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Protein Switch Dictates Cellular Fate: Stem Cell or Neuron

Posted: Published on February 14th, 2014

Contact Information Available for logged-in reporters only Newswise Researchers at the University of California, San Diego School of Medicine have discovered that a well-known protein has a new function: It acts in a biological circuit to determine whether an immature neural cell remains in a stem-like state or proceeds to become a functional neuron. The findings, published in the February 13 online issue of Cell Reports, more fully illuminate a fundamental but still poorly understood cellular act and may have significant implications for future development of new therapies for specific neurological disorders, including autism and schizophrenia. Postdoctoral fellow Chih-Hong Lou, working with principal investigator Miles F. Wilkinson, PhD, professor in the Department of Reproductive Medicine and a member of the UC San Diego Institute for Genomic Medicine, and other colleagues, discovered that this critical biological decision is controlled by UPF1, a protein essential for the nonsense-mediated RNA decay (NMD) pathway. NMD was previously established to have two broad roles. First, it is a quality control mechanism used by cells to eliminate faulty messenger RNA (mRNA) molecules that help transcribe genetic information into the construction of proteins essential to life. Second, it degrades a specific group of normal mRNAs. The latter … Continue reading

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Total Recovery Lecture Series: Novel Treatments for Joint, Tendon & Ligament Pain, Part 3 – Video

Posted: Published on February 14th, 2014

Total Recovery Lecture Series: Novel Treatments for Joint, Tendon Ligament Pain, Part 3 Part 3: Regenerative Therapies: Prolotherapy, Platelet Rich Plasma (PRP) and Stem Cell Therapy Dr. David Wang, Harvard trained and Board Certified in Physica... By: KaplanCenter … Continue reading

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10. Spinal Cord Injury (L1)with stem cell treatment(after) – Video

Posted: Published on February 14th, 2014

10. Spinal Cord Injury (L1)with stem cell treatment(after) Name: Wu Age: 22 Diagnosis: Spinal Cord Injury (L1) Wu got L1 damage on 9th, June 2011 when he was 22 years old. After emergent surgery, he started rehabilit... By: Cells Center China … Continue reading

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Dr Foglietti – Popular Radio Personality Undergoes Experimental Stem Cell Treatment – Video

Posted: Published on February 14th, 2014

Dr Foglietti - Popular Radio Personality Undergoes Experimental Stem Cell Treatment Dr Foglietti - Popular Radio Personality Undergoes Experimental Stem Cell Treatment by Dr. Foglietti. By: DrFoglietti … Continue reading

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K-9 Stem Cell Treatment: Rusty Recovers – Video

Posted: Published on February 14th, 2014

K-9 Stem Cell Treatment: Rusty Recovers http://www.dogstoryvideos.com In this 7 minute video, Terry Wainscott of Rusty's Discount Pet Center in Studio City, CA discusses a recent stem cell treatmen... By: DogStoryVideos.com … Continue reading

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12. Language Improvement of CP Kid Treated by Stem Cell Treatment (Before) – Video

Posted: Published on February 14th, 2014

12. Language Improvement of CP Kid Treated by Stem Cell Treatment (Before) You can find the significant improvement of this kid. His name is Wen wen, 10 years old. He accepted stem cell treatment in June of 2011, one time brain ster... By: Cells Center China … Continue reading

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12. Language Improvement of CP Kid Treated by Stem Cell Treatment (After) – Video

Posted: Published on February 14th, 2014

12. Language Improvement of CP Kid Treated by Stem Cell Treatment (After) You can find the significant improvement of this kid. His name is Wen wen, 10 years old. He accepted stem cell treatment in June of 2011, one time brain ster... By: Cells Center China … Continue reading

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13. Stem Cell Treatment for CP Caused by Cerebral Atrophy (Before) – Video

Posted: Published on February 14th, 2014

13. Stem Cell Treatment for CP Caused by Cerebral Atrophy (Before) Patient Name: Rong Rong Gender: female Age:4 Medical history: Rong experienced 28 days' high fever when she was 11 months old. And then began to have epileps... By: Cells Center China … Continue reading

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13. Stem Cell Treatment for CP Caused by Cerebral Atrophy (After) – Video

Posted: Published on February 14th, 2014

13. Stem Cell Treatment for CP Caused by Cerebral Atrophy (After) Patient Name: Rong Rong Gender: female Age:4 Medical history: Rong experienced 28 days' high fever when she was 11 months old. And then began to have epileps... By: Cells Center China … Continue reading

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16. Case of MND Treated with Stem Cell Treatment (After) – Video

Posted: Published on February 14th, 2014

16. Case of MND Treated with Stem Cell Treatment (After) Case of MND Treated with Stem Cell Treatment Mrs.Lee was 61 years old, from Jiang xi Province. Her disease started from September of 2004. And she was diagno... By: Cells Center China … Continue reading

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