PUBLIC RELEASE DATE: 28-Jul-2014 Contact: Jeffrey Norris jeffrey.norris@ucsf.edu 415-502-6397 University of California - San Francisco A new stem-cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to UC San Francisco scientists who reported the findings in the current edition of Cell. The work builds on a strategy that involves reprogramming adult cells back to an embryonic state in which they again have the potential to become any type of cell. The efficiency of this process may soon increase thanks to the scientists' identification of biochemical pathways that can inhibit the necessary reprogramming of gene activity in adult human cells. Removing these barriers increased the efficiency of stem-cell production, the researchers found. "Our new work has important implications for both regenerative medicine and cancer research," said Miguel Ramalho-Santos, PhD, associate professor of obstetrics, gynecology and reproductive sciences and a member of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, who led the research, funded in part by a prestigious NIH Director's New Innovator Award. The earlier discovery that it was possible … Continue reading
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