Heart cells created from human embryonic stem cells successfully restored damaged heart muscles in monkeys. The results of the experiment appear in the April 30 advanced online edition of the journal Nature in a paper titled, "Human embryonic-stem cell derived cardiomyocytes regenerate non-human primate hearts." The findings suggest that the approach should be feasible in humans, the researchers said. "Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart," said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment. A physician/scientist, Murry directs the UW Center for Cardiovascular Biology and is a UW Medicine pathologist. Murry said he expected the approach could be ready for clinical trials in humans within four years. In the study, Murry, along with Dr. Michael Laflamme and other colleagues at the UW Institute for Stem Cell & Regenerative Medicine, experimentally induced controlled myocardial infarctions, a form of heart attack, in anesthetized pigtail macaques. The infarcts were created by blocking the coronary artery of … Continue reading →