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Penn Medicine and CHOP Study: New Genetic Analysis Confirms Connection Between Cholesterol and Heart Disease

Posted: Published on February 11th, 2014

PHILADELPHIA New research is adding to a growing body of evidence showing the effects that genetics, cholesterol and other lipids in the blood have on coronary heart disease (CHD). Previous research has shown elevated levels of low-density lipoprotein cholesterol (LDLc, commonly known as bad cholesterol) are known to cause heart disease, but the effects of other lipids such as high-density lipoprotein cholesterol (HDLc, or good cholesterol) and triglycerides (TG) have been less clear. In a new study, published online in the European Heart Journal, an international team led by researchers at the Perelman School of Medicine at the University of Pennsylvania and the Childrens Hospital of Philadelphia, used a novel genetics approach integrated with cardiovascular outcomes and lipid data taken fromblood samples from study participants to target specific lipids in the blood. The approach allowed the team to rule out other behavioral or environmental factors that may contribute to heart disease. The results are lending support to existing evidence showing that levels of TG are likely associated with risk of heart disease, while elevated levels of HDLc alone do not provide protection against CHD. These results contribute to our current understanding of which blood lipids cause heart disease and which … Continue reading

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Stem cell therapy – Age reversal1 – Cristal Jan 2014 – Video

Posted: Published on February 11th, 2014

Stem cell therapy - Age reversal1 - Cristal Jan 2014 http://a1stemcells.com/ Cristal, 70 years old. 1 Year after our 1st Age reversal study with stem cells (12 ESC injections in 12 months) For more info: http:/... By: A1 Stem Cells … Continue reading

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StemGenexA Announces Newest Stem Cell Treatment For COPD …

Posted: Published on February 11th, 2014

LA JOLLA, Calif., Feb. 11, 2014 /PRNewswire/ -- StemGenex, the leading resource for adult adipose stem cell therapy in the US aimed at improving the lives of patients dealing with degenerative diseases, today announced the newest therapy to assist patients diagnosed with COPD. COPD affects an estimated 9-10% of the world's entire population and is the 4 th most common cause of death in the United States. StemGenex believes a new therapy delivering adipose derived mesenchymal cells directly to the inflamed lungs may reduce the complications associated with COPD including shortness of breath, coughing, heart problems and more. Direct lung targeting is the latest in a series of newly developed therapies StemGenex has announced over the past few months for patients dealing with degenerative diseases such as Parkinson's, Alzheimer's, Multiple Sclerosis and of course COPD. This targeted therapy is accomplished by nebulizing the stem cells down to a mist so that patients can painlessly breathe the stem cells directly into their lungs. The goal of this new technique is to encourage more stem cells to travel directly to the inflamed tissue of the lungs. Stem cell treatment studies are currently being offered by StemGenex to patients diagnosed with COPD and … Continue reading

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New Live-Cell Printing Technology Works Like Ancient Chinese Woodblocking

Posted: Published on February 11th, 2014

Released: 2/6/2014 12:20 PM EST Embargo expired: 2/10/2014 3:00 PM EST Source Newsroom: Houston Methodist Contact Information Available for logged-in reporters only Newswise HOUSTON -- ( Feb. 6, 2014 ) -- With a nod to 3rd century Chinese woodblock printing and children's rubber stamp toys, researchers in Houston have developed a way to print living cells onto any surface, in virtually any shape. Unlike recent, similar work using inkjet printing approaches, almost all cells survive the process, scientists report in this week's Proceedings of the National Academy of Sciences. The researchers, led by Houston Methodist Research Institute nanomedicine faculty member Lidong Qin, Ph.D., say their approach produces 2-D cell arrays in as little as half an hour, prints the cells as close together as 5 micrometers (most animal cells are 10 to 30 micrometers wide), and allows the use of many different cell types. They've named the technology Block-Cell-Printing, or BloC-Printing. "We feel the current technologies are inadequate," Qin said. "Inkjet-based cell printing leaves many of the cells damaged or dead. We wanted to see if we could invent a tool that helps researchers obtain arrays of cells that are alive and still have full activity." Recent work to print … Continue reading

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UTSA hosts RegenMed conference on stem cell research …

Posted: Published on February 11th, 2014

ATMI - World Stem Cells Regenerative Medicine Congress 2013 We spoke with some of the sponsors at Europe's largest stem cells and regenerative medicine industry conference. This is a three day congress that stages a s... We spoke with some of the sponsors at Europe's largest stem cells and regenerative medicine industry conference. This is a three day congress that stages a s... Why should you attend? Watch the video to find out. Geoff MacKay, Chair, Alliance for Regenerative Medicine (ARM); President & CEO, Organogenesis Inc. The 2013 Stem Cell Meeting on the Mesa was a three-day conference, held October 14-16 in La Jolla, CA, and aimed at bringing together senior members of the regenerative medicine industry with the scientific research community to advance stem cell science into cures. The meeting featured a nationally recognized Scientific Symposium, attended by leading scientists and researchers, in conjunction with the industry's premier annual Regen Med Partnering Forum. Combined, these meetings attracted over 750 attendees from around the globe, fostering key partnerships through one-on-one meetings while also highlighting clinical and commercial progress in the field. CIRM hosted its 2011 Grantee Meeting in San Francisco, bringing together the stem cell scientists and trainees that the … Continue reading

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Many Promising Embryonic Stem Cell Therapies Ensnared In …

Posted: Published on February 11th, 2014

Hey, isn't it great that university scientists are working on making embryonic stem cell therapies? They've done some especially promising work in treating certain causes of blindness, including age-related macular degeneration. But now a strange but serious roadblock has come up. Because of certain federal rules, the majority of embryonic stem cell therapies being studied in universities actually aren't eligible to become sellable treatments, the journal Cell Stem Cell reports. Universities usually do research on U.S. National Institutes of Health-registered embryonic stem cells. However, the NIH's rules don't match up with rules from the U.S. Food and Drug Administration, which would have to approve any embryonic stem cell-based therapy for use the U.S. So these university-created treatments technically aren't allowed to move past the research stage. What a dilemma! Historically, the FDA has allowed clinical trials of therapies created from NIH-registered embryonic stem cells, which suggests the administration knows what's going on and is willing to move stem cell therapies along. So maybe the rules will change in the future. For now, however, they're at an impasse. This is a new problem, brought on by the speed of the advancement of embryonic stem cell research. This is a pretty new … Continue reading

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Two Oncogenes Join to Drive Lung Squamous Cell Carcinoma

Posted: Published on February 11th, 2014

Released: 2/10/2014 12:00 PM EST Source Newsroom: Mayo Clinic Contact Information Available for logged-in reporters only Newswise JACKSONVILLE, Fla. Patients with a common form of lung cancer lung squamous cell carcinoma have very few treatment options. That situation may soon change. A team of cancer biologists at Mayo Clinic in Florida is reporting in the Feb. 10 issue of Cancer Cell the discovery of two oncogenes that work together to sustain a population of cells in lung squamous cell carcinoma, which may be responsible for the lethality of the disease. When these cells, termed cancer stem cells, are inhibited, tumors cannot develop. MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network. Cancer stem cells are a small population of cells in a tumor that can self-renew and grow indefinitely. They resist most treatments and are thought to be responsible for relapse, says the studys senior author, Alan P. Fields, Ph.D., the Monica Flynn Jacoby Professor of Cancer Studies at Mayo Clinic in Florida. If you can shut down cancer stem cells, you may be able to stop relapse after therapy, he says. The study, which is featured on the cover of Cancer Cell, builds … Continue reading

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Body kills spontaneous blood cancers on a daily basis

Posted: Published on February 10th, 2014

Immune cells undergo spontaneous changes on a daily basis that could lead to cancers if not for the diligent surveillance of our immune system, Melbourne scientists have found. The research team from the Walter and Eliza Hall Institute found that the immune system was responsible for eliminating potentially cancerous immune B cells in their early stages, before they developed into B-cell lymphomas (also known as non-Hodgkins lymphomas). The results of the study were published today in the journal Nature Medicine. This immune surveillance accounts for what researchers at the institute call the surprising rarity of B-cell lymphomas in the population, given how often these spontaneous changes occur. The discovery could lead to the development of an early-warning test that identifies patients at high risk of developing B-cell lymphomas, enabling proactive treatment to prevent tumours from growing. Dr Axel Kallies, Associate Professor David Tarlinton, Dr Stephen Nutt and colleagues made the discovery while investigating the development of B-cell lymphomas. Dr Kallies said the discovery provided an answer to why B-cell lymphomas occur in the population less frequently than expected. Each and every one of us has spontaneous mutations in our immune B cells that occur as a result of their normal … Continue reading

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WOSS students rally together to help save woman's life

Posted: Published on February 10th, 2014

Oakville Beaver White Oaks Secondary School (WOSS) students are rallying together to find stem-cell donors to help save a life after being inspired by the story of a 24-year-old woman. Mississaugas Cristina DiCorte was diagnosed with mitochondrial neurogastrointestinal encephalopathy (MNGIE), a rare condition preventing her from being able to digest her own food. DiCorte currently gets all her nutrients through a catheter. A stem-cell transplant could help reduce the effects of MNGIE and prolong and give the woman a better quality of life. WOSS students have teamed up with OneMatch Stem Cell and the Marrow Network to host two swab events this weekend at Oakville Place, in front of Claires, 240 Leighland Ave. The events run Saturday (Feb. 15) from 9:30 a.m.-6 p.m. and Sunday (Feb. 16) from 11 a.m.-5 p.m. There is a special donor registration need for ethnically-diverse males aged 17-35, in good general health. The goal is to add more optimal donors to the OneMatch Network with a simple swab of the inside cheek from donors and a brief health questionnaire. While there are more than 325,000 Canadians currently registered on the OneMatch Network, there are still approximately 1,000 patients searching for a matching stem-cell donor. Currently, … Continue reading

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Stress gives cells a 'second childhood'

Posted: Published on February 10th, 2014

4 hours ago Figure 1: Within a week of exposure to acidic culture conditions, white blood cells gave rise to clusters of cells expressing the pluripotency gene Oct4 (green). Credit: Haruko Obokata, RIKEN Center for Developmental Biology What doesn't kill cells may make them strongeror considerably more flexible, at least. New findings from Haruko Obokata of the RIKEN Center for Developmental Biology in Kobe and Charles Vacanti at Brigham and Women's Hospital in the United States suggest that exposing mouse cells to acidic stress can make them regress to an extremely developmentally immature state, transcending even that of embryonic stem (ES) cells. ES cells have the developmental capacity to form any tissue type in the body and this 'pluripotency' makes them of great interest to both scientists and clinicians. As these cells must be harvested from early-stage embryos, however, human ES cell research remains a politically and ethically fraught issue. As an alternative, researchers can 'reprogram' adult cells into ES cell-like induced pluripotent stem (iPS) cells, which offer the advantage of being genetically matched to their donoran important consideration for regenerative medicine. However, the generation of iPS cells typically requires the introduction of reprogramming genes, which may affect their function … Continue reading

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