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UNC researchers discover ‘master regulator’ role for little-known protein in cancer cells

Posted: Published on April 30th, 2014

PUBLIC RELEASE DATE: 29-Apr-2014 Contact: Mark Derewicz mark.derewicz@unch.unc.edu 919-923-0959 University of North Carolina Health Care CHAPEL HILL, N.C. Researchers in the UNC School of Medicine found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving. The discovery, published in the journal Nature Communications, marks the first time this little-known protein has been characterized in relation to cancer development and tumor growth. "If you knock down DAZAP1, then most of the genes involved in specific cancer cell signaling, cell death, and DNA repair are affected," said Rajarshi Choudhury, PhD, a postdoctoral research associate in the department of pharmacology and first author of the study. "It's a domino effect. DAZAP1 seems to be a sort of master regulator." The protein regulates how genes are spliced together before the genes produce the proteins that are involved in causing cancer cells to grow and divide. When there's a lot of DAZAP1, cancer cells cease proliferating. "We've seen this in six different types of human cancer cell lines in the … Continue reading →

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Cell Analysis Market by Instruments (Flow Cytometer, Microscope, Microfluidics, QPCR), Consumables, Application (Cell …

Posted: Published on April 30th, 2014

Malaysia to open new budget airport in MH370 shadow Sepang (Malaysia) (AFP) - Malaysia this week opens what it calls the world's largest airport built specifically for low-cost airlines, a project driven by budget travel's phenomenal growth but which debuts under the shadow of missing flight MH370. The $1.2 billion facility near the main Kuala Lumpur International Airport (KLIA) was originally targeted to open three years ago but has been hit by repeated delays, amid concerns over safety and subpar construction, even as costs have doubled. But the new KLIA2 budget terminal will begin operations Friday with an initial 56 flights, increasing the load as airlines move full operations over from a nearby existing facility in coming days. Its modern design features soaring ceilings, natural lighting, people-mover belts and improved connectivity with access to an existing express airport train to Kuala Lumpur 50 kilometres (31 miles) away. Read more from the original source: Cell Analysis Market by Instruments (Flow Cytometer, Microscope, Microfluidics, QPCR), Consumables, Application (Cell ... … Continue reading →

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A4M Fellowship in Aesthetic Medicine @ IMA Dubai – Dr. Ayesha Rehman – Video

Posted: Published on April 30th, 2014

A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Ayesha Rehman A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Ayesha Rehman. By: Institute of Medical Aesthetics … Continue reading →

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A4M Fellowship in Aesthetic Medicine @ IMA Dubai – Dr. Jagdeep Gupta – Video

Posted: Published on April 30th, 2014

A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Jagdeep Gupta A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Jagdeep Gupta. By: Institute of Medical Aesthetics … Continue reading →

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A4M Fellowship in Aesthetic Medicine @ IMA Dubai – Dr. Hanadi Abu Yousif – Video

Posted: Published on April 30th, 2014

A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Hanadi Abu Yousif A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Hanadi Abu Yousif. By: Institute of Medical Aesthetics … Continue reading →

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A4M Fellowship in Aesthetic Medicine @ IMA Dubai – Dr. Nathalie Domloj – Video

Posted: Published on April 30th, 2014

A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Nathalie Domloj A4M Fellowship in Aesthetic Medicine @ IMA Dubai - Dr. Nathalie Domloj. By: Institute of Medical Aesthetics … Continue reading →

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Saudi- Conference to shed light on latest stem cell applications

Posted: Published on April 30th, 2014

(MENAFN - Arab News) The king abdullah international medical research center (kaimrc) recently joined a conference on stem cell research and its application science and medicine the saudi press agency reported. the conference which was organized by the health affairs at the national guard unveiled the latest discoveries and findings made by researchers at the stem cell and regenerative medicine unit at kaimrc the agency said. the conference was attended by several experts on stem cell research representing saudi arabia the united states britain france sweden italy australia and new zealand. ahmed al-askar ceo of kaimrc said stem cell research is a broad topic that sheds light on how to best exploit human cells to treat diseases for certain organs such as the liver kidney or nerves. he said the current use of stem cells is centered on plantation for the treatment of certain types of leukemia cancer and genetic diseases. since its inception three years ago the center has transplanted 200 cells following the creation of a program for transplanting stem cells in children and adults he said. saudi arabia has the sole stem cell donation registry in arab countries compared with 60 cells donation registries globally he said. … Continue reading →

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FDA Approves Embryonic Stem Cell Experiments on Humans

Posted: Published on April 30th, 2014

Teratomas - tumors that arise from what are essenitally partially differentiated stem cells As South Dakota considers repealing the state ban on embryonic stem cell research, this issue is receiving more and more attention on a national level. President Obama came to the White House last month carrying the campaign promise that he would reverse President Bushs 2001 ban on taxpayer funding of embryonic stem cell research (except for a few specific lines of embryonic stem cells already harvested). The fact that Obama has not yet done so is a matter of consternation for those eager to destroy innocent human life in the hopes that stem cells derived from them might, maybe, someday cure various diseases in other humans. There may be some eagerness for those tax dollars and research grants, too. Even as some work to put the taxpayers on the hook for this destruction of innocent human life and to lift state bans, adult stem cell research has for a number of years been producing successful treatments for various illnesses and injuries. These includemeningitis-relatedlimb damage, brain injury, stroke, retinaregeneration, heart tissueregeneration,angina,diabetes, bone cancer, nerve regeneration,cerebral palsy,cartilage regeneration, Parkinsons,kidney damage,liver cancer, lupus,multiple sclerosis,and leukemia. Adult stem cell therapy also … Continue reading →

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Stem cell jab is 'five times better than drugs' for treating people with life-threatening heart conditions

Posted: Published on April 30th, 2014

British study involved more than 1,000 sufferers of chronic heart disease Indicated injecting stem cells into heart significantly increase survival rates Those who had the treatment less likely to be readmitted to hospital Patients who had injection also more likely to have improved heart function By Daily Mail Reporter Published: 18:37 EST, 29 April 2014 | Updated: 02:30 EST, 30 April 2014 Stem cells could be five times more effective in treating people with life-threatening heart diseases than conventional drugs. A study involving more than 1,000 sufferers of chronic heart disease indicated that injecting stem cells into the heart can significantly increase survival rates after a year. It found that those who underwent the treatment were less likely to be readmitted to hospital and also had improved heart function. Stem cells could be five times more effective in treating people with life-threatening heart diseases than conventional drugs Stem cell treatment for heart disease is currently limited to specialist research centres, where cells are extracted from a patients own blood or bone marrow and used to repair damaged tissue in the heart and arteries. The Cochrane Heart Review Group looked at data involving 1,255 people from 23 trials, where all patients … Continue reading →

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germing alphakronic genetics and purp widow – Video

Posted: Published on April 30th, 2014

germing alphakronic genetics and purp widow germing alphakronic genetics and purp widow. By: D Stern … Continue reading →

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