Contact Information Available for logged-in reporters only Newswise The McGovern Institute for Brain Research at MIT announced today that Huda Y. Zoghbi, of Baylor College of Medicine and Texas Childrens Hospital, is the winner of the 2014 Edward M. Scolnick Prize in Neuroscience. The Prize is awarded annually by the McGovern Institute to recognize outstanding advances in the field of neuroscience. Huda Zoghbi has been a pioneer in the study of human genetic disease, says Robert Desimone, director of the McGovern Institute and chair of the selection committee. Her work has provided fundamental insights into the mechanisms of hereditary neurodegenerative and neuropsychiatric diseases, and has pointed the way to new treatments for these disorders. Zoghbi studied medicine in her native Lebanon and later in the US, where she specialized in pediatric neurology. Following her residency she trained as a molecular geneticist with Arthur Beaudet at Baylor College of Medicine, where she became a faculty member in 1988. She is currently an investigator with the Howard Hughes Medical Institute. Zoghbis first major scientific contribution was the identification in 1993 of the gene responsible for spinocerebellar ataxia type 1 (SCA1), a progressive neurodegenerative disease with an unusual pattern of inheritance. In collaboration … Continue reading →

PUBLIC RELEASE DATE: 4-Mar-2014 Contact: John Ascenzi ascenzi@email.chop.edu 267-426-6055 Children's Hospital of Philadelphia Two recent genetic studies expand the list of genes involved with body fat and body mass index, and their connection to major Western health problems: heart disease, high blood pressure and diabetes. One study showed that higher body mass index (BMI) caused harmful effects on the risk of type 2 diabetes, high blood pressure and inflammation, while another study found gene signals linked to higher levels of body fat metrics, without showing causality. "These findings are highly relevant to the obesity pandemic in the United States and many other countries," said geneticist Brendan J. Keating, D. Phil., of the Center for Applied Genomics at The Children's Hospital of Philadelphia. "Of course, much research remains to be performed to discover further genes involved in these complex metabolic diseases, and to better understand how to improve treatments." Keating, who previously helped create a large gene-discovery tool called the Cardio Chip, was a co-leader of both studies, which drew on large international teams of scientists using DNA, laboratory and disease data from tens of thousands of people. In the BMI research, published in the Feb. 6 issue of the American … Continue reading →

FORTUNE --FirstMark Capital is known for investing in consumer-facing software companies like Pinterest, Riot Games, and Aereo, as well as enterprise deals. But since Matt Turck, a former investor with Bloomberg Ventures, joined the firm one year ago, he's been looking at deals that are more out-there, related to big data and the Internet of Things. Take, for example, his latest investment: Recombine, a bioinformatics company. Alongside new early-stage firm Vast Ventures, FirstMark has invested $3.3 million in the New York-based startup. Angel investors who participated in the round include Vivek Garipalli, formerly of Blackstone Group (BX), as well as Alexander Saint-Amand, President and CEO of Gerson Lehrman Group, and Zach Weinberg and Nat Turner, who co-founded health care startup Flatiron Health. Currently, Recombine provides clinical genetic testing services which are faster and cheaper than those offered by LabCo Diagnostic Network and Quest Diagnostics (DGX), the incumbent providers. Those companies' technology, much of which was created in the 1970s, requires a separate test (and separate blood samples) to test for each individual disease, and it costs up to $1,000 for each test. Recombine tests for 213 genetic disorders at once, costing $500 before insurance. MORE:Apple's CFO says see you in … Continue reading →

Contact Information Available for logged-in reporters only Newswise Philadelphia, March 4, 2014 Two recent genetic studies expand the list of genes involved with body fat and body mass index, and their connection to major Western health problems: heart disease, high blood pressure and diabetes. One study showed that higher body mass index (BMI) caused harmful effects on the risk of type 2 diabetes, high blood pressure and inflammation, while another study found gene signals linked to higher levels of body fat metrics, without showing causality. These findings are highly relevant to the obesity pandemic in the United States and many other countries, said geneticist Brendan J. Keating, D. Phil., of the Center for Applied Genomics at The Childrens Hospital of Philadelphia. Of course, much research remains to be performed to discover further genes involved in these complex metabolic diseases, and to better understand how to improve treatments. Keating, who previously helped create a large gene-discovery tool called the Cardio Chip, was a co-leader of both studies, which drew on large international teams of scientists using DNA, laboratory and disease data from tens of thousands of people. In the BMI research, published in the Feb. 6 issue of the American Journal … Continue reading →

PUBLIC RELEASE DATE: 4-Mar-2014 Contact: Vicki Cohn vcohn@liebertpub.com 914-710-2100 Mary Ann Liebert, Inc./Genetic Engineering News New Rochelle, NY, March 4, 2014Only about 37% of babies around the world are exclusively breastfed for the first 6 months of life, as recommended by the World Health Organization (WHO). The benefits of breastfeeding for both infants and mothers are well-established. The effectiveness of different types of interventions for promoting exclusive breastfeeding in high-income countries is the focus of a Review article published in Breastfeeding Medicine, the official journal of the Academy of Breastfeeding Medicine published by Mary Ann Liebert, Inc., publishers. The article is available free on the Breastfeeding Medicine website at http://www.liebertpub.com/bfm. Most interventions designed to encourage women to breastfeed use supportive or educational approaches, with varying levels of success, according to study authors Helen Skouteris and colleagues from Deakin University and University of Melbourne (Melbourne, Australia), and Leeds Metropolitan University (Leeds, UK). In the article "Interventions Designed to Promote Exclusive Breastfeeding in High-Income Countries: A Systematic Review" the authors evaluate the effectiveness of different interventions, comparing prenatal and postnatal approaches, the duration of the interventions, and identify whether they focus on educating mothers or providing emotional support. "The search for successful … Continue reading →