smolke and her collaborators, Kate Thodey, a postdoctoral scholar in bioengineering, and Stephanie Galanie, a doctoral student … Continue reading

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The Anatomy of an Effective Email – Video

Posted: Published on August 26th, 2014

The Anatomy of an Effective Email The Anatomy of an Effective Email. By: Tyler Garns … Continue reading

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Dynamos Bruin, Barnes, & Davis punish the Union for failing to play the whistle | Anatomy of a Goal – Video

Posted: Published on August 26th, 2014

Dynamos Bruin, Barnes, Davis punish the Union for failing to play the whistle | Anatomy of a Goal Just how much of a difference can a split-second make? This goal by the Houston Dynamo's Will Bruin perfectly exemplifies the consequences of switching off, and the benefits of being on. For... By: Major League Soccer … Continue reading

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Lecture 4 Anatomy of Android Application – Video

Posted: Published on August 26th, 2014

Lecture 4 Anatomy of Android Application By: Nikita Jain … Continue reading

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