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ALXA Working Its Way, CERS Awaits FDA Decision, XNCR, SGEN Look Ahead To Results

Posted: Published on August 1st, 2014

By RTT News, August 01, 2014, 12:32:00 AM EDT (RTTNews.com) - Alexza Pharmaceuticals Inc. ( ALXA ) is all set to initiate a phase 2a study of AZ-002 for the management of patients with acute repetitive seizures in the second half of 2014. The company has also identified two product candidates - AZ-008 for the acute treatment of restless legs syndrome (RLS) and AZ-009 for hypomobility, or freezing, during "off periods" in Parkinson's disease patients, which will be taken up for pre-clinical testing. ALXA closed Thursday's trading at $4.83, down 2.23%. BioTime Inc.'s ( BTX ) subsidiary OncoCyte Corp. has expanded the clinical development of its urine-based bladder cancer diagnostic test PanC-Dx by initiating a multi-site clinical trial. The trial is expected to begin enrolling patients within the next week and the goal of the trial is to compare the performance of OncoCyte's proprietary PanC-Dx bladder cancer markers to the performance of cystoscopy. OncoCyte is initially focusing its efforts on developing PanC-Dx diagnostic products for use in detecting breast, bladder, and lung cancers. BTX closed Thursday's trading at $2.54, down 3.79%. Cerus Corp. ( CERS ) expects FDA decision on the premarket approval application for INTERCEPT Platelets as early as … Continue reading →

Posted in FDA Stem Cell Trials | Comments Off on ALXA Working Its Way, CERS Awaits FDA Decision, XNCR, SGEN Look Ahead To Results

Early stem cell transplant may cure "bubble boy" disease

Posted: Published on August 1st, 2014

"Bubble boy" David Vetter lived in a protective environment designed by NASA engineers. He died of complications after receiving a bone marrow transplant in 1984, at the age of 12. Baylor College of Medicine Photo Archives Babies born with so-called "bubble boy" disease can often be cured with a stem cell transplant, regardless of the donor -- but early treatment is critical, a new study finds. Severe combined immunodeficiency (SCID), as the condition is medically known, actually refers to a group of rare genetic disorders that all but eliminate the immune system. That leaves children at high risk of severe infections. The term "bubble boy" became popular after a Texas boy with SCID lived in a plastic bubble to ward off infections. The boy, David Vetter, died in 1984 at the age of 12, after an unsuccessful bone marrow transplant -- an attempt to give him a functioning immune system. 15 Photos Immune disorder forced David Vetter to live in bubble - but breakthroughs from his story now enable similar kids to live free In the best-case scenario, a child would get stem cells -- the blood-forming cells within bone marrow -- from a sibling who is a perfect match … Continue reading →

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Chris Johnson Opens Up About Stem Cell Treatment with the MMQB

Posted: Published on August 1st, 2014

Chris Johnson was once the most dynamic running back in the NFL. Now, following his move from the Tennessee Titans to the New York Jets, he's hoping cutting-edge medical treatment can help him return to those previous levels of production and extend his career. Jenny Vrentas of The MMQB reports Johnson underwent stem-cell treatment as part of his recovery from an injury to his left knee. Dr. James Andrews, who's well known for his work with athletes across the sports spectrum, handled the procedure. The three-time Pro Bowl ball-carrier explained he suffered meniscus damage in Week 3 last season, but he decided to fight through the injury. While he ended up playing in all 16 games, he certainly didn't look like the player Titans fans once knew. At 28, he's entering a period when most running backs begin to fade due to the cumulative damage after years of absorbing hits and general fatigue. Johnson hopes the treatment can help him avoid that drop-off. "When I tore my meniscus and played the season out, through the wear and tear, I lost a lot of cartilage," he told Vrentas. "When you put the stem cells in, it might be able to help … Continue reading →

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Mosaicism: Study clarifies parents as source of new disease mutations

Posted: Published on July 31st, 2014

PUBLIC RELEASE DATE: 31-Jul-2014 Contact: Glenna Picton picton@bcm.edu 713-798-4710 Baylor College of Medicine HOUSTON (July 31, 2014) Scientists have long speculated that mosaicism a biological phenomenon, in which cells within the same person have a different genetic makeup plays a bigger role in the transmission of rare disease mutations than is currently known. A study conducted by an international team of scientists led by Baylor College of Medicine sheds new light on the frequency of mosaicism in genomic disorders and its influence on recurrence risk. The study, which was published today in the American Journal of Human Genetics, also included scientists from the University of Leuven in Belgium, St. George's Healthcare Trust in London, Radbound University Medical Center in Nijmegen, Netherlands, the Institute of Mother and Child in Warsaw, Poland, and Trinity University in San Antonio, Texas. One human, multiple genomes With recent advances in genome technology, it is becoming increasingly apparent that a human individual is made up of a population of cells, each with its own "personal genome," said Dr. James Lupski, the Cullen Professor of Molecular and Human Genetics at Baylor, and a senior and corresponding author on the report. "Before this study, we understood very little … Continue reading →

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“Genetics”, Supernumerary Chromosomes – Video

Posted: Published on July 31st, 2014

"Genetics", Supernumerary Chromosomes By: MyCyberCollege … Continue reading →

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Developments in Genetics and Genomics in Neurology: Wendy Chung, MD, PhD – Video

Posted: Published on July 31st, 2014

Developments in Genetics and Genomics in Neurology: Wendy Chung, MD, PhD Wendy Chung, MD, PhD is associate professor of pediatrics and medicine at Columbia University, where she directs the clinical genetics program and performs human genetic research. She leads... By: Center for ELSI Research on Psychiatric, Neurologic Behavioral Genetics … Continue reading →

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Practical Importance of Human Evolution – Genetics, Phylogenetics & Health – Natural Selection – Video

Posted: Published on July 31st, 2014

Practical Importance of Human Evolution - Genetics, Phylogenetics Health - Natural Selection Practical Importance of Human Evolution" is a free online course on Janux that is open to anyone. Learn more athttp://janux.ou.edu. Created by the University of Oklahoma, Janux is an interactiv... By: Janux … Continue reading →

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Golden times for genetics firm

Posted: Published on July 31st, 2014

Beef + Lamb New Zealand Genetics is developing research and development genetic research projects and tools to provide additional genetic gains for sheep and beef farmers. Photo from SRL Files The sheep and beef sector stands to gain by a potential $845 million in added value during the next 20 years once a new Dunedin-based genetics research and development entity hits its stride. Yvonne O'Hara reports. Upgrading the Sheep Improvement Limited (SIL) database, developing a ram and bull selection app, and contracting out genetics research projects for both sheep and beef are expected to begin later this year for the Dunedin-based Beef + Lamb Genetics (BLNZG). BLNZG signed a $15 million funding contract for the next five years with the Ministry of Business, Innovation and Employment earlier this month. The balance of BLNZG's $44 million five-year budget will come from sheep and beef farmers and the wider red meat industry. BLNZG general manager Graham Alder, of Dunedin, said the contract signing meant it could move ahead with its research and development programmes between now and Christmas. ''The next few months are going to be busy,'' Mr Alder said. ''We intend to employ an additional one or two people [at this … Continue reading →

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Cancer diagnostic employees share their stories of how cancer has shaped them

Posted: Published on July 31st, 2014

photo courtesy/cancer genetics, inc. Employees at Cancer Genetics, Inc., are on the cutting edge of developing cancer tests, and many employees have personal stories of their own cancers and those of family members who have battled the cancers the company addresses. Cancer Genetics, Inc., a DNA-based cancer diagnostics company that researches cancer tests and has five patents for hematological, kidney, renal and cervical cancer tests, is in a unique position to have several employees who are fighting cancer or have family members who battled the disease. For Jane Houldsworth, CGI's vice president of research and development, after 20 years of working in the field, the pioneering cancer researcher was diagnosed with follicular lymphoma (FL) with diffuse large B-cell lymphone (DLBCL). Diagnosed in 2010, Houldsworth started treatment immediately. Approximately 40-50 percent of FL cases transform into DLBCL, which is treated with Rituximab - a drug that has revolutionized treatment of DLBCL. "I felt a lump in my neck that didn't go down," Houldsworth said. "I knew it wasn't something that I had done, as it's just the luck of the draw, although there could be [cancer] incidents where people were exposed to insecticides and pesticides." She got a fine needle aspirate, … Continue reading →

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Scientists push for GMO adoption in Ghana

Posted: Published on July 31st, 2014

Business News of Thursday, 31 July 2014 Source: Graphic Online Two Ghanaian research scientists made a case for Ghana to adopt genetic engineering (GE) or genetically modified organisms (GMOs) instead of sticking to the conventional method of breeding. While agreeing that conventional plant breeding had been going on for hundreds of years and had dramatically increased the productivity and quality of plants for food, feed and fibre, they maintained that it could no longer be sustained. At the opening of a three-day symposium, organised by the Ghana Academy of Arts and Sciences (GAAS) on GMOs last Monday, Dr Ibrahim Dzido Kwasi Atokple, a researcher at the Savannah Agricultural Research Institute (SARI), Tamale, said Conventional breeding is the basis, but with that alone we cannot make progress. According to Dr Atokple, practising conventional breeding could no longer be done exclusively, in view of the population explosion and developments that are taking up the arable lands. So we need to combine all biotechnological tools to increase the productivity of the few lands that are left. He said although the USA depended on hybrids for maize till the 1990s, the trend changed for more improved yields by adopting GMOs (inserting genes to improve … Continue reading →

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