Cialis, normally used to treat erectile dysfunction in men, may offer promise for boys with a fatal muscle disorder. In a preliminary study published today in the journal Neurology, the drug appears to improve blood flow to the boys' muscles, just as it boosts blood flow to the penis of men with erectile dysfunction. The drug was given to 10 boys over a short period, so the results are far from conclusive. They do indicate that Cialis deserves more research as a treatment for the boys' disease, known as Duchenne muscular dystrophy. "We had really striking results," said Ronald Victor, a cardiologist at Cedars-Sinai Medical Center in Los Angeles, who led the work. Examining the boys' muscle cells after treatment, he said, "it looked like a complete correction of the blood flow abnormality." In Duchenne muscular dystrophy, boys who are apparently normal until age 4-8, suddenly start to go weak. In their 20s or sometimes earlier, their heart or diaphragm ?? both muscles ?? give out, and they die. The genetic glitch that causes the disease robs the body of its ability to produce a muscle protein called dystrophin, which provides structure to muscles and helps send cellular signals. Without … Continue reading
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