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Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

Posted: Published on July 1st, 2014

PUBLIC RELEASE DATE: 30-Jun-2014 Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-6383 Brigham and Women's Hospital Boston, MA A research collaboration between Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression. The study is published the week of June 30, 2014 in Proceedings of the National Academy of Sciences. "Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression," said Archana Swami, PhD, BWH Laboratory of Nanomedicine and Biomaterials, co-lead study author. "We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression." "There are limited treatment options for bone cancers," added Michaela Reagan, PhD, DFCI Center for Hematologic Oncology, co-lead study author. "Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone … Continue reading →

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Due to the Necessity for Resources in the Medical Spa and Aesthetic Industry, AmSpa Adds OSHA and HIPAA Compliance …

Posted: Published on July 1st, 2014

Chicago, Illinois (PRWEB) June 30, 2014 Per the American Med Spa Association (AmSpa), considering the recent surge in popularity of medical spas, it will not be long before OSHA begins making their presence known and HIPAA violations may become a thing of the present. If a medical spa is not prepared, the results can be financially devastating. Per Steve Wilder of Sorensen, Wilder & Associates who presented on OSHA compliance within a medical spa setting at AmSpas Southeastern Regional Workshop, It only takes one OSHA visit to shut your medical spa down. There are critical programs needed within a medical spa setting to remain OSHA complaint, which most medical spas are not even aware of. If a med spa is to be found non-compliant it to expect payment penalties." Most penalties start at around $1,500 per violation, the law allows them to start as high as $7,500 per violation and repeat violations can start at $75,000. Sorensen, Wilder & Associates is about to release an OSHA self-assessment tool that Steve created for the medical spa industry. Medical spas can complete the assessment which will then be scored by each section and returned with a report that indicates where they are … Continue reading →

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Lutronic Announces the New Gold Handpiece for Spectra; Expanding the Impressive Treatment Options Even Further

Posted: Published on July 1st, 2014

Fremont, CA (PRWEB) July 01, 2014 Lutronic, a global leader of lasers and therapeutic devices for aesthetic and medical applications, announced today that the new Gold Handpiece for SPECTRA is now available in the United States, expanding the already robust workhorse to even more clinical applications. The gold 585 nm handpiece now available on the Spectra Q-switched laser, has proven to significantly reduce the purplish-red color from acne lesions in studies conducted both at our clinic and international sites. Weve found the color to be actually more distressing than the acne itself, to many of our patients. Stated Dr. Gilly Munivalli, Medical Director and Founder of Dermatology Laser and Vein Specialists, Its great to finally have a no-downtime, painless treatment to resolve this issue that can occur during acne outbreaks and typically persists for many months after active acne has resolved. The gold handpiece has proven very beneficial for our patients and our practice. The Gold handpiece and software upgrade provide users expanded settings and applications, allowing physicians to get superior reduction in redness that can remain after acne is resolved. The new settings and specialized handpiece produce the ideal combination of low fluence and peak power for the 585 … Continue reading →

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Her own stem cells saved her from hip replacement

Posted: Published on July 1st, 2014

Apollo Health City team did autologous stem cell procedure to save both the hip joints Hyderabad, June 30: A team of doctors from a city hospital have harvested stem cells of a person using bone morrow from the pelvis area to replace some dead tissues in the hip. In this process, they saved the patient from undergoing a hip replacement. The Apollo Health City team, headed by orthopaedic specialist Paripati Sharat Kumar, diagnosed a 39-year-old woman to be suffering from Avascular Necrosis, making her writhe with pain in her two hip joints. Her condition would require undergoing a replacement of hips. After assessing her condition, the team has decided to go for autologous stem cell procedure (where donor and the receiver is the same person) to save both the hip joints. The minimally invasive procedure involved taking bone marrow aspirate from the patients pelvis. Stem cells were harvested from the aspirate, through a process that takes about 15 minutes. Stems cells were planted in the area of damage under fluoroscopy control following core decompression, Sharat Kumar said here in a statementon Monday. He felt that autologous stem cell treatments could edge out joint replacement procedures to a large extent in … Continue reading →

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Stem Cell Clinical Trials – Canadian Stem Cell Foundation

Posted: Published on July 1st, 2014

The therapeutic potential of stem cells has so profoundly changed the landscape of medical research that it has spawned an entirely new field regenerative medicine. There is indeed a great deal of promise, but also a tendency to think that a cure is just around the corner. The path from research to the clinic is often long and complicated, with many small advances. Our aim is to present an objective view of the most important advances, to provide a foundational knowledge against which to read and evaluate new research as it emerges. A recent Canadian report examined the state of novel stem cell clinical trials around the world. Find out more here. Generally, it is helpful to understand four different approaches to using stem cells for clinical benefit, in addition to their still critical role in understanding the disease process. Stem cell transplantation Cellular therapy Tissue regeneration Drug discovery General information on clinical trials Where can I find out about ongoing stem cell therapies or clinical trials? Stem cell transplantation exploits the special characteristics of stem cells to multiply indefinitely and to become other cells required by the body. For example, stem cells that reside in the bone marrow or … Continue reading →

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Verastem Inc.'s Upcoming Catalysts

Posted: Published on July 1st, 2014

Verastem (NASDAQ: VSTM) is having its annual research and development day in a few weeks, on July 10. Call it a catalyst to announce catalysts. We might even get some new data from the cancer-stem-cell expert. Verastem's lead drug, VS-6063, targets a protein called focal adhesion kinase, or FAK, which is involved in cell survival, among other things. The biotech also has a backup compound, VS-4718 that targets FAK and a third drug that targets the PI3K/mTOR signaling pathway, which is also involved cell survival. Both pathways are up regulated in cancer cells, making them good potential targets. Verastem's drugs preferentially target cancer stem cells, which are believed to be the root of reoccurrence of cancer. Cancer treatments kill a majority of the cancerous cells, shrinking the tumors, but the cancer stem cells often survive, thereby regenerating the primary tumor. The formation of metastases -- tumors at secondary sites -- may be initiated by these cancer stem cells. When in 2015? Without a doubt, Verastem's biggest catalyst is a clinical trial called Command, testing VS-6063 in patients with mesothelioma, a form of lung cancer. The 350 to 400 patients expected to enroll in the trial have already responded to a … Continue reading →

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Human Gut Cells Become Insulin Producers in New Approach

Posted: Published on July 1st, 2014

Scientists have converted human gut cells into insulin producers by turning off a single gene in an experiment that suggests a new way forward in treating diabetes. Using a miniature model of the human intestine, only a few millimeters in size and made from stem cells, the scientists deactivated a gene in the cells tied to metabolic regulation called FOXO1. Once disabled, the cells began producing insulin. The method, described today in the journal Nature Communications, raises the possibility of replacing insulin-making pancreatic beta cells lost in diabetics by using a drug to retrain patients existing cells. While progress has been made in generating beta cells from stem cells, the method hasnt yet produced ones with all the needed functions, said Domenico Accili, the studys lead author. Plus, such cells would require transplantation. We provided a proof of principle that we can do this in human tissues and are also very excited that there is a single identifiable target to trigger this process, Accili, professor of medicine at Columbia Universitys Naomi Berrie Diabetes Research Center in New York, said in an interview. This is what the pharmaceutical industry is interested in -- make a chemical and do what we did … Continue reading →

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Autologous stem cell treatment could be the road ahead

Posted: Published on July 1st, 2014

The treatment could edge out joint replacement procedures to a large extent. Hyderabad, June 30: A team of doctors from a city hospital have harvested stem cells of a person using bone marrow from the pelvis area to replace some dead tissues in the hip. By doing this, they saved the patient from undergoing a hip replacement. The Apollo Health City team, headed by orthopaedic specialist Paripati Sharat Kumar, diagnosed a 39-year-old women suffering from Avascular Necrosis. Her condition would require undergoing a replacement of hips. After assessing her condition, the team has decided to go for the autologous stem cell procedure (where donor and the receiver is the same person) to save both the hip joints. The minimally invasive procedure involved taking bone marrow aspirate from the patients pelvis. Stem cells were harvested from the aspirate through a process that takes about 15 minutes. Stems cells were planted in the area of damage under fluoroscopy control following core decompression, Kumar said in a statement on Monday. He feels that the autologous stem cell treatment could edge out joint replacement procedures to a large extent in the days to come. The scope of this procedure in orthopaedics and sports medicine … Continue reading →

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R3 Stem Cell Clinics Expand to Southern California, Now Offering Procedures in Beverly Hills

Posted: Published on July 1st, 2014

Los Angeles, California (PRWEB) June 30, 2014 R3 Stem Cell has expanded to Southern California, and is now offering procedures in Beverly Hills to patients. The company has partnered with Beverly Hills Orthopedic Institute to now offer three different types of stem cell procedures to patients for all types of degenerative arthritis, tendonitis and ligament injuries. For more information and patient scheduling, call (310) 438-5343. R3 Stem Cell works with medical practices nationwide to offer stem cell therapy for all types of musculoskeletal conditions. The three types of procedures offered are bone marrow derived stem cell therapy, amniotic derived stem cell therapy and platelet rich plasma therapy. Said R3 CEO Bob Maguire, Patients are now benefiting from stem cell procedures by delaying or avoiding the need for joint replacement due to the amazing pain relief and regeneration possible with the procedures. We are very excited to be expanding into Southern California to help more patients and have the opportunity to work with a highly respected physician like Dr. Raj. The R3 Stem Cell partnership with Beverly Hills Orthopedic Institute brings the stem cell therapy to patients with treatment from Dr. Raj. As a Double Board Certified orthopedic doctor and a … Continue reading →

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Beverly Hills Orthopedic Institute Expands to Offering Three Stem Cell Procedure Options

Posted: Published on July 1st, 2014

Beverly Hills, California (PRWEB) June 30, 2014 The top regenerative medicine practice in Los Angeles at Beverly Hills Orthopedic Institute is now offering three options for stem cell procedures. The procedures work well for treatment of degenerative joint arthritis, tendonitis and ligament injuries. For more information and scheduling call (310) 438-5343. Stem cell therapy has become mainstream for the treatment of all types of musculoskeletal conditions, and Dr. Raj at Beverly Hills Orthopedic Institute has been at the forefront of the therapy. Several options for the treatment are now being offered which include bone marrow derived stem cell procedures and platelet rich plasma therapy. Recently, Dr. Raj has begun offered amniotic derived stem cell procedures. The material is obtained from consenting donors after scheduled c-sections, with an FDA regulated laboratory processing the material. Amniotic fluid has an incredible concentration of stem cells along with growth factors and hyaluronic acid. As a Double Board Certified orthopedic doctor and one of LAs top orthopedists, Dr. Raj said, Amniotic stem cell therapy has been an amazing procedure for my patients. What were seeing here is the ability to delay or avoid the need for joint replacement, with intense pain relief in the joints … Continue reading →

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