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Discovery of new form of dystrophin protein could lead to therapy for some DMD patients

Posted: Published on August 11th, 2014

PUBLIC RELEASE DATE: 10-Aug-2014 Contact: Gina Bericchia MediaRelations@nationwidechildrens.org 614-355-0495 Nationwide Children's Hospital Scientists have discovered a new form of dystrophin, a protein critical to normal muscle function, and identified the genetic mechanism responsible for its production. Studies of the new protein isoform, published online Aug. 10 in Nature Medicine and led by a team in The Research Institute at Nationwide Children's Hospital, suggest it may offer a novel therapeutic approach for some patients with Duchenne muscular dystrophy, a debilitating neuromuscular condition that usually leaves patients unable to walk on their own by age 12. Duchenne muscular dystrophy, or DMD, is caused by mutations in the gene that encodes dystrophin, which plays a role in stabilizing the membrane of muscle fibers. Without sufficient quantities of the protein, muscle fibers are particularly susceptible to injury during contraction. Over time, the muscle degenerates and muscle fibers are slowly replaced by fat and scar tissue. Many different types of mutations can lead to DMD, some of which block dystrophin production altogether and others that result in a protein that doesn't function normally. In 2009, a team led by Kevin Flanigan, MD, a principal investigator in the Center for Gene Therapy at Nationwide Children's, published … Continue reading →

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Stigma still associated with IVF: survey

Posted: Published on August 10th, 2014

PAA Almost half of Australian women believe that if they need IVF treatment, they've failed. Nearly one in two Australian women believes there's a common perception that you have "failed" if you seek IVF treatment, according to a survey. Despite an increasing number of babies being born from fertility procedures each year - currently about 12,000 - research by fertility clinic Bump found 85 per cent of women feel there's a social stigma associated with having in vitro fertilisation treatment. Nearly half of the 1007 women aged 25 to 44 surveyed say this is due to the perception that undergoing IVF treatment means you have "failed". Added to this, 32 per cent believe the stigma is because women can feel responsible and guilty even when it's their partner who has the fertility problem. Anne-Marie Pickard, 46, who had her son five years ago through IVF, said she can understand why many couples, and women in particular, would feel they've failed if they need IVF. "There's probably a little bit in my subconscious brain that feels that I failed because I didn't fall pregnant naturally," Ms Pickard said. "But consciously I know that's not the case." Ms Pickard says she has … Continue reading →

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Midsummer Nights’ Science: Genetics and Diabetes – Video

Posted: Published on August 10th, 2014

Midsummer Nights' Science: Genetics and Diabetes Copyright Broad Institute, 2013. All rights reserved. Designing new drugs would be easier if scientists understood the biology of the diseases they are trying to treat -- but for most common... By: broadinstitute … Continue reading →

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Genetics a ‘game-changer’ for wool

Posted: Published on August 10th, 2014

ANIMAL genetics could prove to be a game changer for the Australian wool industry. Through the adoption of genetics the modern day poultry, pig and dairy industries are no longer the same industries they were 40 years ago. But according to UWA professor David Lindsay, the Australian wool industry has been reluctant to grasp the benefits of animal genetics, and therefore has not changed in over 100 years. "Looking at the dairy (milk produced per cow) and the wool industry (wool produced per sheep), there is a huge disparity," he said. "Between 1940 and 1960 neither industries made any progress in their performance, but by 1960 there was the introduction of wide-scale measurement in the dairy industry and an introduction of AI as a management tool and suddenly the lines start to part. "The dairy industry has improved milk production per cow by 375 per cent. "But in contract the wool industry has not managed to significantly improve the productivity of wool produced per sheep." Mr Lindsay said there was no lack of potential for genetics to make game changing improvements in the wool industry "Just think about if we were able to double the amount of wool produced per … Continue reading →

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Pushpa Bhargava questions DBT guidelines on transgenic crops

Posted: Published on August 10th, 2014

Even as the Genetic Engineering Appraisal Committee (GEAC) decided to constitute a sub-committee to review the toxicology data generated by two applicants for genetically modified brinjal, biologist and Padma Bhushan award winner Dr. Pushpa M. Bhargava has questioned the guidelines of the Department of Biotechnology (DBT) on transgenic crops. Dr. Bhargava and others had asked for the raw data on toxicity studies on rats using transgenic brinjal which were carried out by Dr. Sesikeran, former Director of National Institute of Nutrition at Hyderabad. He found statistically quite significant differences between rats fed on Bt Brinjal and those fed on a normal meal in respect of several important parameters, said Dr. Bhargava. However, Dr. Sesikeran had said that as all the values (both of the control and of the experimental animals) fell within the normal range of variation, the differences were not significant, and that there was no need to repeat the experiment. Our point was that if on repetition the same differences are found again, they are bound to be significant, Dr. Bhargava pointed out. Further, he used only 20 animals (10 female and 10 male) in both experimental and the control groups which is the minimum number for such … Continue reading →

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DNA: History twisted; Freedom fighters labeled “terrorists” in WB – Video

Posted: Published on August 10th, 2014

DNA: History twisted; Freedom fighters labeled "terrorists" in WB A class 8 history text book in West Bengal has described freedom fighters who sacrificed their life for India as terrorists. The textbook published by the We... By: Zee News … Continue reading →

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The Spanish DNA – Video

Posted: Published on August 10th, 2014

The Spanish DNA ADN Espaola. By: The Ignorant Killer … Continue reading →

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Unfranchise DNA “Convert Spending Into Earning”| JR Ridinger – Video

Posted: Published on August 10th, 2014

Unfranchise DNA "Convert Spending Into Earning"| JR Ridinger Shopping Annuity Business Building * The Shopping Annuity * Creating duplication driving the Shopping Annuity down lines of * ABC Pattern/ One Right One Wrong * Bean * Clock... By: MarketAmerica … Continue reading →

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Mikulski Cuts Ribbon at State-of-the-art Advanced Chemistry Laboratory at Aberdeen Proving Ground – Video

Posted: Published on August 10th, 2014

Mikulski Cuts Ribbon at State-of-the-art Advanced Chemistry Laboratory at Aberdeen Proving Ground On Tuesday, August 5, 2014, U.S. Senator Barbara A. Mikulski (D-Md.), Chairwoman of the Senate Appropriations Committee, participated in a ribbon cutting to ... By: SenatorMikulski … Continue reading →

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Chemistry – Planck Quantum Theory & Photoelectric Effect | askIITians – Video

Posted: Published on August 10th, 2014

Chemistry - Planck Quantum Theory Photoelectric Effect | askIITians Pankaj Singh (askIITians Faculty) explains the concept of Planck quantum theory photoelectric effect as asked in IIT JEE and medical exams. For detailed theory, visit http://www.askiitians.com/ii... By: askiitians … Continue reading →

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