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California to fund research in stem-cell genomics

Posted: Published on January 28th, 2014

SACRAMENTO, Calif. (AP) The state of California is preparing to invest up to $40 million in a new scientific field that backers say could revolutionize medicine and lead to personalized medical treatments. The directors of the California Institute for Regenerative Medicine are meeting in Berkeley this Wednesday to create one or two research centers for stem-cell genomics, the Sacramento Bee (http://bit.ly/1mKZTRp) reported Sunday. Scientists and biotech companies in the San Francisco Bay Area, San Diego and elsewhere are competing for the research money. Researchers believe that genomics, the study of genes and their relationships, can lead to more effective therapies that are tailored to a patient's genetic makeup. The new research centers for stem-cell genomics could help make California a leader in the fast-moving field. "Right now, in a lot of ways, doctors are making educated guesses as to how to treat us patients more generally," said UC Davis stem cell researcher Paul Knoepfler. "By knowing our genomic information ... they could be making far more educated choices about treatments." The move into genomics comes as the California Institute for Regenerative Medicine struggles to fulfill the promises of the 2004 ballot initiative campaign that created the $3 billion stem-cell agency. … Continue reading →

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Q&A – Stem cells could offer treatment for a myriad of diseases

Posted: Published on January 28th, 2014

Q&A - Stem cells could offer treatment for a myriad of diseases Tuesday, January 28, 2014 Q.What are stem cells? Stem cells are different however as they are at an earlier stage in cell development and this means they can make more cells and transform into different cell types such as a skin stem cell can make all the different types of skin cells. Q. And there are two types? A.Yes. There are two types of stem cells: embryonic stem cells and adult stem cells. Embryonic stem cells can generate all cells of the human body. Adult stem calls generate a more limited number of human cell types. Q.Why are stem cells so important? A.For many years, adult stem cells have been used to treat rare blood and certain cancers. However, adult stem cells cant generate all cell types. For example, scientists say there doesnt appear to be an adult stem cell that can make insulin- secreting cells of the pancreas. Embryonic stem cells can, however, as they can generate all cell types and the aim of scientists is to use these embryonic cells to generate healthy tissue to replace cells compromised by disease. This means that embryonic cells are … Continue reading →

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Osiris Therapeutics, Inc. (OSIR): New Analyst Report from Zacks Equity Research – Zacks Equity Research Report

Posted: Published on January 27th, 2014

Summary: Osiris reported break-even earnings in the third quarter of 2013, well above the Zacks Consensus Estimate of a loss of $0.09 and the year-ago loss of a penny per share. Revenues for the quarter came in at $6.9 million, in line with the Zacks Consensus Estimate and above the year-ago revenues of $2.2 million. In early Oct 2013, Osiris sold its culture-expanded mesenchymal stem cell (ceMSC) business including Prochymal to a wholly-owned subsidiary of Mesoblast Limited. This deal has not only brought in cash for Osiris in the form of an upfront payment, the company will also be entitled to royalty payments. We are moving back to a Neutral recommendation as we believe the current price reflects the afore-mentioned positive developments. Overview: Columbia, Md.-based Osiris Therapeutics, Inc. focuses on the development, manufacture and sale of biologic products which have been developed to promote the body's natural healing process and improve surgical outcomes. Currently marketed products include Grafix, Ovation, OvationOS and Cartiform for tissue repair. In Oct 2013, Osiris sold off its culture-expanded mesenchymal stem cell (ceMSC) business including Prochymal to a wholly-owned subsidiary of Mesoblast Limited for up to $100 million. Osiris will also be entitled to receive single … Continue reading →

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Stem cells lab to open in Galway

Posted: Published on January 27th, 2014

Published Monday, 27 January 2014 A young teenager with diabetes tests his blood levels. (UTV) Scientists behind the new facility at the National University of Ireland Galway will aim to produce adult cells to combat conditions like diabetes, arthritis and heart disease. Stem cells created at the lab will be used in clinical trials following regulatory approval - the first of which is to test their effects on critical limb ischemia, a common complication associated with diabetes which often results in amputation. The cells, mesenchymal stem cells (MSCs), will undergo safety tests after being isolated from bone marrow from donors and grown in the laboratory to generate sufficient quantities. The university said it will position it as a global player in regenerative medicine. NUI Galway's Centre for Cell Manufacturing Ireland is the first facility on the island of Ireland to receive a licence from the Irish Medicines Board to manufacture culture-expanded stem cells for human use. It is one of less than half a dozen in Europe authorised for the process. Some 70% of pharmaceutical companies have regenerative medicine therapies in development, with 575 active trials in cell and gene therapy under way. There are more than 1,900 cell therapy … Continue reading →

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Ireland university lab in stem cells move

Posted: Published on January 27th, 2014

AAP Scientists in Ireland aim to produce adult cells to combat conditions like arthritis. Stem cells for human use are to be made in a university lab in the first medical program of its kind in Ireland. Scientists behind the new facility at the National University of Ireland (NUI) Galway will aim to produce adult cells to combat conditions like arthritis, heart disease and diabetes. Stem cells created at the lab will be used in clinical trials following regulatory approval - the first of which is to test their effects on critical limb ischemia, a common complication associated with diabetes which often results in amputation. The cells, mesenchymal stem cells (MSCs), will undergo safety tests after being isolated from bone marrow from donors and grown in the laboratory to generate sufficient quantities. The university said it will position it as a global player in regenerative medicine. NUI Galway's Centre for Cell Manufacturing Ireland is the first facility in Ireland to receive a licence from the Irish Medicines Board to manufacture culture-expanded stem cells for human use. And it is one of less than half a dozen in Europe authorised for the process. "Developing Galway's role as med-tech hub of global … Continue reading →

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Galway stem cell lab to be used in fight against heart disease and diabetes

Posted: Published on January 27th, 2014

27/01/2014 - 09:35:51Back to Ireland Home Stem cells for human use are to be made in a university lab in the first medical programme of its kind in Ireland. Scientists behind the new facility at the National University of Ireland Galway will aim to produce adult cells to combat conditions like arthritis, heart disease and diabetes. Stem cells created at the lab will be used in clinical trials following regulatory approval the first of which is to test their effects on critical limb ischemia, a common complication associated with diabetes which often results in amputation. The cells, mesenchymal stem cells (MSCs), will undergo safety tests after being isolated from bone marrow from donors and grown in the laboratory to generate sufficient quantities. The university said it will position it as a global player in regenerative medicine. NUI Galways Centre for Cell Manufacturing Ireland is the first facility on the island of Ireland to receive a licence from the Irish Medicines Board to manufacture culture-expanded stem cells for human use. And it is one of less than half a dozen in Europe authorised for the process. President of NUI Galway Dr Jim Browne said: Developing Galways role as med-tech hub of … Continue reading →

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Cerebral Palsy sufferer Lola Stockdale needs Sittingbourne residents’ help to raise funds

Posted: Published on January 27th, 2014

The clock is ticking to raise 50,000 so a disabled girl can undergo pioneering surgery in the US. Six-year-old Lola Stockdale has four limb cerebral palsy, global development delay and cerebral vision problems caused by birth trauma. Her condition means she is unable to walk, talk or feed herself. She relies on a wheelchair to get around and wears glasses. Bungee jumper Anthony Lewis raised money for Lola Stockdale. In a bid to improve her quality of life, parents Kellie Humphrey, 34, and Noel Stockdale, 36, started a campaign called Lolas Journey in August 2012 to raise the necessary funds so their daughter can undergo stem cell treatment in America. It is hoped the operation, which involves taking cells and implanting them into the brain to act as a repair system, will improve her quality of life. The couple will cover the flight and accommodation costs themselves. So far they have raised 30,700 thanks to various fundraisers, donations and sponsored events, but the final target needs to be raised before July so the youngster can be treated the following month. Mum-of-three Kellie, a former Westlands School student whose parents live in Harold Road, Sittingbourne, said: What weve raised so far … Continue reading →

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CSUN student rides of Rose Parade float after overcoming cerebral palsy

Posted: Published on January 27th, 2014

Published on January 27, 2014 By Araceli Castillo Precious Malumfashi, 26, shows the pin she received for participating on the Festival of Roses Parade on Jan. 1. Photo credit by Trevor Stamp. CSUN communications student Precious Malumfashi, 26, was not only born premature at 24 weeks, but was diagnosed with cerebral palsy disorder soon thereafter. Malumfashi was kept in an incubator and stayed hospitalized for three months at a Kaiser Permanente hospital in Woodland Hills. It was unknown what condition she had until she was 2 years old. Cerebral palsy: a disorder that affects the nervous system and is not genetic. Sometimes seen in premature babies it is caused by the lack of oxygen reaching the brain. The disorder has affected Malumfashis ability to walk from a very young age. Malumfashi has inspired and helped others by sharing her story. I dont have a disability I have a handi-capability, Malumfashi said. I can do anything anybody else can do. I just do it differently. Malumfashis mother, Lori Malumfashi, was given little hope on the condition of her daughter. Doctors could not predict how Malumfashi would be the next day and instead fought hour by hour to keep her alive. Three … Continue reading →

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For injured veteran, war continues even at home

Posted: Published on January 27th, 2014

By Elizabeth Simpson The Virginian-Pilot January 27, 2014 HAMPTON Chuck Rotenberry can talk about the virtues of others, both man and dog, at length. The Marines he served with during two deployments, Iraq in 2005 and Afghanistan in 2011. How young they were. How eager. "To see what these Marines go through ... they were hungry for it every day. Each day, they wake up not knowing if they're coming back, but they do it." And the dogs - they go first when clearing an area of improvised explosive devices or checking a house during a forced entry. It's something most people back home don't stop to think about: who walks point. "Everyone is looking at the dog and the dog handler like, 'Whaddaya got?' That's a huge responsibility." But Chuck, 35, is slower to talk about himself. Active-duty Marine for 13 years. A staff sergeant, chief trainer of military dogs and kennel master. Now a Marine reservist living in Hampton. It takes awhile to get to the part about the IED, the shrapnel, the flying body parts, the brain injury. Originally posted here: For injured veteran, war continues even at home … Continue reading →

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The Devastating Consequences of Traumatic Brain Injury

Posted: Published on January 27th, 2014

Personal injury attorneys often represent clients who suffer from traumatic brain injury, or TBI. In the U.S., approximately 1.6 million people sustain a TBI each year, with 50,000 of those dying and 125,000 disabled within one year. Traumatic brain injury results from sudden trauma that disrupts brain function. The trauma can occur when the head suddenly and violently hits an object, or when an object pierces the skull and damages brain tissue. TBI is the number one cause of mortality and disability in young adults, and the severity of the injury is determined by the nature, speed, and location of the impact. Symptoms of Traumatic Brain Injury Persons with mild, moderate, or severe traumatic brain injury often exhibit the same symptoms, although there are some indications that are unique to one or the other. Someone with mild TBI may experience a loss of consciousness and remain unconscious for a few seconds or minutes. The symptoms of moderate TBI are similar but usually more serious and long lasting. Some common symptoms of both include headache, confusion, dizziness, blurred vision, fatigue, and behavioral or mood changes. A person with severe TBI may remain unconscious for 24 hours or more, and frequently exhibits … Continue reading →

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