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Japan stem cell scientist calls for retraction of study

Posted: Published on March 11th, 2014

TOKYO: A co-author of a Japanese study that promised a revolutionary way to create stem cells has called for the headline-grabbing research to be retracted over claims its data was faulty. The findings, published by Japanese researcher Haruko Obokata and US-based scientists, outlined a simple and low-tech approach in the quest to grow transplant tissue in the lab. The study was touted as the third great advance in stem cells a futuristic field that aims to reverse Alzheimers, cancer and other crippling or lethal diseases. But it faced hard questions as the Japan-based Riken institute, which sponsored the study, launched a probe last month over the credibility of data used in the explosive findings. At issue are allegations that researchers used erroneous image data for an article published in the January edition of British journal Nature. Teruhiko Wakayama, a Yamanashi University professor who co-authored the article, called for a retraction. Its hard to believe the findings anymore after so many mistakes in the data, he told broadcaster Nippon Television late Monday. On Tuesday, the institute said it was mulling whether to pull back the study. We are considering whether to retract the report based on its credibility and research ethics, … Continue reading

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Is Skinny-Fat an Actual Health Problem?

Posted: Published on March 11th, 2014

When skier Lindsay Vonn referred to models as skinny-fat, saying that they have more cellulite than most people, she did more than solidify a new term: She brought into question a health issue thats perhaps been overlooked in the midst of an obesity epidemic. I see these people all the time, Dr. Daniel Neides, medical director at Cleveland Clinics Wellness Institute, told Time. On the outside they look incredibly healthy, but on the inside theyre a wreck. BLOG: How Calico Cats Could Help Cure Obesity The more technical term, normal-weight obesity, refers to people with a normal body mass index but a high percentage of the most dangerous type of body fat. People classified as skinny-fat usually dont exercise much and eat unhealthy diets. They face the same issues associated with obesity: type 2 diabetes, high blood pressure and high cholesterol. And new research suggests that these people are at the highest risk of metabolic problems and even death from cardiovascular diseases, Time reports. When youre eating a diet high in sugar and processed foods, it causes visceral fat storage, and that can lead to all sorts of risk factors of being overweight, Dr. Mark Hyman, author of The Blood … Continue reading

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Stem Cell Researcher Suggests Recalling His Own Study

Posted: Published on March 11th, 2014

By Maggie Fox One of the worlds leading stem cell experts has suggested withdrawing a study that made global headlines last January, saying he has questions about some of the images and data in it. The Japanese team, led by Teruhiko Wakayama, reported that they had created powerful stem cells by doing little more than soaking ordinary cells in an acid solution. The report, published in the journal Nature, impressed other stem cell researchers and opened the possibility of an easy approach to regenerative medicine. But Japanese television quotes Wakayama as saying he wants to take a closer look. "When conducting the experiment, I believed it was absolutely right, Reuters news agency quotes Wakayama as telling the television station NHK. "But now that many mistakes have emerged, I think it is best to withdraw the research paper once and, using correct data and correct pictures, to prove once again the paper is right," he said. "If it turns out to be wrong, we would need to make it clear why a thing like this happened." But Charles Vacanti of Harvard Medical School and Brigham and Women's Hospital in Boston, who helped work on the study, said he disagreed. "Some mistakes … Continue reading

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Stem cell center starting trials

Posted: Published on March 11th, 2014

Seven months after a bill to create a regional stem cell therapy hub at The University of Kansas Medical Center took effect, two doctors from the center say it is enrolling patients in clinical trials and they are beginning their work. David Prentice and Buddhadeb Dawn expressed excitement Monday about what the Midwest Stem Cell Therapy Center has been able to accomplish in a short time and what possibilities it holds for the future. "Kansas can be the leader in providing adult stem cell treatments and information to physicians and patients around the world," Dawn said. Prentice said the center, which limits itself to research on adult stem cells, will foster "ethical, noncontroversial" treatments for patients with multiple sclerosis, spinal cord injuries, heart damage, stroke and juvenile diabetes. At the same time he said it will serve to educate schoolchildren on the promise of adult stem cells and act as a "hub" for regional research. Potentially, physicians from across the region could be sending samples," Prentice told the Senate Ways and Means Committee that approved millions in start-up funds for the center last year. Sen. Jeff Melcher, R-Leawood, said he was heartened by news of the center beginning work, but … Continue reading

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Stem Cell Center advancing treatments, officials say

Posted: Published on March 11th, 2014

Topeka Eight months after the establishment of the Midwest Stem Cell Therapy Center at Kansas University Medical Center, the center is conducting clinical trials and advancing treatments for numerous diseases, KU officials said Monday. "We are very excited about the work that is going on," said Dr. Doug Girod, executive vice chancellor of the KU Medical Center. Dr. Buddhadeb Dawn, the center's director, detailed clinical trials that are under way and several in the planning stages to the Senate Ways and Means Committee. "These trials will help local patients to get access to stem cell therapy," Dawn said. "Kansas can be a leader in providing stem cell treatments." Created last year by the Legislature and Gov. Sam Brownback, the center will work on adult stem cell, cord blood and related stem cell research, providing therapies to patients and serving as a clearinghouse for physicians on cutting-edge treatments. The center is prohibited from using embryonic stem cells or cells taken from aborted fetal tissue. Abortion opponents oppose human embryonic stem cell research because it involves the destruction of the embryo. David Prentice, senior fellow for life sciences of the Family Research Council, said the center was unique in the country. Prentice, … Continue reading

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Cell Band-Aids could treat disease

Posted: Published on March 10th, 2014

Maxx Kirley, 12, gets so exhausted walking across his school that he cant participate in gym class once he gets there. He has Duchenne muscular dystrophy, a disease that weakens his muscles. But University research on certain poloxamers, named molecular Band-Aids, could provide a treatment option for Kirley. The groups of compounds can mend muscle cells with no side effects. University researchers are trying to apply these molecular Band-Aids to muscular dystrophy and heart disease, and are planning to start a clinical trial once they decide on the best version of the molecule to use. Having Duchenne muscular dystrophy means that Kirley lacks a large protein called dystrophin in his muscle cells. In healthy individuals, dystrophin absorbs the impact of everyday activities so that muscle cells can repair damage quickly, said Dr. Peter Karachunski, a pediatric neurologist at Amplatz Childrens Hospital. Without the protein, muscles deteriorate over time and even walking is strenuous, he said. The disease can lead to damage in almost every body system, and the life expectancy of a patient is about 20 years. He, first and foremost, is just a 12-year-old boy, Maxxs mother Terri Kirley said. Hes very smart, hes a student and he wants … Continue reading

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Zonegran (Zonisamide) Approved for Use in Children and Adolescents by Scottish Medicines Consortium (SMC)

Posted: Published on March 10th, 2014

HATFIELD, England, March 10, 2014 /PRNewswire/ -- Zonegran (zonisamide) has been approved by the Scottish Medicines Consortium (SMC) for the treatment of partial epilepsy in adolescents and children aged six years and above in Scotland.[1] This decision follows zonisamide's paediatric license extension approval by the European Commission (EC) on 3 October 2013. Already available in Scotland as adjunctive therapy for the treatment of partial seizures, with or without secondary generalisation, in adults, zonisamide is a second generation anti-epileptic drug (AED) with multiple mechanisms of action and a chemical structure unrelated to any other AEDs.[2] "Uncontrolled epilepsy can affect all aspects of children and their family's lives and so new, effective and well tolerated medications are always needed," commented Professor Martin Brodie, Director of the Epilepsy Unit at the Western Infirmary in Glasgow. "My extensive experience of treating adults with zonisamide in Scotland has demonstrated its effectiveness in reducing partial onset seizures[3] and I look forward to seeing this opportunity extended to children and adolescents." Epilepsy is one of the most common neurological diseases and affects around 54,000 people in Scotland.[4] Across the United Kingdom around 63,400 children and young people aged 18 years and under have epilepsy.[5] The successful treatment … Continue reading

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Best Local Autism Therapy Fort Lauderdale – Video

Posted: Published on March 10th, 2014

Best Local Autism Therapy Fort Lauderdale Looking for a Psychiatrist or Psychologist? Know Someone Experiencing Depression, Anxiety or Bipolar Disorder? Watch Informative Guides to Recognize Early Sy... By: BestLocal Fort Lauderdale … Continue reading

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Advocates unhappy with autism bill rewrite

Posted: Published on March 10th, 2014

A long-sought bill mandating insurance coverage for childhood autism treatment was described as a compromise Monday, but several advocates said it had been too watered-down to mollify the insurance industry. Monday's testimony was scheduled for proponents of House Bill 2744, but several of those who testified Monday said the bill was now unacceptable due to coverage caps and provider licensing requirements. "If you were in my position, would you vote for this bill or not?" Rep. John Doll, R-Garden City, asked Mike Wasmer, an Olathe resident and representative from Autism Speaks. "I would not," Wasmer said. Rep. Barbara Bollier, R-Mission Hills, asked early in the hearing where the bill came from, which she later said was an attempt to discern who had been at the table when it was devised. "I needed a reference point when they said 'this is a compromise,'" Bollier explained after the hearing. "I needed to know what that meant and who were the compromisers." Wasmer said the compromise was between insurance companies not eager to see an autism mandate go forward and Rep. John Rubin, R-Shawnee, who has promoted the mandate for years. "No parent, no provider group, no parent advocacy group was at the … Continue reading

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New guidelines employ a team approach to autism diagnosis, care

Posted: Published on March 10th, 2014

Improving diagnosis and treatment for individuals with autism has been the focus of a growing body of research. New information from these studies led the American Academy of Child and Adolescent Psychiatry to revise key parameters for evaluating and treating autism. Researchers led by Yale Child Study Center director Fred Volkmar, M.D., have published the new practice parameters in the Feb. issue of the Journal of the American Academy of Child and Adolescent Psychiatry. "Early diagnosis of children with autism spectrum disorders means treatments will be introduced that lead to more positive outcomes for children," said Volkmar the Irving B. Harris Professor of Psychiatry, Pediatrics, and Psychology at the Yale School of Medicine. According to the parameters, clinicians should routinely look for symptoms of autism spectrum disorder in young children undergoing developmental assessments, and in all psychiatric evaluations. If significant symptoms are detected, clinicians should then coordinate a careful medical, psychological, and communication evaluation. These evaluations should differentiate between autism and a variety of developmental and other disorders, as well as intellectual and behavioral disabilities. "Our goal was advocacy for individuals with autism and their families, and to ensure that services are coordinated across clinical care," said Volkmar. "Our field … Continue reading

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