PUBLIC RELEASE DATE: 4-Jun-2014 Contact: Jeffrey Norris jeffrey.norris@ucsf.edu 415-502-6397 University of California - San Francisco A 14-year-old boy's turnaround and quick recovery after mysteriously being stricken by brain-inflaming encephalitis -- which led to him being hospitalized for six weeks and put into a medically induced coma after falling critically ill -- shows that the newest generation of DNA analysis tools can be harnessed to reveal the cause of a life-threatening infection even when physicians have no suspects. The quick diagnosis and successful treatment of the adolescent just 48 hours after cerebrospinal spinal fluid and blood were received for analysis portends the broader application of powerful, "next-generation sequencing" (NGS) techniques in solving infectious disease mysteries, not only in cutting-edge research labs, but also in clinical laboratories accessible to hospital physicians everywhere, according to Charles Chiu, MD, PhD, a professor of laboratory medicine at UC San Francisco (UCSF). Chiu is senior author of the case study, published online in the New England Journal of Medicine (NEJM) on June 4, 2014. The workflow pipeline developed in Chiu's UCSF laboratory to streamline genetic sleuthing of disease pathogens with NGS dramatically cut the time between sample collection and actionable diagnosis and helped a medical team … Continue reading
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