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Jim Stowers Jr., 90, gave fortune to fight disease

Posted: Published on March 19th, 2014

1:00 AM The Kansas City man funded stem cell research. The Associated Press KANSAS CITY, Mo. Jim Stowers Jr., the billionaire founder of one of the nations leading investment management firms who gave away most of his fortune to fight disease, has died. He was 90. The Kansas City, Mo., philanthropist, whose tenacity in business was just as fierce as in his fight for stem-cell research, died Monday after a period of declining health, according to a news release issued by his namesake research firm and the investment firm he founded, American Century Investments. Stowers was a struggling mutual fund salesman in 1958 when he founded Twentieth Century Investors Inc. with only two mutual funds and $107,000 in assets. That company grew into American Century Investments, one of the nations leading investment management firms that, as of 2013, was managing about $141 billion. In 2000, Stowers and his wife, Virginia, who both successfully fought cancer, promised more than $1 billion of their fortune to create the Stowers Institute for Medical Research in Kansas City. Stowers and his wife said they wanted the institute to focus on basic research into how genes work, to determine ways to alter genes to fight … Continue reading →

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Genetic, Non-Invasive Test Could Improve Colon Cancer Screening

Posted: Published on March 19th, 2014

Contact Information Available for logged-in reporters only Newswise A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member. The large-scale, cross-sectional study was published online today in The New England Journal of Medicine. The study compared two different types of tests used for screening colorectal cancer: a non-invasive, multitarget stool test that includes DNA markers related to colon cancer along with a test that detects stool blood, versus a commercial fecal immunochemical test (FIT). While the FIT test detects hidden blood in the stool, a potential signal for cancer, the multitarget test also includes genetic mutations in the stool that are related to cancer. In the study of nearly 10,000 participants, the DNA test detected 92 percent of colon cancer, significantly more cancers compared to the 72 percent for the FIT test in asymptomatic participants at average risk for colorectal cancer. The results from this study could impact screening rates, which remain frustratingly low in the U.S. despite the … Continue reading →

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Genetic test could improve colon cancer screening

Posted: Published on March 19th, 2014

PUBLIC RELEASE DATE: 19-Mar-2014 Contact: Katy Jones katy_jones@unc.edu 919-962-3405 University of North Carolina Health Care A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member. The large-scale, cross-sectional study was published online today in The New England Journal of Medicine. The study compared two different types of tests used for screening colorectal cancer: a non-invasive, multitarget stool test that includes DNA markers related to colon cancer along with a test that detects stool blood, versus a commercial fecal immunochemical test (FIT). While the FIT test detects hidden blood in the stool, a potential signal for cancer, the multitarget test also includes genetic mutations in the stool that are related to cancer. In the study of nearly 10,000 participants, the DNA test detected 92 percent of colon cancer, significantly more cancers compared to the 72 percent for the FIT test in asymptomatic participants at average risk for colorectal cancer. The results from this study could impact screening rates, which remain … Continue reading →

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Miscarriage Clues Identified in New DNA Test According to Researchers at Montefiore and Einstein

Posted: Published on March 19th, 2014

Contact Information Available for logged-in reporters only Newswise NEW YORK (March 19, 2014) New research shows an alternative DNA test offers clinically relevant genetic information to identify why a miscarriage may have occurred years earlier. Researchers were able to identify chromosomal variants and abnormalities in nearly 50 percent of the samples. This first-of-its-kind study was conducted by researchers from Montefiore Medical Center and the Albert Einstein College of Medicine of Yeshiva University. The results were published in the March issue of Reproductive Biology and Endocrinology. The technique used in this study, called rescue karyotyping, allows physicians to obtain important genetic information from tissue that had not been tested at the time of the miscarriage. As part of standard hospital protocol, tissue from miscarriages is embedded in paraffin for archival use and the karyotyping test is performed on DNA extracted from this tissue. In this retrospective study of 20 samples from 17 women, genetic testing was successfully performed on 16 samples that had been archived for as long as four years. Of those samples, eight showed chromosomal variants and abnormalities. This is an important alternative when conventional karyotyping is not available or cannot be used for a specific sample. Given the … Continue reading →

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Stem cell transplant helps boy grow past rare disease

Posted: Published on March 19th, 2014

By Amber South asouth@publicopinionnews.com @AESouthPO on Twitter MERCERSBURG >> Two years after a stem cell transplant, Chevy Hockenberry is growing in mind and body toward the 4-year-old that he is. He has started a preschool program, and is improving his speech and getting physically stronger. "He's just very much like a normal boy now," said his mom, Melissa Johnson, Fayetteville. His dad is Lance Hockenberry. But Chevy continues to wear hearing aids and glasses, and still has some physical issues with his bones to contend with as he continues his journey living with Hurlers syndrome. Public Opinion last talked to Johnson in March 2012, about a week before the stem cell transplant surgery to prevent the disease from gaining more ground inside Chevy's little body. Doctors diagnosed Chevy with Hurlers syndrome in January 2012. The rare, inherited disease prevents the body from producing an enzyme that helps break down and process long chains of sugar molecules, according to the University of Maryland Medical Center's website. Without the enzyme, the sugar molecules can build up and damage organs. Chevy stayed at Milton S. Hershey Medical Center for six months after his surgery. The results of the surgery were not immediately great. … Continue reading →

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Kuwait – Conference on leukemia, stem cell transplant kicks off

Posted: Published on March 19th, 2014

MENAFN - Arab Times - 18/03/2014 On his part, Dr. Salem Al- Shemmeri, head of chemotherapy division of Sheikha Badriya Al- Ahmad Al-Jaber Al-Sabah Center for Oncology and Stem Cell Transfusion, said the conference will debate several issues related to leukemia including the lymph node tumors and the latest methods of detection and medication. "The Kuwaiti experts will present to their peers the positive results of the tests they have made in the field of marrow transplant," Dr. Al- Shemmeri, chairman of the conference and head of the Lymphoma unit at the center, added. The conference features a number of workshops and discussions on a number of cases at Sheikha Badriya Center. Meanwhile, Minister of Health Dr. Ali Al-Obaidi Saturday welcomed the "important" decisions of the Arab Health Ministers during their recent meeting in Cairo, Egypt. Al-Obaidi, in a press statement following his return from Cairo where he took part in meetings of the health ministers' council and the Executive Office of the council, described the discussions as objective and constructive. He said his Arab counterparts were eager to develop common Arab action in health and humanitarian fields. Al-Obaidi said the Arab health ministers approved two Kuwaiti proposals, the establishment … Continue reading →

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Korea seeking to boost domestic demand as new driver of economic growth – Video

Posted: Published on March 19th, 2014

Korea seeking to boost domestic demand as new driver of economic growth Exports have long been credited for Korea's rise to the world's 12th largest economy. But the trickle-down effects from the nation's export industries have d... By: ARIRANG NEWS … Continue reading →

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Autism – Video

Posted: Published on March 19th, 2014

Autism By: Stem Cell Therapy Center EMCELL … Continue reading →

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DIY Finger Prick Yields Ample Stem Cells for Banking

Posted: Published on March 19th, 2014

Durham, NC (PRWEB) March 19, 2014 In a study just published in STEM CELLS Translational Medicine, a group of researchers have discovered what appears to be an easy way to collect large quantities of viable stem cells that can be banked for future regenerative medicine purposes all from the simple prick of a finger. We show that a single drop of blood from a finger-prick sample is sufficient for performing cellular reprogramming, DNA sequencing and blood typing in parallel. Our strategy has the potential of facilitating the development of large-scale human iPSC banking worldwide, said Jonathan Yuin-Han Loh, Ph.D., of the Agency for Science, Technology and Research (A*STAR) in Singapore. He is principal investigator on the study that also included scientists from other Singapore facilities as well as those in the United States and Great Britain. The medical world in general is excited about the potential of induced pluripotent stem cells (iPSCs) for studying diseases and for therapeutic regenerative medicine. Stem cells harvested from bone marrow and cord blood are highly amenable to reprogramming. Some methods can result in negative side effects, and then you have bone-marrow harvesting, which is invasive, while cord blood is limited to individuals who have … Continue reading →

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Effect of receptor activity-modifying protein-1 on vascular smooth muscle cells

Posted: Published on March 19th, 2014

PUBLIC RELEASE DATE: 18-Mar-2014 Contact: Bei Shi shi_bei2147@126.com Society for Experimental Biology and Medicine Bei Shi, Xianping Long, Ranzun Zhao, Zhijiang Liu, Dongmei Wang and Guanxue Xu, researchers at the First Affiliated Hospital of Zunyi Medical College within the Guizhou Province of China, have reported an approach for improving the use of stem cells for improvement of infarcted heart function and damage to the arteries in the March 2013 issue of Experimental Biology and Medicine. They have discovered that mesenchymal stem cells (MSCs) transfected with a recombinant adenovirus containing the human receptor activity-modifying protein 1 (hRAMP1) gene (EGFP-hRAMP1-MSCs) when transplanted into rabbit models for both Myocardial infarction (MI) and carotid artery injury inhibit vascular smooth muscle cell (VSMC) proliferation within the neointima, and greatly improved both infarcted heart function and endothelial recovery from artery injury more efficiently than the control EGFP-MSCs. MSCs have good applicability for cell transplantation because they possess self-renewal and multiple differentiation potential. With addition of either environmental or chemical substances, MSCs can differentiate into a variety of cell types. Numerous animal experiments and small clinical trials have shown that MSC transplantation can promote the formation of new blood vessels and reduce myocardial infarct size, and diminish … Continue reading →

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