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Stem Cells Used to Regenerate Heart Muscle in Monkeys

Posted: Published on May 2nd, 2014

WEDNESDAY, April 30, 2014 (HealthDay News) -- Scientists who used human embryonic stem cells to regenerate damaged heart muscle in monkeys say this technique could be ready for human clinical trials within four years. If the research proves successful, it could provide a way to restore normal function in failing hearts, according to the researchers. Before this study, it wasn't known if it would be "possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart," team leader Dr. Charles Murry, professor of pathology and bioengineering at the University of Washington in Seattle, said in a university news release. Murry and his colleagues triggered heart attacks in anesthetized macaque monkeys and two weeks later injected 1 billion heart muscle cells derived from human embryonic stem cells into the damaged areas of the heart. That amount of cells was 10 times greater than what the researchers had previously been able to create. The monkeys received immune system-suppressing drugs to prevent rejection of the transplanted human cells. Within a few weeks, the new heart muscle cells matured and began to … Continue reading →

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Stem cell breakthrough in treating heart attacks

Posted: Published on May 2nd, 2014

An implanted graft of cardiac cells derived from human stem cells (green) meshed with a monkey's own heart cells (red). Picture: Murry Lab/University of Washington/PA Stem cell heart repair treatments could be tested on human patients within four years following a ground-breaking study of monkeys. Scientists successfully restored damaged cardiac muscle in macaque monkeys suffering the after-effects of experimentally induced heart attacks, paving the way to clinical trials. Researchers injected 1bn immature heart muscle cells derived from human embryonic stem cells into each animals heart. Over several weeks, the new cells developed, assembled into muscle fibres, and began to beat in correct time. On average, 40% of the damaged heart tissue was regenerated. It is the first time stem cell therapy for damage caused by heart attacks has been shown to work in a primate. Lead scientist Prof Charles Murry, director of the Centre for Cardiovascular Biology at the University of Washington in Seattle, said: Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularise damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart. He expects … Continue reading →

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Sperm precursors made from stem cells of infertile men

Posted: Published on May 2nd, 2014

PUBLIC RELEASE DATE: 1-May-2014 Contact: Mary Beth O'Leary moleary@cell.com 617-397-2802 Cell Press Researchers reporting in the Cell Press journal Cell Reports on May 1st have successfully coaxed stem cells made from the skin cells of infertile men into producing sperm cell precursors. These induced pluripotent stem cells (iPSCs) produced sperm precursors following transplantation into the testes of mice. The findings help to explain a genetic cause of male infertility and offer a window into basic sperm biology. The approach also holds considerable potential for clinical application, the researchers say. "Our results are the first to offer an experimental model to study sperm development," said Renee Reijo Pera of the Institute for Stem Cell Biology & Regenerative Medicine and Montana State University. "Therefore, there is potential for applications to cell-based therapies in the clinic, for example, for the generation of higher quality and numbers of sperm in a dish. "It might even be possible to transplant stem-cell-derived germ cells directly into the testes of men with problems producing sperm," she added. However, getting to that point will require considerable study to ensure the safety and practicality. Infertility affects 10% to 15% of couples. Moreover, as the researchers note, genetic causes of … Continue reading →

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Stem cell therapy | irish stem cells – Video

Posted: Published on May 2nd, 2014

Stem cell therapy | irish stem cells http://www.arthritistreatmentcenter.com So what's going on in Ireland when it comes to arthritis... coming up next... First signs of arthritis cure seen by Irish researchers The first signs... By: Nathan Wei … Continue reading →

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Functional human cartilage grown in lab

Posted: Published on May 2nd, 2014

Home > News > technology-news Washington, May 1 : In a pioneering work, researchers at Columbia Engineering have successfully grown fully functional human cartilage from human stem cells derived from bone marrow tissue. "We have been able to generate fully functional human cartilage from mesenchymal stem cells by mimicking in vitro the developmental process of mesenchymal condensation," explained Gordana Vunjak-Novakovic, the Mikati Foundation professor of biomedical engineering at Columbia Engineering. This could have clinical impact, as this cartilage can be used to repair a cartilage defect, or in combination with bone in a composite graft grown in lab for more complex tissue reconstruction, he informed. The general approach to cartilage tissue engineering has been to place cells into a hydrogel and culture them in the presence of nutrients and growth factors and sometimes also mechanical loading. But using this technique with adult human stem cells has invariably produced mechanically weak cartilage. So Vunjak-Novakovic and her team wondered if a method resembling the normal development of the skeleton could lead to a higher quality of cartilage. They came up with a new approach - by inducing the mesenchymal stem cells to undergo a condensation stage as they do in the body … Continue reading →

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Dunya IVF Announced That Baby Gender Selection Is Becoming Hugely Popular for Couples Willing to Travel to Cyprus for It

Posted: Published on May 2nd, 2014

(PRWEB UK) 1 May 2014 Dunya IVF is focusing on the fact that due to regulatory limitations only a few countries in the world offer this treatment. One of the very few countries in Europe to offer gender selection is Cyprus. Dunya IVF Clinic has been operating since 2005 and have successfully performed thousands of IVF procedures with several hundred of them being for gender selection, according to its logs. As Dunya IVF clinic explains for couples going through this treatment the procedure is relatively simple. They undergo a normal IVF procedure with the exception of only the embryos of the desired gender being transferred to the expecting mother. In order for the gender of the embryo to be known before the transfer, a genetic testing is performed. This involves checking the embryos for the X/Y chromosome. In addition to the X/Y chromosome, usually several other chromosomes are checked during this genetic testing to ensure the embryos are also free from genetic diseases like Downs syndrome and Trisomy. Therefore, couples wishing to do gender selection (PGD - Preimplantation Genetic Diagnosis) also will have the added benefit of knowing that the embryos are free from these genetic diseases. Today, the accuracy … Continue reading →

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A new syndrome caused by mutations in AHDC1

Posted: Published on May 2nd, 2014

PUBLIC RELEASE DATE: 1-May-2014 Contact: Glenna Picton picton@bcm.edu 713-798-7973 Baylor College of Medicine HOUSTON (May 1, 2014) -- A team of researchers led by Baylor College of Medicine have identified the gene underlying a newly recognized genetic syndrome that has symptoms of sleep apnea, delayed speech and hyptonia, or generalized upper body weakness. The study published online today in the American Journal of Human Genetics. The Baylor researchers first studied a patient from Australia with these symptoms who had been seen by many doctors and had multiple diagnostic tests, without any diagnosis. Although there was no family history of the disease, the researchers performed DNA sequence analysis on the patient and her parents to determine if there was an underlying genetic cause for her symptoms. The results showed damaging mutations had newly arisen in five genes in the patient when compared with the parents DNA sequence. One gene was a candidate for causing the disease because similar mutations were never seen in healthy control individuals. "This led us to ask if there were any other undiagnosed disease cases that had similar mutations in this gene," said Dr. Fan Xia, assistant professor of molecular and human genetics and in the Whole … Continue reading →

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Genetics Wildhorse – Video

Posted: Published on May 2nd, 2014

Genetics Wildhorse description. By: Candace McMullan … Continue reading →

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Let’s Play: The Sims 3 Pets – (Part 34) – Equestrian Genetics – Video

Posted: Published on May 2nd, 2014

Let's Play: The Sims 3 Pets - (Part 34) - Equestrian Genetics HIGHLIGHTS: -Julie's midlife crisis ends! (thank god.. -We get lifetime happiness rewards! -Queen gets to level 9 in racing! -Granny learns the handiness ski... By: SoulSimmer … Continue reading →

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Cannabis Genetics & History EXODUS CHEESE grown by Lady Sativa Genetics Amsterdam Weed Review – Video

Posted: Published on May 2nd, 2014

Cannabis Genetics History EXODUS CHEESE grown by Lady Sativa Genetics Amsterdam Weed Review visit http://andrew.pyrah.net for more - COMMENT and LIKE if you enjoyed the video and SUBSCRIBE to see my new videos as they are released - it all helps my ... By: Andrew Pyrah … Continue reading →

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