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EDITORIAL: London researchers illustrate potential of stem cell therapies

Posted: Published on April 11th, 2014

When researchers and, especially, the general public became aware of the potential medical uses of stem cells the possibilities seemed endless. The National Institutes of Health said this: ... a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities, including Parkinsons disease, amyotrophic lateral sclerosis, spinal cord injury, burns, heart disease, diabetes, and arthritis. Already subscribe to the Evansville Courier & Press or The Gleaner? Unlimited access to CourierPress.com, TheGleaner.com and the Courier & Press smartphone and tablet apps is included with your subscription. All you need to do is ACTIVATE now! Activate Now Want to keep reading? We now offer Premium and Digital Subscriptions. Subscribe now and select how you want to keep up-to-date on local news, reader comments, photos, videos, blogs and more. Subscribe Now 2014 Evansville Courier & Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Read this article: EDITORIAL: London researchers illustrate potential of stem cell therapies … Continue reading →

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Former NIH stem-cell chief joins New York foundation

Posted: Published on April 11th, 2014

Nature News Blog 10 Apr 2014 | 22:47 BST | Posted by Sara Reardon | Category: stem cells Stem-cell biologist Mahendra Rao, who resigned last week as director of the Center for Regenerative Medicine (CRM) at the US National Institutes of Health (NIH), has a new job. On 9 April, he was appointed vice-president for regenerative medicine at the New York Stem Cell Foundation (NYSCF), a non-profit organization that funds embryonic stem-cell research. Rao left the NIH abruptly on 28 March, apparently because of disagreements about the number of clinical trials of stem-cell therapies that the NIHs intramural CRM programme would conduct. The CRM was established in 2010 to shepherd therapies using induced pluripotent stem cells (iPS cells) adult cells that have been reprogrammed to an embryonic state into clinical translation. One of the CRMs potential therapies, which will use iPS cells to treat macular degeneration of the retina, will continue moving towards clinical trials at the NIH, although several others were not funded. NIH officials say that the CRM will not continue in its current direction, but the fate of the centres remaining budget and resources is undecided. Rao says that he wants to move more iPS cell therapies … Continue reading →

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Community helps Gilbert boy with Cerebral Palsy

Posted: Published on April 11th, 2014

GILBERT, AZ - Seven-year-old Andrew Burkhart can now run like other kids his age, due to stem cell treatments and donations from strangers. Kellie Burkhart says her son was diagnosed with Cerebral Palsy when he was 4 years old. Cerebral palsy is a brain and nervous system disorder, which can cause motor disability in a child. He was tongue-tied at birth pretty significantly, said Burkhart. His tongue was connected up front, so that was the first really obvious. Burkhart says Andrew didnt talk until he was 3 years old. He also suffered severe gastrointestinal issues. At 4 years old he weighed 50 pounds and still was in diapers. Traditional methods werent working so Kelli turned to a doctor in California. The doctor said we should do bone marrow from Andrews own hip. So he, the doctor, processed Andrews stem cells and then put it back into him through an IV, said Burkhart. It was like Gods hand touched him and turned on a switch. His GI system was fixed and within a week, he was potty trained within a month, said Burkhart. Insurance companies consider the stem cell therapy out of pocket. Each summer the family spends around $28,000 for … Continue reading →

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Grateful patient donates $6.5 million to Shiley Eye Center

Posted: Published on April 11th, 2014

Doctors perform eye surgery in an operating room at Shiley Eye Center Wednesday. The center recently received a $6.5 million gift to help establish a new stem cell research laboratory. A $6.5 million donation from an unnamed patient will help the Shiley Eye Center at UC San Diego strengthen its focus on stem cells, which hold the promise of repairing damage done by diseases such as glaucoma and macular degeneration. Dr. Robert Weinreb, the centers director and a widely-published glaucoma researcher, said hes conducting a worldwide search for stem cell scientists to come to Shiley, which last year ranked fourth in National Institutes of Health funding among ophthalmology research centers nationwide. Stem cells are known for their ability to transform themselves into nearly any other type of cell in the body, and scientists are exploring ways to use this Rosetta stone of biology to repair damage caused by cancer, diabetes and a range of other diseases. Theres also huge potential for stem cells and the human eye. Were going to use the stem cells to treat retinal diseases including macular degeneration, to rescue the optic nerve in glaucoma, as well as to replace the diseased layers of the cornea in … Continue reading →

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Gene, stem cell therapies trials underway for Parkinson's, but not in Mumbai

Posted: Published on April 11th, 2014

illustration by: Ravi Jadhav Stem cells and gene hold promising treatment options for Parkinson's Disease, say doctors across the globe, including those in Mumbai. Eleven trials to test stem cell and gene therapies for treating the disease are currently underway. In Mumbai, however, only two out of these 11 trials were being done resource constraints led to one being canned and regulatory hurdles have put the other one on hold. Currently, neuro-augmentative therapies, such as usage of drugs or deep brain stimulation (DBS), are being used to treat Parkinson's Disease. "The future holds hope for neuro-restorative therapies like that of stem cells or gene infusion. Stem cells are the very primary kind of cells which can take on the function of any body part's cells after their infusion with that body part. It (the treatment) involves restoration of brain function to normal. In the next five to seven years, this may pave the way for the future," said Dr Paresh Doshi, neurologist at Jaslok Hospital on Peddar Road. Doshi said trial of Duodopa therapy, which involves infusion of an active ingredient gel called Levodopa in the intestines, has been kept on hold. Jaslok Hospital was the only centre in the … Continue reading →

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Cell Therapy – Technologies, Markets and Companies

Posted: Published on April 11th, 2014

DUBLIN, April 7, 2014 /PRNewswire/ -- Research and Markets(http://www.researchandmarkets.com/research/228q6n/cell_therapy) has announced the addition of a new report"Cell Therapy - Technologies, Markets and Companies"to their offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice. Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation. Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. … Continue reading →

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New cell models for tracking body clock gene function will help find novel meds

Posted: Published on April 11th, 2014

PUBLIC RELEASE DATE: 10-Apr-2014 Contact: Karen Kreeger karen.kreeger@uphs.upenn.edu 215-349-5658 University of Pennsylvania School of Medicine PHILADELPHIA The consequences of modern life -- shift work, cell phone addiction, and travel across time zones -- all disturb internal clocks. These are found in the brain where they regulate sleep and throughout the body where they regulate physiology and metabolism. Disrupting the clocks is called circadian misalignment, which has been linked to metabolic problems, even in healthy volunteers. Researchers from the Perelman School of Medicine at the University of Pennsylvania and the University of Memphis describe in PLOS Genetics the development of new cell models that track and report clock gene function. These engineered cells can be used with inexpensive, off-the-shelf recording devices, making them suitable for small basic labs to large-scale pharmaceutical firms to screen candidate small molecules to help the body's clock function normally. The team started with liver cells and fat cells because they govern the body's energy processing and storing system and genetically engineered them to flash light with a daily rhythm much like an alarm clock. They validated the cell models and showed that changing clock gene function in these cells is similar to what happens in mice … Continue reading →

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Bogalusa firefighters hope to fill boots for MDA

Posted: Published on April 11th, 2014

Firefighters MDA DAILY NEWS PHOTO/Marcelle Hanemann Local firefighters will ask passing motorists in Bogalusa to help Fill the Boot for the Muscular Dystrophy Association every Saturday this month starting tomorrow. The firemen will be on the street at Avenue B and Willis Avenue for about an hour and a half starting at 9 a.m. Union President Duane Fuller said every penny collected goes to the MDA. Shown are, Firefighter Dustin Knight, left, and Fuller. Posted: Thursday, April 10, 2014 11:45 pm Bogalusa firefighters hope to fill boots for MDA BY MARCELLE HANEMANN The Daily News The Daily News | Firefighters will be out on the streets of Bogalusa tomorrow and every remaining Saturday morning through April giving passing motorists the chance to help Fill the Boot for the Muscular Dystrophy Association. Local Union President Duane Fuller said this is the 60th year the International Association of Fire Fighters has partnered with the MDA to raise funds to fight the neuromuscular disease and to provide treatment and support to affected individuals and their families. The support even includes sending kids to camp, he said. Last year, in one day, we raised right at $1,300, Fuller said. This year were doing three … Continue reading →

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Stroke victims forced to pay for rehab as services absent

Posted: Published on April 11th, 2014

David Bowe from Portlaoise who suffered a stroke at 22. Picture: Mark Stedman Stroke victims are being forced to pay privately for vital rehabilitation such as physiotherapy and speech and language therapy because services in the community are so poor. The deficits in community care for sufferers of stroke, highlighted in a National Stroke Survivors Survey, found more than one-third are forced to fork out for rehabilitation once they leave hospital. In addition, almost nine out of 10 are getting no psychological service and a third have no access to physiotherapy, according to the research carried out by the Royal College of Surgeons in Ireland (RCSI) and the Irish Heart Foundation (IHF). The survey findings, presented yesterday on day one of the IHFs two-day National Stroke Conference, outlined how half of stroke survivors have no access to speech and language therapy or occupational therapy in the community. One stroke survivor, musician Dave Bowe, 27, told the conference that he received just 15 minutes of counselling despite the huge psychological impact of suffering a stroke at the age of 22. I had a brief counselling session and that was it. I couldnt get any more. Luckily, I was able to pay … Continue reading →

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Even A Very Weak Signal From The Brain Might Help Paraplegics

Posted: Published on April 11th, 2014

A report that four young men who are paralyzed below the waist were able to move toes, ankles or knees when their lower spine was electrically stimulated was hailed as a breakthrough. But it's hard not to be skeptical about anything labeled a medical breakthrough these days, and that's especially true when it comes to spinal cord regeneration, which has seen more than its share of hype. For the quarter of a million people with spinal cord injuries, dashed hopes can be devastating. A treatment or cure for spinal cord injury remains elusive, but the study by researchers at the University of Louisville appears to add important information: Even a very weak signal from the brain can trigger movement. To figure out what this means, we talked it over with John Donoghue, director of the Brown Institute for Brain Science and leader of the BrainGate II project, which in 2012 made it possible for two people immobilized by strokes to control a robotic arm with their thoughts. He wasn't involved in the Louisville research. The conversation has been edited for length and clarity. When a spinal cord is severed, that causes paralysis. There have been decades of efforts to bridge … Continue reading →

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