July 8, 2014 Image Caption: DNA-origami. Credit: Bjrn Hgberg Karolinska Institutet Researchers at Karolinska Institutet in Sweden have headed a study that has provided new knowledge about the EphA2 receptor, which is significant in several forms of cancer. This is important knowledge in itself but just as important is how this study, which is published in the highly respected journal Nature Methods today, was conducted. The researchers used the method of DNA origami, in which a DNA molecule is shaped into a nanostructure, and used these structures to test theories about cell signalling. It was previously known that the EphA2 receptor played a part in several forms of cancer, such as breast cancer. The ligand, i.e., the protein that communicates with the receptor, is known as an ephrin molecule. Researchers have had a hypothesis that the distance between different ligands in this case the distance between ephrin molecules affects the level of activity in the communicating receptor of the adjacent cells. The Swedish researchers set out to test this hypothesis. They used DNA building blocks to form a stable rod. This has then been used as a very accurate measure of the distance between molecules. We use DNA as the … Continue reading
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