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New cell line should accelerate embryonic stem cell research

Posted: Published on March 15th, 2014

Mar 14, 2014 by Michael Mccarthy Dr. Carol Ware at work in her laboratory at the Institute for Stem Cell and Regenerative Medicine. Credit: Bryan Donohue Researchers at the University of Washington have successfully created a line of human embryonic stem cells that have the ability to develop into a far broader range of tissues than most existing cell lines. "These cells will allow us to gain a much greater understanding of normal embryonic development and have the real potential for use in developing ways to grow new tissues and organs for transplantation," said Carol Ware, a professor in the UW Department of Comparative Medicine and lead author of a paper describing the new cell line appearing in the March 10 issue of the journal Proceedings of the National Academy of Sciences. The cells, called nave embryonic stem cells, normally appear at the earliest stages of embryonic development and so retain the ability to differentiate in all the different types of cells of the human bodya capacity called pluripotency. Researchers had been able to develop naive cells using mouse embryonic stem cells but to create naive human embryonic stem cells has required inserting a set of genes that force the … Continue reading →

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Major stem cell study debunked on scientific social network

Posted: Published on March 15th, 2014

ResearchGate has found itself at the centre of an international debunking of a Japanese paper that claimed to have found a simple way to generate pluripotent stem cells. The social network for scientists launched in 2008 as a push back against traditional academia and the peer review process. It has now launched Open Review as part of that platform, a system that lets users "publish an open and transparent review of any paper that you have read, worked with, or cited" with the central question always being "is this research reproducible?" Professor Kenneth Ka Ho Lee, chief of stem cell research at the Chinese University of Hong Kong, found the answer was no. "We even repeated it three times -- we're quite confident it doesn't work," Lee told Wired.co.uk. "If we had only repeated it once it would not have been fair on the author." The papers in question were published in Nature and experiments were carried out at the Riken Institute in Japan. It is lead author, 30-year-old Haruko Obokata, who has been in the firing line. The papers describe a technique whereby adult mouse blood cells are transformed into pluripotent stem cells after being submerged in an acid … Continue reading →

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Environmental factors linked to autism, intellectual disability

Posted: Published on March 15th, 2014

Home > News > health-news Washington, March 14 : Scientists have linked autism and intellectual disability in newborn males with genetic changes that could result from harmful environmental factors, a study said. An analysis of 100 million US medical records said that autism and intellectual disability rates are correlated at the county level with incidence of genital malformations in newborn males, an indicator of possible congenital exposure to harmful environmental factors such as pesticides. Autism rates - after adjustment for gender, ethnic, socioeconomic and geopolitical factors - jump by 283 percent for every one percent increase in frequency of malformations in a county. The intellectual disability rates increase 94 percent. Slight increases in autism and intellectual disability rates are also seen in wealthier and more urban counties. The study, published by scientists from the University of Chicago March 13 in PLOS Computational Biology, confirmed the dramatic effect of diagnostic standards, reported Science Daily. Incidence rates for autism and intellectual disability on a per-person basis decrease by roughly 99 percent in states with stronger regulations on diagnosis of these disorders. "Autism appears to be strongly correlated with rate of congenital malformations of the genitals in males across the country," said study … Continue reading →

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Mesenchymal Stem Cells – Stem Cell Treatment

Posted: Published on March 14th, 2014

Mesenchymal stem cells are those stem cells, in adult tissue, that form a variety of different cell types but are not haematopoietic (blood-forming) stem cells. These non-blood somatic (adult) stem cells are found in the bone marrow, in dental pulp, in skin, and adipose tissue, and are multipotent. Initially thought quite rare in the adult body, these mesenchymal stem cells have now been located in so-called stem cell niches and offer an exciting opportunity for stem cell researchers to investigate their abilities to differentiate into different cell types. The derivation of the term mesenchymal is the mesoderm layer of the embryo itself which differentiates into haematopoietic (blood- and immune-forming) stem cells and mesenchymal stem cells. The mesenchymal stem cells of the mesoderm, in the center of the inner cell mass of the blastocyst, are those which go on to form the internal organs like the liver, and kidneys, along with muscle, connective tissue, and bone. Mesenchymal stem cells do not form blood cells or immune system cells however, despite originating from the same layer of the embryo as the haematopoietic stem cells. The term mesenchymal stem cells is regarded by some as inaccurate and the description of these cells as … Continue reading →

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‘Velcro protein’ found to play surprising role in cell migration

Posted: Published on March 14th, 2014

Mar 13, 2014 Normal epithelial cells (red) in this fragment of a mouse mammary duct form branched structures. However, cells that turn on the gene Twist1 (green) detach from neighboring cells and migrate into the surrounding environment. Credit: Eliah Shamir Studying epithelial cells, the cell type that most commonly turns cancerous, Johns Hopkins researchers have identified a protein that causes cells to release from their neighbors and migrate away from healthy mammary, or breast, tissue in mice. They also found that deletion of a cellular "Velcro protein" does not cause the single-celled migration expected. Their results, they say, help clarify the molecular changes required for cancer cells to metastasize. Because epithelial cells give rise to 85 percent of all cancers, the work may have implications outside of breast cancer. A summary of the results was published online on March 3 in The Journal of Cell Biology. Epithelial cells line the inside and outside of organs throughout the body. The team focused their work on mammary epithelial cells, which form the ducts that carry milk within the breast. "Tumor cells have to break their connections to other epithelial cells in order to leave the breast and build metastases in other parts … Continue reading →

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'Landmark' stem cell study discredited

Posted: Published on March 14th, 2014

A Japanese research institute says a study that promised a revolutionary way to create stem cells should be quashed after claims its data was faulty, dealing a huge blow to what was touted as a game-changing discovery. Riken institute head, Ryoji Noyori, who jointly won the Nobel Prize for chemistry in 2001, also heaped criticism on lead researcher Haruko Obokata for her 'sloppiness' and warned the controversy could shake the public's faith in research. The findings, published by 30-year-old Obokata along with other Japanese researchers and a US-based scientist in the January edition of British journal 'Nature', outlined a relatively simple way to grow transplant tissue in the lab. But it faced hard questions as the respected institute, which sponsored the study, launched an inquiry last month over the credibility of its data used in the explosive findings. Among key concerns was that researchers used erroneous images - crucial to supporting the study - which resembled those used in Obokata's doctoral dissertation in 2011. 'I apologise that the papers which Riken researchers recently announced in Nature caused an incident that could hurt the credibility of the scientific community,' Noyori told a press briefing. 'This immature researcher handled and collected enormous … Continue reading →

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Services at the Institute for Aesthetic Surgery and …

Posted: Published on March 14th, 2014

To contact the Institute of Aesthetic Surgery & Medicine please call 914.242.7622 The Institute of Aesthetic Surgery and Medicine at Northern Westchester Hospital is committed to providing the highest quality care for patients who are undergoing aesthetic, reconstructive, and breast surgical procedures. Patients will benefit from the expertise of a highly trained team of professionals and physicians, with the support and safety of having procedures performed in a hospital-based setting. We find our easy access to all of the patient centered services provided at Northern Westchester Hospital is particularly helpful to our body-contouring patients who can benefit from a short hospital stay after surgery. The Institute of Aesthetic Surgery & Medicine is the onlyhospital-basedcosmetic surgery center in the region. In our Aesthetic Oncology Division we offer reconstructive surgery after both lumpectomy and mastectomy, including both skin-sparing and nipple-sparing mastectomies where appropriate. Our reconstructive surgeons use the latest technologies of allograft surgery, SPY technology to measure blood flow, and microsurgical reconstruction including DIEP flaps and PAP flaps. All surgeries benefit from the combined environment of a dedicated staff and facility located within and part of an award winning hospital. Our specialists include plastic and reconstructive surgeons, facial plastic surgeons, oculoplastic surgeons, … Continue reading →

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Stem cell experiments in genetic blood diseases Vector

Posted: Published on March 14th, 2014

The green tips of these chromosomes are telomeres, whose length is a measure of cellular "aging" and determines how many times a cell can divide. In a roomful of kids cancer specialists, like those listening to the keynote speech byGeorge Daley, closinganinternational pediatric oncology meeting in Boston, the Myc gene is better known as a mutated weapon of mass destruction. But this driver of cancer growth is also part of a four-gene cocktail that can reprogram an adult skin cell back into an embryonic-like stem cell that holds great therapeutic potential. Daleys team was among the first to report the creation of induced pluripotent stem cells (iPS cells) in human cells. All it takes is a skin biopsy or a simple blood draw to begin to realize the full potential for any patient, Daley said. Bone marrow transplants from donors already save the lives of some kids with cancer. But Daley sees a future where genetic diseases can be cured by creating iPS cells from a childs own diseased cells, rendering them disease-free through genetic intervention, then growing them into healthy tissue that wont be rejected by the patients immune system. The goal is to create customized patient-specific stem cells, … Continue reading →

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FDA's Regulation of Regenerative Medicine including Stem Cell Treatments, Tissue Engineering, Etc.

Posted: Published on March 14th, 2014

Course Description: Regenerative medicine focuses on harnessing the power of ones own stem cells and regenerative capabilities to restore function to damaged cells, tissues and organs. In April 2006, the U.S. Food and Drug Administrations (FDA) implemented regulations governing the use of human cells, tissues, and cellular and tissue-based products (HCT/Ps) in humans including bone, ligament, skin, dura mater, stem cells, cartilage cells, and various other cellular and tissue-based products. Currently, there is an ongoing debate in the industry on how such therapies should be regulated by FDA or under the practice of medicine, under federal law or state law, and as drugs or simply biologics. This 2-day interactive seminar on FDA regulations of regenerative medicine will cover: -How FDA is currently regulating regenerative therapies and products intended for both human and veterinary use. -The distinction being made between human regenerative products and their regulation as drugs, biologics, devices, and combination products. -The New Drug Application (NDA) and the Biologic License Application (BLA) review and approval processes including a discussion of available options, application components, relevant meetings, timing, costs and approval requirements. -The option for obtaining designation and approval as Orphan Drug Product. -Designing and conducting appropriate clinical trials to … Continue reading →

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Dr. Jeffrey Adler Presents on Use of Stem Cell Therapy at Graham International Implant Symposium

Posted: Published on March 14th, 2014

St. Petersburg, Floriday (PRWEB) March 13, 2014 Dr. Jeffrey Adler of Adler Footcare New York is presenting at the 7th Annual Graham International Implant Symposium, a two-day event that brings together foot and ankle specialists to present and attend lectures on the latest in foot and ankle topics. Dr. Adler will be speaking on the use of stem cells in the first MP (metacarpophalangeal) joint surgery. Stem Cell Replacement Therapy offers an advanced treatment option for problems like plantar fasciitis, Osteoarthritis, Achilles tendonitis and torn soft tissue. Stem Cell Replacement Therapy is proving to be much more effective and long lasting than traditional treatments. In the past common foot problems have been treated by physical therapy or orthotic therapy, but the results have often been poor, leaving patients continuing to struggle with the foot pain. Stem cells are used by many physicians to treat a broad variety of conditions because of their ability to either replicate themselves or change into the cell type that is needed to repair the tissue that has been damaged. The New York podiatrists at Adler Footcare introduce live birth stem cells into the affected area. When a patient comes in for stem cell therapy, the … Continue reading →

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