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Citalopram increases the differentiation efficacy of BMSCs into neuronal-like cells

Posted: Published on July 11th, 2014

PUBLIC RELEASE DATE: 10-Jul-2014 Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research There is evidence that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. Dr. Javad Verdi and his team, Tehran University of Medical Sciences, Iran proposed that citalopram, a selective serotonin reuptake inhibitor, can increase the efficacy of bone marrow mesenchymal stem cells (BMSCs) differentiating into neuronal-like cells. Experimental results confirmed that citalopram can improve the neuronal-like cell differentiation of BMSCs by increasing cell proliferation and survival while maintaining their neuronal characteristics. These results were published in Neural Regeneration Research (Vol. 9, No. 8, 2014). ### Article: "Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells" by Javad Verdi1, 2, Seyed Abdolreza Mortazavi-Tabatabaei1, 2, Shiva Sharif 2, 3, Hadi Verdi2, Alireza Shoae-Hassani1, 2 (1 Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2 Department of Stem Cells and Tissue Engineering, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 3 Department of Tissue Engineering, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran) … Continue reading →

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ADSCs transplantation promotes neurogenesis in Alzheimer's disease

Posted: Published on July 11th, 2014

PUBLIC RELEASE DATE: 10-Jul-2014 Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research Recent evidence has demonstrated that transplantation of mesenchymal stem cells can stimulate neurogenesis in the brain of adult rat or mouse models of Alzheimer's disease (AD) and improve tissue and function injury under the condition of cerebral ischemia. Few studies are reported on the therapeutic effect of adipose-derived stem cells (ADSCs) transplantation in mice with AD and on the effect on oxidative injury and neurogenesis in the brain of AD mice. Dr. Yufang Yan and her team, School of Life Sciences, Tsinghua University, China transplanted ADSCs into the hippocampus of APP/PS1 transgenic AD model mice. ADSCs transplantation reduced oxidative stress, promoted neurogenesis in both the subgranular and subventricular zone, and thereby improved the cognitive impairment in APP/PS1 transgenic AD mice. These results provide theoretical and experimental evidence for AD treatment with ADSCs. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014). ### Article: " Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice," by Yufang Yan1, Tuo Ma1, Kai Gong1, Qiang Ao2, Xiufang Zhang1, Yandao Gong1 (1 State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life … Continue reading →

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Patient-specific stem cells and personalized gene therapy

Posted: Published on July 11th, 2014

Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem (iPS) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing. Using this approach, researchers led by Stephen H. Tsang, MD, PhD, showed that a form of RP caused by mutations to the gene MFRP (membrane frizzled-related protein) disrupts the protein that gives retinal cells their structural integrity. They also showed that the effects of these mutations can be reversed with gene therapy. The approach could potentially be used to create personalized therapies for other forms of RP, as well as other genetic diseases. The paper was published recently in the online edition of Molecular Therapy, the official journal of the American Society for Gene & Cell Therapy. "The use of patient-specific cell lines for testing the efficacy of gene therapy to precisely correct a patient's genetic deficiency provides yet another tool for advancing the field of personalized medicine," said Dr. Tsang, the Laszlo Z. Bito Associate … Continue reading →

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Breakthrough in bid to cure blindness as scientists identify gene linked to inherited disease

Posted: Published on July 11th, 2014

Advances in plan for individual gene therapies for leading cause of blindness Scientists use stem cells to investigate causes of degenerative eye disease Two patients with retinitis pigmentosa had mutations in a certain gene New gene therapy was used to rescue vision of mice with the same condition By Julian Robinson Published: 06:49 EST, 11 July 2014 | Updated: 07:16 EST, 11 July 2014 Scientists have moved closer to a breakthrough in 'personalised' treatments for a leading cause of blindness. Researchers have stepped up their bid to create individual gene therapies for one of the factors that triggers inherited vision loss. They used 'induced' stem cells - taken from ordinary skin cells - to investigate patient-specific causes of the degenerative eye disease retinitis pigmentosa (RP), which leads to blindness or severe visual impairment. Scientists have moved closer to a breakthrough in 'personalised' treatments for a leading cause of blindness By testing retinal cells created from the stem cells in the laboratory, they linked RP in two patients to mutations in a gene called MFRP. The scientists then used a virus to deliver normal copies of the gene into the retinal cells and restore their function. The rest is here: Breakthrough … Continue reading →

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Autologous Stem Cell Transplants – Part 1 – Video

Posted: Published on July 11th, 2014

Autologous Stem Cell Transplants - Part 1 Diana Moore from Mater Health Services talks about the autologous stem cell transplant process - a common treatment option for people with lymphoma, myeloma,... By: LeukaemiaQld … Continue reading →

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Autologous Stem Cell Transplants – Part 4 – Video

Posted: Published on July 11th, 2014

Autologous Stem Cell Transplants - Part 4 Diana Moore from Mater Health Services talks about the autologous stem cell transplant process - a common treatment option for people with lymphoma, myeloma,... By: LeukaemiaQld … Continue reading →

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Albion Park man heads to Russia for risky op

Posted: Published on July 11th, 2014

July 11, 2014, 9 p.m. Multiple sclerosis sufferer Troy Eccleston will travel to Russia in September for risky but potentially life-saving treatment. Troy Eccleston, with fiancee Ainslie Sackey, is ready to go to Russia. Picture: SYLVIA LIBER Multiple sclerosis sufferer Troy Eccleston will travel to Russia in September for risky but potentially life-saving treatment. A controversial stem cell transplant is the last hope for the 47-year-old Albion Park Rail man whose symptoms have worsened in the last two years, leaving him confined to a wheelchair. Mr Eccleston was not eligible for a Sydney trial of haematopoietic stem cell transplantation due to his age and the advanced nature of his MS, but he has been accepted for treatment at the Pirogov Centre in Moscow. His fiancee Ainslie Sackey and family and friends are now busy fund-raising, with a target of $70,000 to pay for the 30-day treatment and associated transport costs. "Over the next two years it is expected I will grow a new immune system with no memory of MS." "The treatment involves injections to stimulate my bone marrow to release millions of stem cells, removing the cells and freezing them," Mr Eccleston said. "I will then be given large … Continue reading →

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Dr. Jeffrey Kenkel Examines Surgical Wound Healing in Massive Weight Loss Patients

Posted: Published on July 11th, 2014

Dallas, Texas (PRWEB) July 10, 2014 Dr. Jeffrey M. Kenkel, Dallas plastic surgeon, Professor and Vice-Chairman of the Department of Plastic Surgery at UT Southwestern Medical Center, recently published a correlative study in the "Aesthetic Surgery Journal," a publication issued by the American Society for Aesthetic Plastic Surgery. The paper, "The Effect of Massive Weight Loss Status, Amount of Weight Loss, and Method of Weight Loss on Body Contouring Outcomes" investigated the likelihood of complications in patients who undergo body contouring after massive weight loss (MWL) over 50 pounds. "This is one of the first large-scale studies comparing outcomes in patients losing significant amount of weight via surgical and non-surgical means," explained Dr. Kenkel, who sees many of these patients in his Dallas plastic surgery clinic. "The study reviewed data from 450 body contouring patients, including 124 who had undergone massive weight loss by various methods before the procedure." Dr. Kenkel and his peers conducted a statistical analysis to identify risk factors and determine the probability of patients experiencing healing issues or complications after their surgery. Patients included men and women in all age groups who had undergone various body contouring procedures, including body lifts, tummy tucks, thighplasty, arm lifts, … Continue reading →

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Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc.

Posted: Published on July 11th, 2014

Poway, CA (PRWEB) July 10, 2014 Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the leading Regenerative Veterinary Medicine company, is proud to announce the relaunch of his highly informative blog, now named Stem Cells for Pets, launching with a new series called What are Stem Cells? Dr. Harmans purpose for blogging is to give an honest and straightforward foundation in the basics of stem cell therapy so that pet owners can make an educated decision on the right type of treatment when considering regenerative medicine. A veterinarian by trade, Dr. Harman is in his third decade of biotechnology entrepreneurial-ship, has overseen the completion of more than a thousand contract research projects in veterinary and human products, and has led a handful of companies to licensing and sale. Harmans current company, Vet-Stem, was the first to provide an adipose-derived stem cell service to veterinarians for their patients. As a pioneer in the field, Vet-Stem now holds exclusive licenses to over 50 patents, and continues blazing the trail for clinical trials and scientific studies. Dr. Harman leverages this experience and Vet-Stems over 10,000 horse, dog, cat, and exotic animal cases in the last decade to present supporting data, not only … Continue reading →

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The Sims 3 | Perfect Genetics Challenge Part 11: Walking Toddlers – Video

Posted: Published on July 10th, 2014

The Sims 3 | Perfect Genetics Challenge Part 11: Walking Toddlers In this part, we teach the twins how to walk and find out we're pregnant! Backstory: "Once upon a time, the Mighty Player sent a Sim to live in the world whe... By: simplyapril … Continue reading →

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