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Scientists withdraw report on simpler stem cells

Posted: Published on July 2nd, 2014

NEW YORK U.S. and Japanese scientists who reported that they'd found a startlingly simple way to make stem cells withdrew that claim Wednesday, admitting to "extensive" errors in the research. In two papers published in January in the journal Nature, the researchers said that they'd been able to transform ordinary mouse cells into versatile stem cells by exposing them to a mildly acidic environment. Someday, scientists hope to harness stem cells to grow replacement tissue for treating a variety of diseases. While researchers have long been able to perform such transformations with a different method, the newly reported technique was far simpler, and the papers caused a sensation and some skepticism in the research community. They were also widely reported in the media, including by The Associated Press. But before long, the government-funded Riken Center for Developmental Biology in Japan accused one of its scientists, Haruko Obokata, of falsifying data in the research. Obokata, the key author of the papers, defended the results during a televised news conference in April while apologizing for using wrong and altered images in the published reports. She also said she opposed withdrawing the papers, a process called retraction, and the 30-year-old attributed her mistakes … Continue reading →

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Scientists rally around beleaguered Japanese research centre

Posted: Published on July 2nd, 2014

FRANCK ROBICHON/EPA/CORBIS Masatoshi Takeichi, who has led The RIKEN CDB since its founding in 2000, has received excessive criticism, some international researchers say. Researchers around the globe are voicing support for a Japanese research centre that faces dismantlement after one of its researchers was found guilty of scientific misconduct. The controversy swirls around Haruko Obokata, a biochemist at the RIKEN Center for Developmental Biology (CDB) in Kobe, who was found guilty of manipulating data in a paper, published in Nature, that claims a recipe for making embryonic-like stem cells with a technology called stimulus-triggered acquisition of pluripotency (STAP). (Natures news and comment team is editorially independent of its research editorial team.) In April, RIKEN launched an independent reform committee to advise on how the CDB can avoid such incidents in the future. In a 29-page report released on 12 June, the panel advised quickly dismantling the 14-year-old centre. A caveat included in the report that a new organization might be built in its place did not appease concerned scientists. At least 160 have written to RIKEN management in support for one of the worlds outstanding research institutes in the area of developmental and cell biology, in the words of stem-cell … Continue reading →

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Stem cell type resists chemotherapy drug

Posted: Published on July 2nd, 2014

A new study shows that adipose-derived human stem cells, which can become vital tissues such as bone, may be highly resistant to the common chemotherapy drug methotrexate (MTX). The preliminary finding from lab testing may prove significant because MTX causes bone tissue damage in many patients. MTX is used to treat cancers including acute lymphoblastic leukemia, the most common form of childhood cancer. A major side effect of the therapy, however, is a loss of bone mineral density. Other bone building stem cells, such as bone marrow derived stem cells, have not withstood MTX doses well. "Kids undergo chemotherapy at such an important time when they should be growing, but instead they are introduced to this very harsh environment where bone cells are damaged with these drugs," said Olivia Beane, a Brown University graduate student in the Center for Biomedical Engineering and lead author of the study. "That leads to major long-term side effects including osteoporosis and bone defects. If we found a stem cell that was resistant to the chemotherapeutic agent and could promote bone growth by becoming bone itself, then maybe they wouldn't have these issues." Stem cell survivors Originally Beane was doing much more basic research. She … Continue reading →

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Medical sleuths seek patients with mystery diseases, offer new tools

Posted: Published on July 2nd, 2014

Everyone loves a medical mystery, except the afflicted patient and his or her family who shuffle from doctor to doctor in search of an explanation for a disorder whose name, origin, prognosis and cure are all unknown. Now, the National Institutes of Health have underwritten a nationwide "whodunnit" campaign, with a $43 million-initiative to fund the diagnosis and exploration of undiagnosed, unrecognized and misunderstood diseases. Think of it as a bid to clear a backlog of medical cold cases, using dazzling new tools now at the disposal of medical sleuths. Think of it also as an opportunity for scientists to glean new insights into the human genome and its role in causing -- and perhaps curing -- disease. This week, the NIH announced the expansion of its Undiagnosed Disease Network, which by the summer of 2017 is expected to enroll at least 300 new patients with mysterious and intractable conditions per year, nationwide. The diseases that afflict these patients are conditions that have stumped even skilled physicians. Doctors may fail to recognize the conditions because they are rarely seen, have never been described in the medical literature or are rare forms of more common diseases. Some may be caused outright … Continue reading →

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Stem Cell Therapy | Regenerative Medicine

Posted: Published on July 2nd, 2014

Call A Stem.MD Health Advisor Now 561-463-6333 Stem.MD National Regenerative Medical Practice Mets signs Bartolo Colon, 41, to a 2 year $20mm deal after being treated with the Stem MD proprietary BMAC procedure There was a time when, due to shoulder and elbow injueries, Colon, didn't know if he would ever pitch in the majors again. Stem MDs foundation is built on the combined knowledge of the most trusted and effective sources and practitioners in regenerative medicine today. Leveraging our vast resources and collective experience, Stem MD offers a treatment plan tailored specifically to each patients needs. Our Health Consultants carefully assess your case and work with you and our doctors to ensure you get the treatment you deserve. We are committed to the best possible solution, which means knowing where breakthrough regenerative medicine can be used effectively, and only performing invasive surgery as a last resort. Read more about the Stem MD patient experience. Like all Stem.MD physicians, Dr. Purita prides himself on offering the latest surgical and non-surgical techniques to our clients, which range from celebrities to weekend athletes to the elderly. Read more about Stem MD. In 2010, MLB player, Bartolo Colon received stem cell injections from … Continue reading →

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Global Stem Cells Group Subsidiary Regenestem Announces Grand Opening of State-of-the-Art Regenestem Asia Stem Cell …

Posted: Published on July 2nd, 2014

Miami (PRWEB) July 01, 2014 Global Stem Cells Group announced the grand opening of Regenestem Asia in Manila, Philippines, adding a new state-of-the-art clinic to the international stem cell medicine company's growing worldwide presence. With clinics in Miami, New York, Los Angeles and Dubai, Regenestem Asia now offers the same comprehensive stem cell treatments and experienced medical staff that have fueled the company's worldwide growth. The launch of Regenestem Asia is a collaborative effort between Global Stem Cells Group and Eric Yalung, M.D. of the Cosmetic Surgery Institute-Manila, Inc., a prominent plastic surgeon committed to taking stem cell medicine, research and practice in the Philippines to a world-class level. The first Regenestem brand clinic in the Philippines, Regenestem Asia is a 22,000 square foot facility with a focus on offering the most advanced protocols in cosmetic cellular medicine to patients from around the world. Under Yalung's leadership as Regenestem Medical Director, patients will receive the latest and least-invasive techniques in Stem Cell medicine available. Yalung is joined by a team of talented stem cell specialists to provide world-class patient treatment and follow-up care under the Regenestem brand. In addition to cosmetic treatments, Regenestem offers stem cell treatments for arthritis, autism, … Continue reading →

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Studies Test Effectiveness and Safety of Stem Cell Treatment for Urinary Incontinence

Posted: Published on July 2nd, 2014

Durham, NC (PRWEB) July 01, 2014 Medication and minimally invasive surgery to implant a sling can provide relief for millions of people who suffer from stress urinary incontinence (SUI), but not everyone responds to these therapeutic methods. A new study in the current STEM CELLS Translational Medicine tests the safety and effectiveness of stem cells as an alternative SUI treatment. SUI results when the pelvic floor muscles, which support the bladder and urethra, weaken to the point that the muscles are not able to prevent urine from flowing when pressure is placed on the abdomen, such as when the person laughs or coughs. It occurs most often in women, due to childbirth and pregnancy. Tissue engineering offers an attractive method to regenerate sphincter muscle, explained the studys corresponding author, Kirsi Kuismanen, from the department of obstetrics and gynecology at Tampere University Hospital (TUH) in Finland. She and her TUH colleagues teamed up with researchers from the Adult Stem Cell Group of BioMediTech in Tampere and the University of Twente in the Netherlands on the study. Previously, various different cell sources, such as skeletal muscle-derived stem cells (SkMSCs), mesenchymal stem cells derived from bone marrow (BMSCs) and adipose stem cells (ASCs), … Continue reading →

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Adults stop anti-rejection drugs after stem-cell transplant reverses sickle cell disease

Posted: Published on July 2nd, 2014

PUBLIC RELEASE DATE: 1-Jul-2014 Contact: Krysten Carrera NIDDKMedia@mail.nih.gov 301-496-3583 NIH/National Institute of Diabetes and Digestive and Kidney Diseases Adults stop anti-rejection drugs after stem-cell transplant reverses sickle cell disease NIH trial success suggests a new treatment option for older, sicker patients Half of patients in a trial have safely stopped immunosuppressant medication following a modified blood stem-cell transplant for severe sickle cell disease, according to a study in the July 1 issue of the Journal of the American Medical Association. The trial was conducted at the National Institutes of Health's Clinical Center in Bethesda, Maryland, by researchers from NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute. The transplant done in the study reversed sickle cell disease in nearly all the patients. Despite having both donor stem-cells and their own cells in their blood, the patients stopped the immunosuppressant medication without experiencing rejection or graft-versus-host disease, in which donor cells attack the recipient. Both are common, serious side effects of transplants. "Typically, stem-cell recipients must take immunosuppressants all their lives," said Matthew Hsieh, M.D., lead author on the paper and staff clinician at NIH. "That the patients who discontinued this … Continue reading →

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Research team pursues techniques to improve elusive stem cell therapy

Posted: Published on July 2nd, 2014

Stem cell scientists had what first appeared to be an easy win for regenerative medicine when they discovered mesenchymal stem cells several decades ago. These cells, found in the bone marrow, can give rise to bone, fat, and muscle tissue, and have been used in hundreds of clinical trials for tissue repair. Unfortunately, the results of these trials have been underwhelming. One problem is that these stem cells don't stick around in the body long enough to benefit the patient. But Harvard Stem Cell Institute (HSCI) scientists at Boston Children's Hospital aren't ready to give up. A research team led by Juan Melero-Martin, PhD, recently found that transplanting mesenchymal stem cells along with blood vessel-forming cells naturally found in circulation improves results. This co-transplantation keeps the mesenchymal stem cells alive longer in mice after engraftment, up to a few weeks compared to hours without co-transplantation. This improved survival gives the mesenchymal stem cells sufficient time to display their full regenerative potential, generating new bone or fat tissue in the recipient mouse body. The finding was published in the Proceedings of the National Academy of Sciences (PNAS). "We are losing mesenchymal stem cells very rapidly when we transplant them into the … Continue reading →

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Ankylosing Spondylitis: Stem cell treatment after 72 hours – Video

Posted: Published on July 2nd, 2014

Ankylosing Spondylitis: Stem cell treatment after 72 hours 72 hours after treatment patient experienced great chnges in his movement. By: StemRx BioScience … Continue reading →

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