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4D Molecular Therapeutics Strengthens Leadership Team with Key Appointments in Clinical Research and Development – BioSpace

Posted: Published on December 8th, 2020

4DMT has made tremendous progress since the close of our Series C financing. We have advanced product candidates across our key therapeutic areas of ophthalmology, cardiology and pulmonology, including the initiation of the clinical programs for 4D-110 and 4D-125 in ophthalmology, and 4D-310 for the treatment of Fabry disease, said David Kirn, M.D., co-founder and chief executive officer of 4DMT. With the addition of Robert Fishman, Raphael Schiffmann and Robert Kim to our clinical R&D leadership team, 4DMT gains not only extensive experience in clinical development and translational medicine, but also unique and specific experience within each of the initial 4DMT therapeutic areas. Continue reading

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Chiesi USA Appoints Jon Zwinski as General Manager and Chief Executive Officer – BioSpace

Posted: Published on December 8th, 2020

Jon Zwinski succeeds Ken McBean as company advances global therapeutic efforts CARY, N.C., Dec. 08, 2020 (GLOBE NEWSWIRE) -- Chiesi, USA (Formerly Known As Cornerstone Therapeutics)(key-ay-zee), the U.S. Continue reading

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Congenital absence of the right coronary artery with acute myocardial infarction: report of two cases and review of the literature – DocWire News

Posted: Published on December 8th, 2020

This article was originally published here J Int Med Res. Continue reading

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Effect of Secondary Prevention Medication on the Prognosis in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease -…

Posted: Published on December 8th, 2020

This article was originally published here J Cardiovasc Pharmacol. 2020 Dec;76(6):678-683. Continue reading

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Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not – Medscape

Posted: Published on December 8th, 2020

Coronary artery calcium (CAC) score as a measure of plaque burden more reliably predicts future cardiovascular (CV) risk in patients with suspected coronary disease (CAD) than whether or not the disease is obstructive, a large retrospective study suggests. Continue reading

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Dec 4 2020 This Week in Cardiology – Medscape

Posted: Published on December 8th, 2020

Please note that the text below is not a full transcript and has not been copyedited. Continue reading

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Pooled Analysis of 4 Clinical Trials Reflects Low Cardiac Risk With Acalabrutinib in CLL – OncLive

Posted: Published on December 8th, 2020

Patients with chronic lymphocytic leukemia (CLL) who received treatment with single-agent acalabrutinib (Calquence) experienced a low incidence of cardiac toxicities leading to treatment discontinuation, according to data from a pooled analysis across 4 clinical trials presented during the 2020 ASH Annual Meeting & Exposition.1 Results showed that 17% (n = 129) of 762 patients with CLL who received treatment with the second-generation BTK inhibitor as a monotherapy experienced cardiac toxicity of any grade at a median follow-up of 25.9 months, which led to treatment discontinuation in 7 patients (0.9%). Continue reading

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Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study – The BMJ

Posted: Published on December 8th, 2020

Abstract Objective To determine the association between levels of low density lipoprotein cholesterol (LDL-C) and all cause mortality, and the concentration of LDL-C associated with the lowest risk of all cause mortality in the general population. Design Prospective cohort study Continue reading

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Impact of Bleeding During Dual Antiplatelet Therapy in Patients with Coronary Artery Disease – DocWire News

Posted: Published on December 8th, 2020

This nationwide retrospective cohort study used the National Health Insurance Research Database of Taiwan to compare the impact of bleeding on clinical outcomes in patients with acute myocardial infarction (AMI) versus chronic coronary syndrome (CCS). Continue reading

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Fracking Sites Tied to Increased Heart Failure Hospitalizations – Medscape

Posted: Published on December 8th, 2020

Living near hydraulic fracturing is associated with increased risk of hospitalization in people with heart failure (HF), a new study from Pennsylvania suggests. The link was strongest among those with more severe heart failure but patients with either HF phenotype showed this association of increased risk with exposure to fracking activities, according to the investigators, led by Tara P. McAlexander, PhD, MPH, Drexel University Dornsife School of Public Health in Philadelphia Continue reading

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