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Laser surgery shows promise in halting seizures in epilepsy sufferers

Posted: Published on August 20th, 2014

PLEASANTON -- Justin Wan is not one to radiate unfettered optimism or make bold statements about his future. More than 10 years of battling epilepsy will do that to a person who never knows when the next seizure will strike. Wan can't drive, swim alone or live by himself. Crossing streets, taking a bath, riding a bike and new environments in general can pose unforeseen perils and pitfalls. This time last year, Wan, 20, often couldn't make it more than week without an epileptic attack and his senses were dulled by heavy doses of anti-seizure medications. But today, the only outward sign that he suffered from debilitating seizures is a small staple scar on the top of his head, hidden by a headful of thick black hair -- where surgeons in December inserted a tiny laser that zapped out a lesion in his brain. He hasn't had a seizure since. "It was on this side somewhere," the San Jose State junior said, feeling around with his fingers on his cranium's right side. "I was prepared for anything to backfire, but so far, everything is fine," Wan said, reaching for his family's wooden coffee table to give it a good knock … Continue reading

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Eisai Submits EU Marketing Authorisation Application for Fycompa (perampanel) as Adjunctive Therapy in People With …

Posted: Published on August 20th, 2014

Generalised tonic-clonic seizures are one of the most dangerous types of seizure.[2] The seizures start with a loss of consciousness and a sudden contraction of the muscles, which can cause the person to fall down (tonic phase). This is followed by violent convulsions (clonic phase) until the muscles finally relax.[3] The filing in this new indication is based on data from Study 332,[4] a double-blind, randomised, placebo-controlled, multicentre, parallel-group trial to evaluate the efficacy and safety of adjunctive perampanel for refractory PGTC seizures. 164 people (>12 years old) with PGTC seizures, despite treatment with one to three concomitant AEDs were randomised to receive perampanel or placebo in a 1:1 ratio. Results demonstrate that perampanel significantly reduces PGTC seizure frequency and improved responder rates (50% reduction in seizure frequency per 28 days in the maintenance period, relative to baseline), the study's two primary outcome measures, when compared to placebo. The most frequent adverse events (10% in the perampanel arm and greater than placebo) are dizziness, fatigue and headache, irritability and somnolence. The adverse event profile is similar to that for other perampanel studies.[4] "Tonic-clonic seizures are very serious and can have a profound effect on quality of life for people with … Continue reading

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Yoga for autism

Posted: Published on August 20th, 2014

If you go What: Yoga classes for children with autism and disabilities, organized by the nonprofit Pop.Earth When: Ages 5-10, 11 a.m.-noon Saturday; ages 11-17, 12:30 p.m.-1:30 p.m.. Where: The Yoga Pod, at the Twenty Ninth Street Mall, 1750 29th St., unit 2020, Boulder Cost: $15 drop-in; four classes for $40; or sliding scale to free. Info: popearth.org When you have a child with special needs, you never know what to expect when you open that car door, says Debbie Stone. She says she wanted to do everything she possibly could to help her son after he was diagnosed with autism, but the idea of shuffling him from one treatment to the next only some of which were covered by insurance was a nightmare. If only one single place offered all his treatments in one location, and if only the programs were low-cost or free, she thought. In 2012, she decided to do something about it. Stone created the New York-based nonprofit Pop.Earth, which offers low-cost holistic services for children with autism and other developmental disorders. View original post here: Yoga for autism … Continue reading

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I-DALI Mo Advocacy Campaign aspires for Stroke-Smart Region X

Posted: Published on August 20th, 2014

One in six people will suffer a stroke in their lifetime. With changing lifestyles, stroke has become more prevalent in developing countries like the Philippines and around the world, with stroke as the second leading cause of death. It is the leading cause of chronic disability in adults and the second leading cause of dementia. Lower national income has been associated with higher relative mortality and burden of disease from stroke. One third of stroke survivors are left permanently disabled for life and three quarters are vocationally impaired. Such is the burden of stroke. Dedication of the Brain Attack AGPAS Team with Dr. Ramon Moreno (photo courtesy of Dr. Art Surdilla) Last August 8, 2014, the Northern Mindanao Medical Center (NMMC) launched a three-pronged counter attack on stroke with the inauguration of its 11-bed Neuro Intensive-Acute Stroke Unit and 10-bed Stroke Ward, dedication of the AGPAS (Active Group of People Against Stroke) Team , and the launching of the I-DALI Mo early stroke recognition advocacy campaign. I-DALI Mo aims to ramp up public awareness about stroke and make Northern Mindanao a stroke-smart region, with the capability to effectively prevent, treat and rehabilitate stroke patients, said Dr. Arturo F Surdilla, MD, … Continue reading

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Billy Connolly's wife noticed his hand shaking for a decade before Parkinson's diagnosis

Posted: Published on August 20th, 2014

AP Photo Billy Connolly and Pamela Stephenson arrive at the Moet British Independent Film Awards 2012. Comedy star Billy Connolly may have had Parkinson's disease for around 10 years before it was diagnosed, his wife says. Pamela Stephenson, 64, said that she had noticed her husband's hand shaking for many years, but assumed that he had just spent too long playing the banjo. Connolly, 71, has told how he was diagnosed with prostate cancer and Parkinson's disease on the same day. Now Stephenson has told BBC Radio 5 live in the UK that the star is "doing incredibly well". "He's been ill and it was a huge shock for him. For someone who's been healthy his whole life, to suddenly hear that he had two major problems in a week. He had cancer, he's got Parkinson's...." "But thank God his Parkinson's is so mild he will never really have the kind of symptoms that many people associate with Parkinson's, as far as we know." "He's probably had it for 10 years, so it's very, very slowly progressing... There are different strains of Parkinson's that I'm learning about." "I've actually noticed his hand shaking for many, many years... I used to … Continue reading

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New fury in York IVF row

Posted: Published on August 19th, 2014

New fury in York IVF row Updated 6:19pm Tuesday 19th August 2014 in News By Kate Liptrot A YORK health boss is facing calls to resign after it emerged he did not vote in a crucial decision over IVF because he is campaigning as a Labour election candidate. Dr Mark Hayes has come under pressure to reconsider his work on the Vale of York Clinical Commissioning Group after it emerged the chief clinical officer could not cast a vote in favour of providing IVF treatment due to his political work. The Labour candidate for Selby and Ainsty has previously said he wishes to end a situation in which his CCG is the only one in the whole of the UK not to offer IVF. Despite announcing it would provide a single cycle of the fertility treatment IVF, the Vale of York Clinical Commissioning Group (CCG) backtracked on the decision earlier this month on a narrow 5-4 vote, deciding to delay plans because it cannot afford the service. The matter has been raised by Skipton and Ripon Julian Smith, who said the best outcome would be for Dr Hayes to step down from the post until the 2015 General Election is … Continue reading

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Announcing Speakers at BioConference Live Genetics and Genomics 2014

Posted: Published on August 19th, 2014

Yorba Linda, CA (PRWEB) August 19, 2014 BioConference Live Genetics and Genomics recently announced new speakers for their virtual conference scheduled for August 20-21, 2014. The Annual Genetics and Genomics Virtual Conference welcomes Dr. Gordon Mills and Dr. Robert Nussbaum as the keynote speakers during the event. The one-of-a-kind global web-based conference will be conducted through live video webcasts and real-time networking. Dr. Mills will be presenting Delivering on the promise of personalized medicine. The realization of the promise of personalized molecular medicine requires efficient development and implementation of novel targeted therapeutics linked to molecular markers able to identify patients most likely to benefit. An efficient integration of DNA, RNA and protein information content will be needed to identify patients likely to respond to particular therapies. A comprehensive analysis of patient tumors before, during and after treatment should become the standard of practice. Testing these precepts will require the development and implementation of novel trial designs. Keynote presenter Dr. Nussbaum will discuss the Clinical Validity and Utility in Whole Exome/Genome Sequencing. He is a member of the UCSF Institute for Human Genetics, where he is studying if and how genetic and genomic information can be used to improve health care … Continue reading

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Tissue specific optimized AAV Plasmids are now available to make research & therapy more targeted

Posted: Published on August 19th, 2014

(DGAP-Media / 19.08.2014 / 10:21) Tissue specific optimized AAV Plasmids are now available to make research & therapy more targeted Gene Therapy development progresses with tissue specific AAV Plasmids developed by Europe's leading commercial supplier of viral vectors, SIRION Biotech in Munich. Munich, 19 August 2014, viral vectors are a new class of biologics that help treat diseases caused by defective gene function / proteins ("gene therapy"). More than 20 companies worldwide the majority of which originate in the United States are applying viral vectors to conduct clinical studies. A key hurdle when applying viral vectors is to limit the transduction (gene transfer) to the appropriate cells of a specific tissue without affecting their surrounding environment. But, how can an expression system differentiate between tissue or even cell type? SIRION Biotech, in cooperation with U of Munich (LMU) and U of Cologne, has developed a line of viral vectors with specific promotors that are only active in a specific set of targetetd cells to initiate the desired gene expression. Using this method, the gene of interest is only being expressed in the targeted tissue which is relevant for the desired therapy. This improves the effectiveness of the therapy and also … Continue reading

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Gene hope for heart patients

Posted: Published on August 19th, 2014

Ben Hirschler Tuesday, August 19, 2014 US biotech firm Celladon hopes that its Mydicar treatment can help Lee Adams and patients like him who have advanced heart failure and rely on devices to keep them alive until a donor heart becomes available. The treatment works by inserting a gene called SERCA2a - the lack of which makes hearts pump weakly - directly into heart cells via a catheter to repair them. The trial will evaluate how much of the gene is getting to the heart muscle and how well it is working. Adams is the first of 24 patients who will be given either the gene therapy or a placebo as part of a clinical study partially funded by the British Heart Foundation and sponsored by Imperial College London. "Advanced heart failure is a progressive condition that results in a poor quality of life and shortened life expectancy," said Nick Banner, the consultant cardiologist at Harefield Hospital who carried out the first infusion. "The best treatment currently available is a heart transplant but the shortage of donor organs means that many patients will die on the waiting list." Adams has been living for more than 2 years with a Left … Continue reading

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4-H – A hands on approach

Posted: Published on August 19th, 2014

ASHEBORO It is that time again. I have to get my mind thinking about school and the programs that we can offer our school systems. North Carolina Cooperative Extension and 4-H are grounded in education and that positions us to be helpful collaborators with our local school systems. Together we know what it takes to help youth achieve in the school setting. We offer Health Rocks for students in middle school. We implement chick embryology in the second grade. We offer water conservation lessons in third grade; bicycle safety education in fourth grade and environmental field days in fifth grade. Keeping kids in school and on task is not always easy. For youth who feel that school content is too hard or their test scores indicate they are not passing a course, the idea of dropping out can look like an ideal solution. Unfortunately, this is all to often the case. Dropping out of school is NOT an ideal solution. Youth who have been introduced to 4-H through a community club, school enrichment or special interest program know our programs are hands on. Using a hands on approach allows youth to become involved in an activity, determine what was useful … Continue reading

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