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New stem cell technique may aid medical treatments

Posted: Published on January 29th, 2014

By MALCOLM RITTER/AP Science Writer/January 29, 2014 NEW YORK (AP) A simple lab treatment can turn ordinary cells from mice into stem cells, according to a surprising study that hints at a possible new way to grow tissue for treating illnesses like diabetes and Parkinsons disease. Researchers in Boston and Japan exposed cells from spleens of newborn mice to a more acidic environment that theyre used to. In lab tests, that turned them into stem cells, showing enough versatility to produce the tissues of a mouse embryo, for example. Cells from skin, muscle, fat and other tissue of newborn mice appeared to go through the same change, which could be triggered by exposing cells to any of a variety of stressful situations, researchers said. Scientists hope to harness stem cells to replace defective tissue in a wide variety of diseases. By making stem cells from the patient, they can get around the problem of transplant rejection. Human cells are now routinely turned into so-called iPS stem cells. That involves reprogramming an ordinary cell by slipping genes or substances into its nucleus. The new method, in contrast, lets the cell change its own behavior after researchers have applied an external stress. … Continue reading →

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£4.5million awarded to 10-year-old girl who suffered ‘catastrophic’ brain injury at birth

Posted: Published on January 29th, 2014

Samantha Singleton-Parkes suffered the injuries soon after birth because of mistakes in her care A 10-year-old girl is to receive a 4.5million compensation payout after she suffered a catastrophic brain injury shortly after she was born The damages, made up of a lump sum and annual payments, will provide a more secure financial future for Samantha Singleton-Parkes, who has cerebral palsy, and comfort and reassurance for her mother Gail, London's High Court heard today. The settlement against Colchester Hospital University NHS Foundation Trust in Essex was approved by Judge Birtles, who was told by David Pittaway QC that Samantha's family had played a fantastic part in bringing her up. Solicitor Julian Wilson, of law firm Thompson Smith and Puxon, said later: "In the vast majority of cases medical treatment in this country is carried out very competently. "However, in Samantha's case, mistakes were made following her birth which led to a catastrophic brain injury. "Samantha's mother's main concern in this litigation has always been to secure Samantha's future, and this settlement achieves that." The hospital trust denied liability for negligence but agreed to pay 70 per cent of the damages that Mrs Singleton-Parkes was claiming in the High Court. Mrs … Continue reading →

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Early rehabilitation important for recovery after severe traumatic brain injury

Posted: Published on January 29th, 2014

PUBLIC RELEASE DATE: 28-Jan-2014 Contact: Krister Svahn krister.svahn@sahlgrenska.gu.se 031-786-3869 University of Gothenburg Early rehabilitation interventions seem to be essential for how well a patient recovers after a severe brain injury. It might even increase the chances for long-term survival, according to researchers at the Sahlgrenska Academy. In a series of studies, Trandur Ulfarsson, doctoral student at the Sahlgrenska Academy, University of Gothenburg, has explored the long-term effects of traumatic brain injuries caused for example by accidents or violence. The studies, where 280 Swedish and Icelandic participants were followed up 1-11 years after the injury, show a clear association between how quickly patients get access to rehabilitation and how well they recover. Functional activity improved 'We found that the functional activity for example how independent the patients are in their daily activities and how fast they can return to work is substantially improved among those who are admitted to inpatient rehabilitation care early,' says Ulfarsson, who presents the results in his doctoral thesis. The studies also show that severe brain injury often leads to an impaired pituitary function, most often lack of growth hormone, which in turn may cause obesity. Being unemployed or on sick leave prior to the injury also … Continue reading →

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The talk – getting the conversation started about advance directives

Posted: Published on January 29th, 2014

I had the privilege to work as a palliative care nurse practitioner in a large hospital with nine different intensive care units. One morning an order for palliative care was received from a trauma surgeon for a 67-year-old female patient with a traumatic brain injury and very poor prognosis. As a palliative care nurse practitioner it was my job to go to the ICU, review the patients chart, speak with the trauma surgeon, nursing and case manager, examine the patient for any symptom management needs, and contact the family to set up a meeting. In the family meeting we would discuss the patients condition, treatment options, advance directives, and patients prognosis. This particular case included the patient, her husband, four children, and eight grandchildren. The patient was a retired nurse, working as a volunteer for the Red Cross on a mobile unit for a blood drive in the community. She was exiting a bus mobile unit, and somehow lost her balance. She fell down the stairs of the bus and out the door head first onto the concrete curb, sustaining a major head injury. She was rushed to our hospital, where a MRI indicated a massive brain bleed, she was … Continue reading →

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Doctors say no brain activity, family refuses to give up

Posted: Published on January 29th, 2014

Topics: brain dead, brain tumour, coma, jamie manuele, rockhampton hospital AS Rockhampton's Daphnejean Finnegan strokes the head of her son, she knows one of the toughest decisions of her life is coming. Daphnejean is living every mother's worst nightmare. Her son Jamie Manuele has been stuck in a hospital bed since August, after he suffered swelling to his brain. After months of tending to his every need, she now has three options for Jamie's future. Daphnejean said she had been told by doctors that Jamie is brain-dead, leaving her with the options to transfer him to a brain injury centre in Brisbane, pay to keep him in a room in the Rockhampton Hospital, or take him home. She said she could not bear to send her son away to Brisbane, but the family could not afford the long-term cost of keeping him in the Rockhampton Hospital. In an ideal world, Daphnejean would bring her son home and care for him, but she does not have the equipment or training to go down that path just yet. Jamie still needs feeding tubes in hospital. But Daphnejean won't let doctors tell her that Jamie has no brain activity. Original post: Doctors say … Continue reading →

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Biogen Profit Jumps on MS Treatment Revenue

Posted: Published on January 29th, 2014

By Dow Jones Business News, January 29, 2014, 07:08:00 AM EDT By Ben Fox Rubin Biogen Idec Inc. ( BIIB ) on Wednesday said its fourth-quarter profit grew 57%, as sales of its multiple-sclerosis treatment Tecfidera continued to boost the biotechnology company's revenue. For the new year, the company projected adjusted earnings of $11.00 to $11.20 a share and revenue growth of 22% to 25% . Analysts polled by Thomson Reuters expected $11.63 a share in profit and revenue growth of 21%. Biogen recently launched Tecfidera, a pill for multiple sclerosis that analysts expect to steal significant market share from the injectable drugs that now dominate the market. The drug has had brisk early adoption from patients seeking easier-to-take drugs, despite having been approved after two rival oral drugs made by Biogen competitors. Biogen is aiming to become the dominant maker of MS treatments, a group of drugs that command high prices and that patients typically take for years. The company reported a profit of $457.3 million, or $1.92 a share, up from $292.1 million, or $1.23 a share, a year earlier. Excluding amortization and other items, per-share earnings grew to $2.34 from $1.40. Revenue jumped 39% to $1.97 billion. … Continue reading →

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Natural Multiple Sclerosis Treatment Review Reveals the Inside Story to Remarkable MS Cure

Posted: Published on January 29th, 2014

Denver, Colorado (PRWEB) January 28, 2014 Daily Gossip Magazine reveals in its Natural Multiple Sclerosis Treatment review that this program was actually created by Dr. Gary M Levin, an appreciated surgeon and health expert. To read more about Dr. Gary M. Levin's natural treatment for Multiple sclerosis visit the official website at: http://www.dailygossip.org/natural-multiple-sclerosis-treatment-review-7356 Levin says that even though multiple sclerosis can be a very discouraging condition, patients should know that a cure can be achieved for this disease. According to the author of Natural Multiple Sclerosis program, the reason why doctors cannot cure multiple sclerosis is actually linked to the fact that they dont understand the real cause of the disease. Dr. Gary claims that multiple sclerosis is in fact an autoimmune condition, caused by the overactive immune system. According to the Natural Multiple Sclerosis Treatment review, Gary Levin goes further to explain that the overactive immune system actually is the real problem that sufferers need to deal with in order to achieve a cure. Levins method to cure multiple sclerosis is detailed by the author in his guide, which naturally focuses on eliminating the cause of the disease. Levin says that strengthening the immune system will help sufferers improve … Continue reading →

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Opexa Therapeutics to Present at the 16th Annual BIO CEO & Investor Conference

Posted: Published on January 29th, 2014

Opexa Therapeutics, Inc. (NASDAQ: OPXA), a biotechnology company developing Tcelna, a novel T-cell immunotherapy for the treatment of multiple sclerosis (MS), today announced that Neil K. Warma, President and Chief Executive Officer, will present at the 16th Annual BIO CEO & Investor Conference on Monday, February 10, 2014, at 11:30 a.m. EST in the Conrad Room. The conference will be held at the Waldorf=Astoria Hotel in New York, NY. A live webcast of the company presentation can be accessed here, or via the Investor Relations section of the Companys website at http://www.opexatherapeutics.com. An archive of the webcast will be available on the Company's website until May 11, 2014. About Opexa Opexas mission is to lead the field of Precision Immunotherapy by aligning the interests of patients, employees and shareholders. The Companys leading therapy candidate, Tcelna, is a personalized T-cell immunotherapy that is in a Phase IIb clinical development program (the Abili-T trial) for the treatment of SPMS. Tcelna is derived from T-cells isolated from a patients peripheral blood, expanded ex vivo, and reintroduced into the patient via subcutaneous injections. This process triggers a potent immune response against specific subsets of autoreactive T-cells known to attack myelin. About Multiple Sclerosis (MS) … Continue reading →

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Foodborne toxin could trigger MS, studies suggest

Posted: Published on January 29th, 2014

Health JoNel Aleccia NBC News 18 hours ago CDC / CDC Toxins produced by Clostridium perfringens, a common cause of foodborne illness, could be a potential trigger for multiple sclerosis, scientists say. Add another clue to the mystery of multiple sclerosis: Scientists say a poison produced by common foodborne germs could be a trigger for the debilitating autoimmune disorder that affects 400,000 Americans. Researchers at Weill Cornell Medical College in New York have discovered that a toxin made by the bacterium Clostridium perfringens responsible for a million cases of food poisoning in the U.S. each year appears to attack the cells associated with MS. What weve shown is the toxins target the cells that are targeted in MS, said Jennifer Linden, a Weill Cornell researcher whos presenting findings Tuesday at a meeting of the American Society for Microbiology. Her research also showed that about 13 percent of a small sample of food products harbored C. perfringens bacteria, and nearly 3 percent were positive for the toxin linked to MS. Its too early to suggest that MS is caused by food poisoning, but it does raise the possibility that the C. perfringens bacteria could be involved in activating the disease, said … Continue reading →

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Woman (48) wins European case over school abuse

Posted: Published on January 29th, 2014

The European Court of Human Rights has ruled in favour of Irish woman Louise OKeeffe in her landmark case against the Irish State, ruling that the Irish state failed to meet its obligation to protect Ms OKeeffe from the sexual abuse she suffered while a pupil in an Irish national school. Suzanne Lynch, Barry Roche Irish woman Louise OKeeffe, who today won a landmark case against the Irish State, said the ruling meant the Department of Education must protect children in schools. The European Court of Human Rights ruled this morning that the State had failed to meet its obligation to protect Ms OKeeffe from the sexual abuse she suffered while a pupil in an Irish national school. Ms O Keeffe had brought her case to the European Court after the Irish Supreme court ruled in 2009 that the State was not legally liable for the abuse suffered by Ms OKeeffe by her school principal while a nine-year old girl at Dunderrow National School. Speaking from Cork after the ruling Ms OKeeffe said: The message I have today for the Department of Education on foot of this ruling is that you must protect children in the schools, its a right … Continue reading →

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