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New Initiatives to Protect Participants in Gene Therapy Trials

Posted: Published on May 8th, 2014

FOR IMMEDIATE RELEASE Tuesday, March 7, 2000 Contact: FDA Press Office (301) 827-6250 NIH Press Office (301) 496-5787 New Initiatives to Protect Participants in Gene Therapy Trials FDA's clinical trials monitoring plan addresses emerging evidence that the monitoring by study sponsors of several recent gene therapy trials has been less than adequate. To buttress the rigor of the oversight, FDA will require that sponsors of gene therapy trials routinely submit their monitoring plans to the FDA. FDA will review these monitoring plans and seek modifications as warranted to improve the quality of monitoring. FDA will also perform surveillance and "for cause" inspections of clinical trials to assess whether the plans are being followed and whether monitoring has been adequate to identify and correct critical problems. The sponsors will also have to address such issues as the experience and training of the monitors and the adequacy of the monitoring in their plans. In addition, NIH and FDA will seek to enhance the conduct of gene therapy trials by convening a conference of investigators at which the appropriate monitoring practices will be discussed by the most experienced professionals in the field. Clinical trial monitoring is a powerful tool in enhancing the safety … Continue reading

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Harvard researchers find protein that could reverse the aging process

Posted: Published on May 8th, 2014

Researchers from the Harvard Stem Cell Institute (HSCI) have shown that injections of a protein dubbed GDF11, when administered to older mice, appear to cause a reversal of many signs of aging. Analysis showed that every major organ system tested displayed signs of improvement, with the protein even appearing to reverse some of the DNA damage which is synonymous with the aging process itself. The protein GDF11 is found in humans as well as mice, and is now being considered for possible human testing due to its surprising and apparently regenerative properties. A previous study had focused on examining the hearts of mice the equivalent of 70 human years old. The mice were regularly exposed to the blood of younger mice whose blood carried a higher concentration of GDF11. Ordinarily the hearts of older mice are enlarged and weakened, however results from the previous study displayed that, thanks to the GDF11 protein present in the blood of the younger mice, the hearts of the elderly mice reduced in size, making them appear younger and healthier. The changes were not purely aesthetic however, with the mice displaying an increased ability to exercise for prolonged periods of time. The most recent set … Continue reading

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Pushing the boundaries of stem cells

Posted: Published on May 8th, 2014

PUBLIC RELEASE DATE: 7-May-2014 Contact: Lucia Lee NewsMedia@mssm.edu 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine (NEW YORK May 7) Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation. The study, published in the May issue of The Journal of Clinical Investigation, looked at ways to expand the number of hematopoietic stem cells (HSC) in the laboratory required to replenish and renew blood cells. Cord blood stem cells have the ability to rapidly divide in the presence of combinations of growth factors but they often lose their marrow-repopulating potential following cell division. Researchers looked at ways to overcome this limitation by inducing a genetic program by which a stem cell retains its full functional properties after dividing in the laboratory. "Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a single collection," said Pratima Chaurasia, PhD, Assistant Professor … Continue reading

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FOJC RADIO – DAVID CARRICO – GENETICS OF SALVATION & MARK OF THE BEAST – FOLLOWERS OF JESUS CHRIST – Video

Posted: Published on May 8th, 2014

FOJC RADIO - DAVID CARRICO - GENETICS OF SALVATION MARK OF THE BEAST - FOLLOWERS OF JESUS CHRIST THE GENETICS OF SALVATION THE MARK OF THE BEAST FOJC RADIO DAVID CARRICO FOLLOWERS OF JESUS CHRIST RADIO FOJC RADIO - DAVID CARRICO WEBSITE - http://www.fo... By: BlueRavenUSA … Continue reading

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Jurassic Genetics | Second Tech Demo (With Added Stegosaurus!) – Video

Posted: Published on May 8th, 2014

Jurassic Genetics | Second Tech Demo (With Added Stegosaurus!) Dinosaaaaauuuurs! No drama, please. Ta. Much love. Subscribe with this handy dandy link! http://bit.ly/13OT2RF Jurassic Genetics on Facebook https://www.facebook.com/JurasscGenetics... By: BestInSlot - The Home Of Dinosaur Gaming … Continue reading

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Scientists Add New Letters to Lifes Genetic Alphabet

Posted: Published on May 8th, 2014

Scientists have created the first organism with synthetic DNA that can replicate in a cell, an achievement that promises to add new letters to the genetic code underlying life on earth. In the natural world, just two chemical base pairs, known simply as A-T and C-G, constitute the building blocks of DNA in all life forms. Research published yesterday in the journal Nature describes the creation of a cell that contains a man-made base pair, dubbed d5SICS-dNAM. By expanding the natural boundaries of what constitutes life, scientists hope they can one day create new proteins that can handle a variety of chores in the body, potentially leading to unique ways to attack disease. The approach is safe, the researchers said, because it includes a chemical additive that the cell needs to survive. We created an organism that lives and stably harbors genetic information in its DNA, said Floyd Romesberg, a chemist at La Jolla, California-based Scripps Research Institute, whose laboratory created the new organism. Instead of two base pairs, it has a third. All life on earth is based on the combination of four chemicals. Adenine bonds naturally with thymine to create the A-T section of the formula, while guanine … Continue reading

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7 [Embryology] The Proof That Islam Is The Truth [Abdur Raheem Green] – Video

Posted: Published on May 8th, 2014

7 [Embryology] The Proof That Islam Is The Truth [Abdur Raheem Green] PLEASE WATCH SHARE THIS VIDEO. By: SpiritualityTube … Continue reading

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Paris Primeau with Mad Harmoni – DNA Cover by Little Mix – Video

Posted: Published on May 8th, 2014

Paris Primeau with Mad Harmoni - DNA Cover by Little Mix Paris Primeau singing with group Mad Harmoni - DNA doing Cover by Little Mix Mad Harmoni Social Links http://Twitter.com/madharmoni http://facebook.com/madharmoni My Social Media Links: http://ww... By: Paris Primeau … Continue reading

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DNA 7a Grande Grotta Kalymnos #88 – Video

Posted: Published on May 8th, 2014

DNA 7a Grande Grotta Kalymnos #88 Reach your summit whit Lostarrow! COME AND CLIMB AT THE RAW TILL 4 FESTIVAL JULY 1ST - 15TH CHANG MAI THAILAND https://www.facebook.com/groups/rawti... Follow my journey to become the strongest... By: Vertical Addiction … Continue reading

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How Private is Your DNA? – Video

Posted: Published on May 8th, 2014

How Private is Your DNA? Scientists are now able to map our bodies' DNA with increasing ease and decreasing costs. But what is being done with this information and for whose benefit?... By: TheCRGChannel2 … Continue reading

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