The Orthobiologic Institute (TOBI) alumni , Thomas Vangsness Jr M.D., recently published a ground-breaking article examining the intra-articular application of Mesenchymal Stem Cells (MSCs) following partial medial meniscectomy, a common knee surgery where part of the damaged meniscus is removed on the inner portion of the knee joint. This study examined the effects of MSCs on post-operative regeneration of meniscus tissue and changes in Osteoarthritis symptoms. The study consisted of 55 patients who underwent a partial medial meniscectomy, and received one of three different intra-articular kneeinjections 7-10 days post-operatively. Patients received either a high concentration of MSCs, low concentration, or a control. The patients were followed for 2 years and assessed for overall clinical outcomes, meniscal regeneration, and safety.The study revealed significantly increased meniscal volume (>15% increase), quantified via MRI, in both the high concentration and low concentration groups. However, more meniscus growth was seen the low concentration group. No patients in the control group reached the clinically significant 15% increase in meniscal volume. Furthermore, patients with existing osteoarthritis, experienced a reduction in pain compared the control group. This article represents a ground-breaking study in the use of biological cell therapy, also known as Orthobiologics, for post-operative healing and tissue … Continue reading
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