The U.K.s national synchrotron now has a complete cryo-EM workflow for integrative structural biology to explore essential biological questions at the atomic and molecular scale. Hillsboro, Ore. and Oxfordshire, U.K. FEI (NASDAQ: FEIC) today announced its largest order for Life Sciences - Diamond Light Source, one of the most advanced synchrotron light sources in the world, has ordered two Titan Krios cryo transmission electron microscopes (TEMs), a Scios DualBeam FIB/SEM (focused ion beam/scanning electron microscope) and a Talos cryo-TEM. These microscopes form the core of the electron biology facility (EBIC) that will provide Diamond with a complete cryo-electron microscopy (EM) workflow that will be used in conjunction with other structural biology techniques to enable new insights into viruses and cellular proteins. Professor David Stuart, director for Life Sciences at Diamond Light Source, states, X-ray diffraction (XRD) and nuclear magnetic resonance (NMR) are extremely powerful techniques that can resolve atomic-scale structure, but can only be applied to a subset of biological molecules and complexes. Cryo-EM can resolve structures down to the sub-nanometer, molecular-scale, and can look at just about anything, including large multimolecular complexes. In the simplest sense, integrative structural biology uses cryo-EM to provide the overview, and XRD and NMR … Continue reading
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