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Deep TCR sequencing reveals extensive renewal of the T cell repertoire following autologous stem cell transplant in MS

Posted: Published on February 20th, 2014

A new study describes the complexity of the new T cell repertoire following immune-depleting therapy to treat multiple sclerosis, improving our understanding of immune tolerance and clinical outcomes. In the Immune Tolerance Network's (ITN) HALT-MS study, 24 patients with relapsing, remitting multiple sclerosis received high-dose immunosuppression followed by a transplant of their own stem cells, called an autologous stem cell transplant, to potentially reprogram the immune system so that it stops attacking the brain and spinal cord. Data published in the Journal of Clinical Investigation quantified and characterized T cell populations following this aggressive regimen to understand how the reconstituting immune system is related to patient outcomes. ITN investigators used a high-throughput, deep-sequencing technology (Adaptive Biotechnologies, ImmunoSEQTM Platform) to analyze the T cell receptor (TCR) sequences in CD4+ and CD8+ cells to compare the repertoire at baseline pre-transplant, two months post-transplant and 12 months post-transplant. Using this approach, alongside conventional flow cytometry, the investigators found that CD4+ and CD8+ lymphocytes exhibit different reconstitution patterns following transplantation. The scientists observed that the dominant CD8+ T cell clones present at baseline were expanded at 12 months post-transplant, suggesting these clones were not effectively eradicated during treatment. In contrast, the dominant CD4+ T … Continue reading →

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Victim's family speaks out one year after cosmetic surgery death

Posted: Published on February 20th, 2014

SAVANNAH, GA (CBS ATLANTA) - One year ago this week, April Jenkins died after having cosmetic surgery at a metro Atlanta med spa. For the first time, Jenkins' father, Hal Jenkins, is talking about that tragic day and wondering why the Georgia Medical Board hasn't taken action against the doctor. "She was the love of our life, she was everything to us," Hal Jenkins said. "It's just very hurtful to even talk about her because I miss her so much." April Jenkins died last February while undergoing liposuction performed by Dr. Nedra Dodds at Opulence Aesthetic Medicine in Kennesaw. "She didn't take care of my sister and that hurts me to this day," April Jenkins' sister, Audrey Jenkins, said. Employees in the operating room during the procedure said April Jenkins complained that it was "tearing and burning." They also told police a rag was placed in April Jenkins' mouth to quiet her. The medical examiner found a perforation in April Jenkins' diaphragm as well as multiple puncture wounds to her liver. "Someone that's supposed to be professional and they let something like this happen to her. I can't understand it," Hal Jenkins said. Even though it's been a year since … Continue reading →

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Pennsylvania Hospital Opens Philadelphia's First All-Private Maternity Suite Unit

Posted: Published on February 20th, 2014

Contact Information Available for logged-in reporters only Newswise PHILADELPHIA After three years of renovations and new construction,Pennsylvania HospitalofPenn Medicinewill unveil its newWell Mother & Baby Uniton February 26. The hospital, where nearly 5,000 babies are delivered each year the most in the City of Philadelphia will now offer three full floors of all private rooms dedicated solely to new mothers and their newborns. The opening of the new unit is part of Pennsylvania Hospitals (PAH) $61 million long-range facility master plan. Pennsylvania Hospital has a long history as a premier hospital for obstetrical services in Philadelphia, so were really excited to expand our offerings by providing private rooms to all of our maternity patients, saidR. Michael Buckley, MD,the hospitals executive director. PAH is the first hospital in the City of Philadelphia to offer all private maternity suites. Mothers and their babies progress to Well Mother & Baby private rooms following their labor and delivery. Each new suite offers contemporary and comfortable furniture, soft colors, subdued lighting, a flat screen television, and a spacious restroom layout with an open shower stall. New suites also include a full-sized convertible sofa sleeper to provide overnight accommodations for a family member or friend, combination … Continue reading →

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Dr. German Newall Now Offering New Prineo Wound Closure System

Posted: Published on February 20th, 2014

Houston, TX (PRWEB) February 19, 2014 Dr. German Newall from the Aesthetic Center for Plastic Surgery has recently started using the Dermabond Prineo Wound Closure System introduced by Johnson & Johnson. Dr. Newall has seen outstanding results so far from the first patients to use the system. Johnson & Johnson introduced the wound closure system as an aid to the healing of surgical incisions and to improve the appearance of scars left by surgical incisions. The product is applied on the operating table immediately following the procedure when the incision is closed and remains there for six weeks following surgery. The use of the product requires no action on the part of the patient. In the few weeks the wound closure system has been available, Dr. Newall has used the product on tummy tuck patients, breast lift patients, brachioplasty and body lift patients. Dr. Newall has seen remarkably positive results so far. Dr. Newall is a leading body contouring surgeon, particularly in the area of large-volume liposuction to reshape the body. He has been recognized as one of the top doctors in Houston and is highly respected by his peers. His expertise includes body contouring, breast enhancement and facial rejuvenation. … Continue reading →

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Duke Health System CEO appointed to head Institute of Medicine

Posted: Published on February 20th, 2014

Duke University Health SystemDr. Victor J. Dzau, the current president and CEO of Duke University Health System Dr. Victor J. Dzau, the current president and CEO of Duke University Health System and chancellor for health affairs at Duke University, has been appointed to a six-year term as the next president of the Institute of Medicine (IOM), effective July 1, 2014. Dr. Dzau will take over the lead role from Dr. Harvey Fineberg, who served in the position for twelve years. Dr. Dzau began his career in medicine as a cardiologist, having previously taught at Harvard Medical School and served as chair of the department of medicine. He also worked at Brigham and Womens Hospital as the director of research. His ongoing award-winning research has been key in the development of cardiovascular drugs, as well as techniques to repair tissue damage from heart attacks and heart disease using stem cell therapies. Dr. Eugene Braunwald, often called the father of modern cardiology and a professor of medicine at Harvard Medical School, has known Dr. Dzau for more than 40 years and worked with him at many different stages of his career at Brigham and Womens Hospital and Partners Healthcare. In an interview … Continue reading →

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Laminine Testimonial – Chronic Kidney Disease – Video

Posted: Published on February 20th, 2014

Laminine Testimonial - Chronic Kidney Disease Laminine is availabe in the Philippines!!! "The Closest Alternative To Stem Cell Therapy..." "The miracle formula from a 9-day-old fertilized hen eggs" For M... By: Julfran Ytang … Continue reading →

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Stem Cells Being Used To Treat Knee, Joint Pain

Posted: Published on February 20th, 2014

CBS Pittsburgh (con't) Affordable Care Act Updates: CBSPittsburgh.com/ACA Health News & Information: CBSPittsburgh.com/Health PITTSBURGH (KDKA) After injuries from gymnastics and dance when she was younger, Linda Morning-Starpoole was having terrible knee pain. Sitting and standing up and getting up and moving, Linda said. The news from her orthopedic surgeon was not encouraging. I was sent off with a prescription, and basically said, take this, and when it gets so bad, well take out your knees. And that was really upsetting to me. It was such an ugly picture that was painted for my future, Linda said. Traditional treatment might involve steroid injections, physical therapy, and joint replacement. But Linda wanted an alternative. When she first heard about using stem cell injections, she was very intrigued. The thought of me healing me with my own self is what sold me on the procedure, Linda said. Go here to read the rest: Stem Cells Being Used To Treat Knee, Joint Pain … Continue reading →

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Stem Cell Treatment at "EmCell" – Video

Posted: Published on February 20th, 2014

Stem Cell Treatment at "EmCell" http://www.emcell.com/ Stem cell therapy is the rapidly developing area of modern medicine. Unique properties of fetal stem cells, the core of EmCell treatme... By: Stem Cell Therapy Center "EMCELL" … Continue reading →

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CardioCell begins 2 heart stem cell trials

Posted: Published on February 20th, 2014

CardioCell has begun two new clinical trials of its stem cell treatment for recent heart attack patients, the San Diego company said Wednesday. A Phase 3 trial has started in Kazakhstan and a Phase 2a trial in the United States, said privately held CardioCell. The stem cells are grown under low oxygen conditions, similar to the natural environment of stem cells in the body, said cardiologist Stephen Epstein, a scientific advisor. Stem cells grown under higher levels of oxygen common in laboratory environments act differently than those grown in low oxygen levels, which may reduce their regenerative abilities, said Epstein, director of translational and vascular biology research at MedStar Heart Institute in Washington, D.C. Moreover, these cells tolerate ischemia, a reduced blood supply that limits the availability of oxygen and nutrients. Since heart attacks are by definition caused by ischemia, that tolerance should help the cells survive long enough to help, Epstein said. The stem cells appear to help by producing chemicals that stimulate heart regeneration, Epstein said. The stem cells are of a type called mesenchymal, taken from bone marrow. They were produced by Stemedica, another San Diego stem cell company, which spun off CardioCell. More information about the … Continue reading →

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Autism Drug Studied On Animals Has Potential For Humans

Posted: Published on February 19th, 2014

By Marcus Johnson Bumetanide is a drug approved for the treatment of heart and liver disease. It is now being repurposed to treat autism and researchers are in the first stages of studying the drug. Researchers would like to know if bumetanide can stop or reverse autism in children and theyve started by testing the drug on animals such as mice and rats. Researchers found that bumetanide reversed a faulty birth mechanism that may have led to autism symptoms in offspring. The next step for researchers is to test bumetanide on children. Researchers who have worked on the studies are optimistic. If you administer a diuretic to the mother 24 hours before delivery, the offspring is, so to speak, cured, said Yehezkel Ben-Ari, the study author. What we must do is work in the development and biology earlier so we see, this is insufficient and how we can treat it earlier. While the studys results are positive, it is not yet determined if the drugs effects on animals will be similar in humans. G. Ian Gallicano, a biologist at Georgetown, is skeptical. I think 90 percent of this paper is really earth-shattering, but there's always the caution of, 'is this … Continue reading →

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