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3-D microgels ‘on-demand’ offer new potential for cell research, the future of personalized medicine

Posted: Published on February 27th, 2014

Stars, diamonds, circles. Rather than your average bowl of Lucky Charms, these are three-dimensional cell cultures generated by an exciting new digital microfluidics platform, the results of which have been published in Nature Communications this week by researchers at the University of Toronto. The tool, which can be used to study cells in cost-efficient, three-dimensional microgels, may hold the key to personalized medicine applications in the future. "We already know that the microenvironment can greatly influence cell fate," says Irwin A. Eydelnant, recent doctoral graduate from IBBME and first author of the publication. "The important part of this study is that we've developed a tool that will allow us to investigate the sensitivity of cells to their 3D environment." "Everyone wants to do three-dimensional (3D) cell culture," explains Aaron Wheeler, Professor and Canada Research Chair in Bioanalytical Chemistry at the Institute of Biomaterials & Biomedical Engineering (IBBME), the Department of Chemistry, and the Donnelly Centre for Cellular and Biomolecular Research (DCCBR) at the University of Toronto. "Cells grown in this manner share much more in common with living systems than the standard two-dimensional (2D) cell culture format," says Wheeler, corresponding author of the study. More naturalistic, 3D cell cultures are … Continue reading

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3D microgels ‘on-demand’ offer new potential for cell research

Posted: Published on February 27th, 2014

PUBLIC RELEASE DATE: 26-Feb-2014 Contact: Erin Vollick comm.ibbme@utoronto.ca 416-946-8019 University of Toronto Stars, diamonds, circles. Rather than your average bowl of Lucky Charms, these are three-dimensional cell cultures generated by an exciting new digital microfluidics platform, the results of which have been published in Nature Communications this week by researchers at the University of Toronto. The tool, which can be used to study cells in cost-efficient, three-dimensional microgels, may hold the key to personalized medicine applications in the future. "We already know that the microenvironment can greatly influence cell fate," says Irwin A. Eydelnant, recent doctoral graduate from IBBME and first author of the publication. "The important part of this study is that we've developed a tool that will allow us to investigate the sensitivity of cells to their 3D environment." "Everyone wants to do three-dimensional (3D) cell culture," explains Aaron Wheeler, Professor and Canada Research Chair in Bioanalytical Chemistry at the Institute of Biomaterials & Biomedical Engineering (IBBME), the Department of Chemistry, and the Donnelly Centre for Cellular and Biomolecular Research (DCCBR) at the University of Toronto. "Cells grown in this manner share much more in common with living systems than the standard two-dimensional (2D) cell culture format," says … Continue reading

Posted in Cell Medicine | Comments Off on 3D microgels ‘on-demand’ offer new potential for cell research

3-D microgels ‘on-demand’ offer new potential for cell research

Posted: Published on February 27th, 2014

PUBLIC RELEASE DATE: 26-Feb-2014 Contact: Erin Vollick comm.ibbme@utoronto.ca 416-946-8019 University of Toronto Stars, diamonds, circles. Rather than your average bowl of Lucky Charms, these are three-dimensional cell cultures generated by an exciting new digital microfluidics platform, the results of which have been published in Nature Communications this week by researchers at the University of Toronto. The tool, which can be used to study cells in cost-efficient, three-dimensional microgels, may hold the key to personalized medicine applications in the future. "We already know that the microenvironment can greatly influence cell fate," says Irwin A. Eydelnant, recent doctoral graduate from IBBME and first author of the publication. "The important part of this study is that we've developed a tool that will allow us to investigate the sensitivity of cells to their 3D environment." "Everyone wants to do three-dimensional (3D) cell culture," explains Aaron Wheeler, Professor and Canada Research Chair in Bioanalytical Chemistry at the Institute of Biomaterials & Biomedical Engineering (IBBME), the Department of Chemistry, and the Donnelly Centre for Cellular and Biomolecular Research (DCCBR) at the University of Toronto. "Cells grown in this manner share much more in common with living systems than the standard two-dimensional (2D) cell culture format," says … Continue reading

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DNA test better than standard screens in identifying fetal chromosome abnormalities

Posted: Published on February 27th, 2014

PUBLIC RELEASE DATE: 26-Feb-2014 Contact: Jeremy Lechan jlechan@tuftsmedicalcenter.org 617-636-0104 Tufts Medical Center BOSTON (Feb. 27) A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18. A team of scientists, led by Diana W. Bianchi, MD, Executive Director of the Mother Infant Research Institute at Floating Hospital for Children at Tufts Medical Center, reports the results of their clinical trial using non-invasive cell-free DNA prenatal testing in a general obstetrical population of pregnant women, in an article entitled "DNA sequencing versus standard prenatal aneuploidy screening." The multi-center, blinded study analyzed samples from 1,914 pregnant women, and found that noninvasive cfDNA testing had a ten-fold improvement in the positive predictive value for trisomy 21, commonly known as Down syndrome, compared to standard prenatal aneuploidy screening methods (aneuploidy is a term for one or more extra or missing chromosomes). … Continue reading

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Left Bicep Tendon Injection | Stem Cell Therapy | Stem Cell Injection – Video

Posted: Published on February 26th, 2014

Left Bicep Tendon Injection | Stem Cell Therapy | Stem Cell Injection Eterna MD specializes in stem cell therapy and treatment. This particular case stem cells were injected into the left bicep tendon through an ultrasound guid... By: Eterna MD Regenerative Medicine … Continue reading

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Stem Cell Replacement Therapy for Common Foot Injuries Provides Rapid Healing

Posted: Published on February 26th, 2014

New York, New York (PRWEB) February 26, 2014 Adler Footcare of Greater New York is offering an advanced treatment option for chronic foot problems like plantar fasciitis, as well as common foot problems like Osteoarthritis, Achilles tendonitis and torn soft tissue. In the past these conditions have been treated by physical therapy or orthotic therapy, but the results have often been poor, leaving patients continuing to struggle with the pain. With stem cell replacement therapy, the treatment of these conditions is proving far more effective and long lasting than traditional treatments. At Adler Footcare we use live birth stem cells which are introduced into the affected area. Stem cells are used by many physicians to treat a broad variety of conditions because of their ability to either replicate themselves, or change into the cell type that is needed to repair the tissue that has been damaged. When a patient comes in for stem cell therapy, the affected area is carefully measured so the stem cells can be delivered directly to the area that needs the treatment. The Joint Commission accredited Podiatric OR of Midtown Manhattan housed within Adler Footcare is designed to facilitate advanced treatments such as Stem Cell Replacement … Continue reading

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SEOUL: STC Life Co., Ltd. Successfully Treats Patients …

Posted: Published on February 26th, 2014

SEOUL Stem cell research institute of STC Life Co., Ltd. (Chairman: KYE HO LEE) and 97.7 B&H Clinic (Director: WON JU JUNG) successfully completed mesenchymal stem cell therapy for the patients with Parkinsons disease, a chronic progressive degenerative disease in nervous system. Parkinsons disease is caused when dopamine nerve cells distributed in substance nigra become gradually extinct. It is a chronic progressive degenerative disease characteristically showing quiver, stiffness, bradykinesia and postural instability. General medicine treatment has no effect on Parkinsons disease and there are no other treatments for it. 97.7 B&H Clinic (Representative Director: WON JU JUNG, http://www.977bnh.com) administered stem cell into vein of the patients with Parkinsons disease 3 times every 2 weeks. Mesenchymal stem cell, one of the adult stem cells, is used a lot for neogenesis, and stem cell research institute (Director: SANG YEON LEE) of STC Life Co., Ltd. used stem cells separated from umbilical cord of fetus. The patients who got stem cell therapy showed remarkable reduction of the symptoms such as lalopathy and paralysis of arms and legs and also showed satisfactory progress to be able to do light exercise. Furthermore, their linguistic ability, visual function and memory have increased and have not shown … Continue reading

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Stem cells from osteoarthritis patients as good as controls – Video

Posted: Published on February 26th, 2014

Stem cells from osteoarthritis patients as good as controls http://wwwarthritistreatmentcenter.com Stem cells from patients with osteoarthritis are as good as normal controls Alwin Scharstuhl and colleagues, in an art... By: Nathan Wei … Continue reading

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Nuclear stiffness keeps stem cells, cancer cells in place

Posted: Published on February 26th, 2014

Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability; having a flexible nucleus makes migration easier but is worse at protecting the nucleus' DNA compared to a stiffer nucleus. Nuclear proteins that regulate nuclear stiffness are therefore thought to control processes as diverse as tissue repair and tumor growth. In a study published in the Journal of Cell Biology, researchers at the University of Pennsylvania have shown that cell migration through micron-size pores is regulated by lamin-A, a nuclear protein that is very similar to the fibrous ones that make up hair. They have also shown that a cell's ability to survive the mechanical stress of migration depends on proteins called "heat shock factors." Using an anti-cancer drug that inhibits heat shock responses, they showed that this drug's effectiveness relies on inhibiting the invasive migration of cells via the same mechanism. Taking into account the role that lamin-A plays in increasing nuclear stiffness could help stem cell biologists and cancer clinicians interpret the diversity of nuclear shapes seen in a static sample of tissue … Continue reading

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RoosterBio Inc, a Frederick Maryland Biotech Startup, Achieves Rapid Traction with Product Launch and Fundraising …

Posted: Published on February 26th, 2014

Frederick, MD (PRWEB) February 25, 2014 RoosterBio Inc is a new biotech start-up supplying human bone marrow-derived Mesenchymal Stem Cells (hBM-MSC) for tissue engineering research and stem cell-based product development into the high growth Synthetic Biology and Regenerative Medicine fields. RoosterBio, Inc. initiated laboratory operations in October, 2013, and has achieved the critical milestone of first product shipment to paying customers in just four short months. In addition to the early validation of their business model and rapidly generating revenue, Roosterbio has raised over 250K in seed investment and are actively seeking funds via AngelList (https://angel.co/roosterbio). RoosterBio credits their quick-to-market accomplishments to hyper-efficient operations and the passion that the RoosterBio team shares in their desire to assist tissue engineers and cell therapists to accelerate life-saving technologies into the clinic. Our laser focus coupled with operational excellence has enabled us to reach these milestones; we will delight our customers with our product offering, says Chief Operating Officer, Dr. Uplaksh Kumar. The RoosterBio teams extensive experience sourcing raw materials, manufacturing stem cell products, and controlling for high quality with best-in-class characterization techniques has allowed them to successfully launch their flagship hBM-MSC product quickly and efficiently. Dr. Jon Rowley, RoosterBios Chief Executive said … Continue reading

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