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'Biological basis' for depression in Parkinson's patients: expert

Posted: Published on August 15th, 2014

Robin Williams' widow stunned many of his fans Thursday when she announced that not only was her husband suffering from depression and anxiety at the time of his death, he also was in the early stages of Parkinson's Disease. Experts say Williams' case is not so unusual, as depression and Parkinson's are often linked. Dr. Michael Okun, the medical director of the National Parkinson Foundation's and a professor of neurology at the University of Florida, says depression among Parkinson's patients has been largely misunderstood until recently. "We have recently learned that depression in Parkinson's is actually quite common. It occurs in more than half of people with this disease and it is the largest unmet hurdle to treatment," Okun told CTV News Channel from Gainesville, Fla. Okun says several large studies in recent years have revealed that for many Parkinson's patients, depression is not just a reaction to their diagnosis -- although that does occur. The disease itself can increase the risk of depression, he says. "We now know there are biological changes in the brain, both from the degenerative process but also because of changes in chemicals such as dopamine, serotonin and norepinephrine. So we now know there is … Continue reading →

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Frustrating delay to Megans US surgery

Posted: Published on August 15th, 2014

Last updated at 14:43, Friday, 15 August 2014 A disabled Cockermouth girls dream of being able to ride a bicycle has suffered a major setback. BETTER DAY: Family and friends of Cockermouth youngster Megan White, centre, celebrate reaching the total of 40,000 in just one year to send Megan to America to have treatment Megan White, 14, was diagnosed at the age of two with cerebral palsy and spastic diplegia, which means she has poor co-ordination and trouble walking. She uses a walking stick, wheelchair or mobility scooter to get around. Her mum Kerrie Iredale, 37, of Bellbrigg Lonning, launched a campaign called Megans Dream in 2012 to raise 40,000 to get pioneering treatment in North America to help with her mobility. The target was reached late last year, thanks to several donations from the community. Megans ambition is that one day she will recover sufficiently to ride a bike like her sisters, her twin Leah and Kara. But Miss Iredale revealed this week that the St Louis Childrens Hospital, where Megan was due to get treatment, has written to say that the operation cannot go ahead at the moment because she has problems with one of her hips. After … Continue reading →

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Dr. Patrick Walsh, Director of the Marianjoy Psychology Department Appointed to the State of Illinois Brain and Spinal …

Posted: Published on August 15th, 2014

Wheaton, Illinois (PRWEB) August 15, 2014 Dr. Patrick Walsh, Director of the Marianjoy Psychology Department and Coordinator of the Brain Injury Program, has been appointed to the State of Illinois Brain and Spinal Cord Injury Advisory Council. This advisory council makes recommendations to the governor for developing and administering a comprehensive State Plan to provide services to individuals with brain or spinal cord injuries and to help prevent new injuries from occurring. Dr. Walsh joined Marianjoy Rehabilitation Hospital in 1998 upon completion of his doctoral degree in clinical psychology. He is a go Loyola University of Chicago and attained his doctorate degree from the Illinois School of Professional Psychology. He completed a post-doctoral residency in neuropsychology at Marianjoy. Dr. Walsh specializes in the areas of neuropsychology, brain injury, sports concussion, and rehabilitation psychology. He is a certified brain injury specialist through the American Brain Injury Association. Dr. Walsh is affiliated with the American Psychological Association, National Academy of Neuropsychology, and the Illinois Brain Injury Association. Marianjoy Rehabilitation Hospital is a 128-bed hospital located in Wheaton, Illinois providing inpatient, subacute, and outpatient rehabilitation. Founded in 1972 by the Wheaton Franciscan Sisters, Marianjoy maintains an extensive network of therapy locations and physician … Continue reading →

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Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons

Posted: Published on August 15th, 2014

Contact Information Available for logged-in reporters only Newswise A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports. The study, led by Guo-li Ming, M.D., Ph.D., and Hongjun Song, Ph.D., of the Johns Hopkins University School of Medicine and described online Aug. 17 in the journal Nature, used stem cells generated from people with and without mental illness to observe the effects of a rare and pernicious genetic variation on young brain cells. The results add to evidence that several major mental illnesses have common roots in faulty wiring during early brain development. This was the next best thing to going back in time to see what happened while a person was in the womb to later cause mental illness, says Ming. We found the most convincing evidence yet that the answer lies in the synapses that connect brain cells to one another. Previous evidence for the relationship came from autopsies and from studies suggesting that some genetic variants that affect synapses also increase the chance of mental illness. But those studies could not show a direct cause-and-effect relationship, Ming says. One difficulty in … Continue reading →

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New genetic test helps identify some mystery illnesses

Posted: Published on August 15th, 2014

William Smith's disease has grim milestones. At 2, the Gambrills triplet known as Mick couldn't walk or talk as well as his siblings. In kindergarten, he started losing language and motor skills. At 12, he needed a wheelchair and a feeding tube. Doctors at Johns Hopkins Hospital dedicated to treating his symptoms said he had an undiagnosed progressive neuromuscular disease. But a new test may provide something the family has long sought: a name. "The idea that there is something out there that can tell you [what's wrong] is huge," said Cathy Smith, Mick's mother. "There is a lot of pain that comes from not knowing what is wrong with your kid." The test, called whole exome sequencing, stems from the decades-long push to map all the genes in the human body and translate that knowledge into diagnostic tools and therapies. The test has been commercially available for less than three years ,and doctors say it still doesn't offer definitive information for most patients with genetic disorders. The largest published study, by scientists at Baylor College of Medicine in Houston, found diagnoses a quarter of the time, though the success rate appears to be rising. Data analysis takes three to … Continue reading →

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Petition launched against IVF lottery

Posted: Published on August 15th, 2014

Petition launched against IVF lottery Updated 10:55am Friday 15th August 2014 in News By Kate Liptrot A CAMPAIGN has been launched against a decision which has made York the only area in the UK not to fund fertility treatment. Despite announcing it would provide a single cycle of the fertility treatment IVF, the Vale of York Clinical Commissioning Group (CCG) backtracked on the decision earlier this month on a 5-4 vote, deciding to delay plans because it cannot afford the service. Now the support group York Fertility Network has launched a petition against the "postcode lottery" and is calling for York to bring its policy in line with the rest of the UK. The petition is due to be presented to the Vale of York CCG. Karen Boardman, a member of the York Fertility Network who is due to undergo IVF treatment, said: "The whole situation is a disgrace. To have given hope to so many couples across York and then snatched it away is simply wrong. "They have also said that it will cost 2 million to offer 110 people one cycle of IVF. This is absurd. The IVFYes campaign's research says on average it costs 3,434.70 per person … Continue reading →

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NewLink Genetics: Ready to Test Ebola Vaccine

Posted: Published on August 15th, 2014

An Iowa drug developer is preparing to test a possible Ebola vaccine in humans, as scientists race to develop ways to prevent or fight a virus that has killed more than 1,000 people in a West African outbreak. NewLink Genetics is planning an initial phase of testing involving up to 100 healthy volunteers and is talking with regulators about the study, said Brian Wiley, the company's vice president for business development. He declined to say whether the drug developer has submitted an application for the research to the Food and Drug Administration. Chief Financial Officer Gordon Link said Thursday the timing of the testing, which would involve up to 100 healthy volunteers, is uncertain. "We're getting a lot of assistance from a number of sources to accelerate this, so exactly how long it's going to take is a little uncertain because people are greasing the paths as much as they can," he said. There is no proven treatment or vaccine for Ebola, and the current outbreak, which also has sickened nearly 2,000 people, is the largest in history. The outbreak was first detected in March in Guinea and spread to Liberia, Sierra Leone and Nigeria. Other possible Ebola vaccines under … Continue reading →

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Spooky Chemistry – Amneedja: The Dick Croissant – Part 3 – Video

Posted: Published on August 15th, 2014

Spooky Chemistry - Amneedja: The Dick Croissant - Part 3 In this episode, Igm finds himself in quite a few "sticky" situations. In a bind, he looks to might and science for the solution. By: Igmdigm Gaming … Continue reading →

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Chemistry a problem for Arizona United SC

Posted: Published on August 15th, 2014

The excuse of being the new kid of USL Pro has gotten old. With five games left in its inaugural season, Arizona United SCs had five months to develop team chemistry and a winning game plan, but neither element has taken shape for much of the season, and the result has United sitting in last place. Including tonights game against the Oklahoma Energy FC, Arizona needs to win all five games to make the postseason, and it needs help from higher-seeded teams. Chemistry has been a problem for United all season, on and off the pitch. Players have confronted one another on multiple occasions during practice and games throughout the season. Devon Grousis, who played an integral role in the starting 11 early in April has been known to publish (via Twitter) his displeasure after losses or a lack of playing time. Since the posts, Grousis hasnt started since, and hes made just five appearances. Arizona is currently on a three-game losing streak with losses to Charleston, Sacramento and LA Galaxy II, and the cracks are starting to show. Arizona United coach Michael Dellorusso refused to talk to the media this week in preparation for the two matches in Oklahoma … Continue reading →

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Scripps Research Institute Chemists Uncover Powerful New Click Chemistry Reactivity

Posted: Published on August 15th, 2014

Contact Information Available for logged-in reporters only Newswise LA JOLLA, CAAugust 14, 2014Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute (TSRI) have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials and many other products. The new SuFExSulfur Fluoride Exchangereactions enable chemists to link molecules of their choice together using derivatives of a common commercial chemical considered essentially inert. The Sharpless team made this chemical reliably and predictably reactive. Astonishingly, acid-base constraints are rarely a concern, though they are central to nature's chemistry and an enormous hurdle for chemists. The stabile linkers are also non-polar and can enter cells, so have potential for crossing the blood-brain barrier. Consequently, SuFEx gives easy access to an entire, unexplored galaxy within the chemical universe. This is a new, emergent phenomenon, said Sharpless, the W.M. Keck Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI. Click chemistry, conceived in the mid-90s as a method for discovering new and improving existing chemical reactivity, became universally used in the chemical sciences after the 2002 discovery of copper-catalyzed azide-alkyne cycloaddition (CuAAC). Now SuFEx is the second perfect click reaction … Continue reading →

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