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Research Study Takes Deeper Look at the Role of Gut Microbes in the Immune System

Posted: Published on March 25th, 2014

Contact Information Available for logged-in reporters only Newswise LOS ANGELES (March 24, 2014) New research suggests that gut microorganisms do not merely influence immune cell function, but also support the production of immune cells that form the first line of defense against infection. By understanding the mechanisms responsible for maintaining and replacing immune cells, researchers hope to one day develop targeted therapies to support and boost immune function in humans. Study investigators from the Regenerative Medicine Institute at Cedars-Sinai collaborated with the Mount Sinai School of Medicine and lead institution the California Institute of Technology. Previous research studies have evaluated the influence of gut microbes on the function of immune cells, but little had been known about their influence on the production of immune cells, a process known as hematopoiesis. In this study, published in the journal Cell Host & Microbe, investigators found that mice lacking gut microbes were defective in immune cell production. Immune cell populations have to be maintained and replaced to ensure enough immune cells are available to fight infection. Consequently, the investigators noted that mice lacking gut microbes were more susceptible to bacterial infections. This work provides important clues about the role of gut microbes in … Continue reading

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Heart Stem cell therapy – Video

Posted: Published on March 24th, 2014

Heart Stem cell therapy Clara answers some questions regarding the stem-cell therapy she received for congenital heart disease. For more info visit: http://www.stemaid.com. By: stemaid … Continue reading

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New Mesenchymal Stem Cell Population from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and …

Posted: Published on March 24th, 2014

There are currently over 300 clinical trials evaluating MSC therapeutic utility in a variety of diseases. Unlike other types of cellular therapies, MSCs can be used in allogeneic settings without immunosuppressive therapy due to the cells ability to evade immune detection. MSCs home to injured tissue and provide therapeutic support through a multifaceted mechanism. They secrete a dynamic assortment of bioactive cytokines, trophic factors, and anti-inflammatory molecules in response to environmental cues. The traditional sources of MSCs are from adult tissues and have limited expansion capacity and so must be constantly replenished from more donors, and screened for pathogens. Moreover, there is an appreciable loss of potency upon propagation of adult MSCs in culture, which along with inconsistent quality of current MSC sources, limits the scalability of their use in therapy. We believe our new method can overcome these limitations as we have taken advantage of a versatile precursor cell called the hemangioblast. hESC-derived hemangioblasts replace the need for donors, and our pre-clinical studies have demonstrated these hESC-MSCs have the capacity to respond to environmental cues, influence immune cell function, and exert therapeutic effects to reduce clinical symptoms in two different autoimmune disease models. This population of MSCs may have … Continue reading

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GDNF transfection promotes neuronal differentiation of bone marrow mesenchymal stem cells

Posted: Published on March 24th, 2014

PUBLIC RELEASE DATE: 21-Mar-2014 Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research Studies have shown that the differentiation rate of grafted bone marrow mesenchymal stem cells into mature neuron-like cells is very low. Therefore, it is very important to establish an effcient and stable induction protocol to promote the differentiation of bone marrow mesenchymal stem cells into neuron-like cells in vitro and elucidate the mechanisms underlying differentiation for the treatment of central nervous system diseases. Jie Du and colleagues from Sichuan University in China found that glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells have a higher rate of induction into neuron-like cells, and this enhanced differentiation into neuron-like cells may be associated with up-regulated expression of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43. The researchers provide experimental support for the therapeutic use of glial cell line-derived neurotrophic factor gene-modified bone marrow mesenchymal stem cells in transplantation strategies for central nervous system diseases. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 1, 2014). ### Article: " Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation," by Jie Du1, 2, Xiaoqing Gao3, Li Deng3, Nengbin Chang2, Huailin … Continue reading

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Groundbreaking Treatment For Muscular Dystrophy Held Up By FDA, Family Says

Posted: Published on March 24th, 2014

Get Breaking News First Receive News, Politics, and Entertainment Headlines Each Morning. SACRAMENTO (CBS13) A family is fighting for the life of their young son. He had been undergoing treatment, getting an experimental drug through a study at the UC Davis Medical Center. But that study has ended, and now they fear that he could lose his battle. Ryan Dunne goes through the motions other 9-year-olds take for granted. He struggles, his muscles failing him more and more. He has Duchenne Muscular Dystrophy; his muscles are wasting away. Things are tough, he has a hard time getting up and down stairs, said Ryans mother, Jennifer Dunne. As his muscles give out, its a near certainty the disease will rob Ryan of his mobility, and his life before hes 30. Its a progressive disease. Every day he gets weaker, Jennifer said. There was a time when the downward spiral slowed: When Ryans family was flying weekly from Colorado to Sacramento, taking part in a clinical trial with the UC Davis Health System. DMD is actually is the most common form of muscular dystrophy in children. Its actually due to absence of one of the most common and ubiquitous proteins in the … Continue reading

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The FSH Society Issues Six Research Grants to Propel Understanding and Treatment of FSHD

Posted: Published on March 24th, 2014

Lexington, MA (PRWEB) March 24, 2014 Today, the FSH Society, a Massachusetts based non-profit that is a world leader in combating facioscapulohumeral dystrophy (FSHD), announced that it has awarded six grants totaling more $609,525 to new research projects. Through these studies, the FSH Societys fellowship program aims to gain insights and achieve significant milestones into the research of FSHD, one of the most prevalent types of muscular dystrophy. A degenerative muscle disease, FSHD causes progressive weakness, usually starting with the face, shoulder and arms, but can affect almost any skeletal muscle. FSHD affects approximately 500,000 people worldwide and between one and two percent of the population carries a genetic trait that places future generations at risk of the disease. Currently, there is no cure or effective treatment. Research grants most recently awarded by the FSH Society include: 1.Investigating effects of PARP1 inhibitors in DUX4 expression ($89,267) Yi-Wen Chen, D.V.M., Ph.D. George Washington University and Childrens National Medical Center (Washington, D.C.) A mysterious protein called DUX4 is believed to cause FSHD. The findings of the study will provide insights of the involvement of PARP1, a promoter of the DUX4 gene, in FSHD, and will have a direct impact on developing therapeutics … Continue reading

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Raymond Romanczyk, From Binghamton's Institute for Child Development, Is a World Renowned Expert in the Areas of …

Posted: Published on March 24th, 2014

Contact Information Available for logged-in reporters only Raymond Romanczyk Executive Director of the Binghamton University Institute for Child Development & Distinguished Service Professor of Psychology Autism spectrum disorders; Attention deficit and learning disabilities; Applied behavior analysis; Behavior Therapy; Techonology use in human services; Assessment and treatment of childhood disorders.My laboratory is primarily focused upon research concerning the etiology, assessment, and treatment of childhood disorders: in particular, autism spectrum disorders, developmental, attention, and learning disorders, as well as family variables and issues. The Institute for Child Development maintains a state certified, full-day school serving children 12 months to 12 years of age), as well as child clinics (The Children's Units) that provide "in-house" opportunities for clinical training and research. A large, full-time professional staff is employed by the Units, composed of individuals in clinical psychology, school psychology, neuropsychology, special education and speech pathology. The laboratory has extensive state of the art research equipment. Research Interests: Autism Spectrum Disorders, Attention Deficit and Learning Disabilities, Applied Behavior Analysis, Behavior Therapy, Technology Application to Human Services, Large Scale Service Delivery Systems Link: Raymond Romanczyk, From Binghamton's Institute for Child Development, Is a World Renowned Expert in the Areas of ... … Continue reading

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Stroke Symptoms

Posted: Published on March 24th, 2014

While the long-term consequences of a stroke can vary dramatically, early treatment provides the best chance for a complete recovery. So it is imperative for everyone to know early warning signs of a stroke. Millions of people suffer a stroke each year and it is a leading cause of death. Knowing what to look for should you or a loved one develop stroke symptoms can be life-saving. The American Stroke Association has an easy-to-understand acronym to aid in early recognition of a stroke, called F.A.S.T. Face - A common stroke sign is an asymmetric appearance of the face. For instance, there may be drooping of one side of the mouth, one eyelid may appear droopy, or the normal facial wrinkles may appear to be smoother than usual. Arm - A person experiencing a stroke may notice weakness of an arm. Sometimes both arms may be affected. An easy test for weakness is to have the person hold out her arms. If she cannot hold one up against gravity, and it drifts downward, that may be a sign of a stroke. Likewise, if the ability to lift a coffee cup or other items is impaired, this may also indicate the presence … Continue reading

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Picture Perfect Diagnosis

Posted: Published on March 24th, 2014

Contact Information Available for logged-in reporters only Newswise When the clock starts ticking after the onset of stroke symptoms, access to a neurologist is crucial. Quickly diagnosing a stroke allows for the administration of lifesaving tPA (tissue plasminogen activator) in patients who quality for this treatment. tPA is a clot busting drug that can restore blood flow to the brain; if given to the patient within three to four hours of the onset of a stroke, tPA can improve the chances of recovering from a stroke. Baylor Health Care System is bringing advanced neurologic stroke expertise to its community-based medical centers via a portable robot communication system or telemedicine. This telemedicine system allows a neurologist to look at, talk to and examine the patient, and help make treatment decisions, said Dion Graybeal, M.D., medical director for Baylor Health Care Systems hub-and- spoke stroke program. Neuro-hospitalists based at Baylor University Medical Center in Dallas use IPads or laptop computers to connect with other Baylor medical centers whenever a call comes from their emergency departments. Currently Baylor Medical Centers at Irving, Garland, Waxahachie, Baylor Regional Medical Center at Plano, and Baylor All Saints Medical Center at Fort Worth utilize the hub-and-spoke stroke … Continue reading

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It's My Job: Stroke care moves forward

Posted: Published on March 24th, 2014

It's My Job Dr. M. Ziad Darkhabani, right, works with Nancy Schulte, an interventional radiology technician to position an X-ray imaging arm to help guide him in threading a catheter into a patients brain to remove a blood clot. Scott Thuen / Special to The Forum FARGO It was not long ago that treatment for a stroke focused on rehabilitation. Because of a lack of blood flow to the brain, most patients who survived suffered brain damage and other disabilities. They often faced months of rehabilitation or life in a care facility. Today, if a stroke is diagnosed early and treatment applied, the survival rate and outcome can be better. Dr. Ziad Darkhabani is a stroke and interventional neurologist at Essentia Health. He specializes in using catheters to remove blood clots and repair aneurysms in the brain. Q. What do you do? Interventional neurology means we treat the vessels of the head and neck using a catheter technique. A catheter is a plastic hose or tube made specially to go inside the vessel. Most of the time we go through the femoral artery, which is a vessel in the leg. There are two aspects of the job. The first is … Continue reading

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