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PTC Therapeutics muscular disorder drug turned down by EU

Posted: Published on January 25th, 2014

January 24, 2014 7:54 am by Staff | 0 Comments MedCity News (Reuters) - PTC Therapeutics Inc said a committee of the European Medicines Agency did not recommend conditional approval of its drug for the treatment of a rare muscular disorder, sending its shares down as much as 28 percent in premarket trading. The company said it intends to request the committee for a re-examination. It was seeking a so-called conditional approval, granted to treatments that show early benefit. The drugmaker still needs to conduct trials. The drug, ataluren, is intended to treat a form of Duchenne muscular dystrophy which occurs due to a type of genetic mutation known as a nonsense mutation. PTC Therapeutics joins a list of companies struggling with regulatory setbacks to their Duchenne muscular dystrophy drug programs. Sarepta Therapeutics Inc and Prosensa Holding NV recently faced U.S. regulatory setbacks. PTC Therapeutics shares closed at $26.22 on Thursday on the Nasdaq. Get our daily newsletter or follow us. Please enter your email below: Read more from the original source: PTC Therapeutics muscular disorder drug turned down by EU … Continue reading

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Autism diagnosis change ‘results in loss of treatment’

Posted: Published on January 25th, 2014

When the criteria for diagnosing autism were changed last year, concerns were raised that people already diagnosed might be re-evaluated and end up losing access to treatments and services. The American Psychiatric Association (APA), which publishes the diagnostic guidelines, recommends that children who are receiving appropriate treatment as the result of the old criteria should not be required to undergo a re-examination with the new criteria by insurance companies. But a small survey revealed to New Scientist suggests that not everyone is following the party line. In May, the APA published the DSM-5, the latest edition of what has come to be known as psychiatry's diagnostic bible. One controversial change was to the criteria used to diagnose different kinds of autism, which are now combined under the umbrella term of "Autism Spectrum Disorder" (ASD). Under the previous criteria of DSM-4, a person would be diagnosed with ASD by exhibiting at least six of 12 behaviours, which include problems with communication, interaction and repetition. Now, that same person would need to exhibit three deficits in social communication and interaction and at least two repetitive behaviours the latter, say critics, makes the new criteria more restrictive. To see how the change in … Continue reading

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Councillor returns home after stroke

Posted: Published on January 25th, 2014

Miracle number one was that I had my lifejacket on, said McNaughton, who likes to fish from his kayak. I happened to be on shore, but I hadnt bothered to take it off. He had promised his wife Arlette Raaen that he would wear his lifejacket whenever near the water fishing. As the stroke hit, McNaughton dove headfirst into the water. A person who regularly fishes in the area and knows McNaughton saw him go into the water and ran over to assist him. After he had recovered somewhat, Raaen told him how shocked the man was to see McNaughton dive in the water at that moment. He said I knew that Chris is a real avid fisherman, but when he went teeth-first for the fish I thought that was a little overboard, recounted McNaughton. While in the water, he did not realize what was happening to him but remembers thinking about the effect drinking so much saltwater was going to have on his digestion. Little did I know, he added. BC Ambulance Service and Malaspina Volunteer Fire Department came to McNaughtons aid and he was taken to Powell River General Hospital (PRGH). Miracle number two was the fact that … Continue reading

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New trial offers new hope for those with spinal cord injuries

Posted: Published on January 25th, 2014

CALGARY- A Winnipeg paramedic has become the first Canadian to take part in an international clinical trial involving the treatment of spinal cord injuries using stem cells. Alex Petric was injured last year during a winter vacation in Panama. I misjudged the water and just dove in, the 29-year-old recalls. I hit shallow water and became paralyzed immediately. Petric, now a paraplegic, became involved with the trial just four months after his injury. Its a phase one trial which means that its looking at the safety and tolerability of the procedure, explains Dr. Steve Casha, medical team lead for the University of Calgary. A Swiss company, calledStem Cells Incorporatedis the driving force behind the research. A team in Switzerland has already treated eight other spinal cord patients. During the trial, researchers must first identify the precise location of Petrics spinal cord injury. Then, stem cells are injected into two sites above and two sites below the injury to hopefully recreate lost tissue. What these cells will hopefully do, and what they seem to do from previous clinical studies is take up residence in the spinal cord. They are a self-renewing population and they can differentiate or become various cells, Dr. … Continue reading

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Local firm Banyan will be in on NFL concussion research

Posted: Published on January 25th, 2014

Published: Friday, January 24, 2014 at 6:07 p.m. Last Modified: Friday, January 24, 2014 at 6:07 p.m. University of Florida athletes who suffer head injuries will immediately be given a blood test that shows the severity of a possible brain injury under research funded by the NFL and GE to improve the diagnosis and treatment of concussions. Banyan Biomarkers, an Alachua-based company that makes a blood test for traumatic brain injury, was one of 16 companies to receive $300,000 through the NFL and GEs Head Health Challenge. Six companies, including Banyan Biomarkers, could be eligible for an additional $500,000 in 2015. Banyan Biomarkers will work with Dr. Jay Clugston, a physician for UF teams, and other UF researchers to do finger-stick blood draws on consenting UF football, womens soccer and womens lacrosse players, according to a news release from UF. The blood tests will be compared with magnetic resonance imaging findings. The goal is to create a test to diagnose brain injuries within 30 minutes to determine whether a player should return to the game. Not only does an injured player sometimes appear to be fine, but he or she may try to conceal symptoms in their competitive zeal to … Continue reading

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Bragg military brain injury center breaks ground Friday

Posted: Published on January 25th, 2014

FORT BRAGG, N.C. Fort Bragg personnel on Friday celebrated the groundbreaking of a new center to research, diagnose and treat brain injury and post-traumatic stress disorder for military men and women. The Fort Bragg Intrepid Spirit Center is the fourth center of its type in the nation. Fort Braggs commander, Lt. Gen. Joseph Anderson, said the horrors of war speak for themselves, but many other factors can contribute to PTSD in service members. Many complicating factorscan contribute to how you get it, he said. And then the question becomes the challenges of helping them heal, recover. Traumatic brain injury and post-traumatic stress is a different kind of wound, said Arnold Fisher with the Intrepid Fallen Heroes Fund. Its unseen. Apparently, because its unseen, very many people dont understand it. Anderson said he expects the center to treat more than 1,000 soldiers a year. Doctors are finding new ways to treat PTSD and other brain-related illnesses and injuries. Sleep is critical to healing, said James Kelly, director of the National Intrepid Center of Excellence. We do sleep analysis, overnight sleep studies on every single patient. And were finding that targeting that particular problem for them really turns around a lot of … Continue reading

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Diabetes: Progress toward stem cell therapies – Video

Posted: Published on January 25th, 2014

Diabetes: Progress toward stem cell therapies California's Stem Cell Agency (CIRM) hosted a live Google Hangout about recent progress in stem cell based strategies for diabetes therapies. The speakers in... By: California Institute for Regenerative Medicine … Continue reading

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Happy Valley Animal Hospital of Arizona Pet Vet Helps a Local Pet Start the New Year with the Resolution; Play More

Posted: Published on January 25th, 2014

Glendale, Arizona (PRWEB) January 24, 2014 Floppy, a nine year old Dachshund, struggled to get up from a laying position before his recent stem cell therapy at Happy Valley Animal Hospital. The pain from arthritis was so bad he was reluctant to move much at all, even when encouraged by his family. This holiday season Floppys owners gifted him with quality of life. Now hes bringing in the New Year with less pain and more ability to run and play again. Floppy had been suffering from osteoarthritis in his hips and knees long enough that it was affecting other joints in his hind end. He had difficulty getting up after sitting, limped, and exhibited stiffness. Happy Valley Animal Hospitals Dr. Victor Saltzman determined Floppy was a great candidate for stem cell therapy using Vet-Stem services, and in early December scheduled Floppy for a small fat tissue collection to start the process. Floppys fat was overnighted to Vet-Stems lab in San Diego, California where it was processed into injectable doses of Floppys own stem cells. In 48 hours Dr. Saltzman received the doses back and had started Floppy on his way to recovery. We are extremely pleased with the results. The … Continue reading

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New clues may link hereditary cancer genes to increased risk of cancer from alcohol

Posted: Published on January 24th, 2014

PUBLIC RELEASE DATE: 23-Jan-2014 Contact: Vanessa Wasta wasta@jhmi.edu 410-614-2916 Johns Hopkins Medicine In laboratory experiments conducted on human cell lines at the Johns Hopkins Kimmel Cancer Center, scientists have shown that people carrying certain mutations in two hereditary cancer genes, BRCA2 and PALB2, may have a higher than usual susceptibility to DNA damage caused by a byproduct of alcohol, called acetaldehyde. The scientists say they suspect that the two genes in their normal forms evolved to protect cells against the damaging effects of acetaldehyde, which can lead to cancer. While the scientists caution that the research is preliminary, they say their findings suggest that studies on disease risk factors should take into account these particular genetic variations and the use of alcohol. "We need to identify which behaviors in certain populations increase disease risk, and keep in mind that our genetic susceptibility plays a large role in cancer risk," says Scott Kern, M.D ., the Everett and Marjorie Kovler Professor in Pancreas Cancer Research at Johns Hopkins. Acetaldehyde (pronounced ah-set-AL-deh-hide) is produced during the metabolism of alcohol and is known to cause DNA damage. Scientists say the chemical is ubiquitous in nature, found in many sources, including apples and gut … Continue reading

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San Francisco surrenders in fight over cell-phone warnings

Posted: Published on January 24th, 2014

By Steve Gorman, Scott Malone and Nick Zieminski, Reuters San Francisco city leaders, after losing a key round in court against the cell phone industry, have agreed to revoke an ordinance that would have been the first in the United States to require retailers to warn consumers about potentially dangerous radiation levels. In a move watched by other U.S. states and cities considering similar measures, the city Board of Supervisors voted on Tuesday to settle a lawsuit with the Cellular Telecommunications Industry Association by accepting a permanent injunction against the right-to-know cell phone ordinance. The group had alleged the law violated its free-speech rights, and the settlement marked a victory for the industry as the Federal Communications Commission considers a reassessment of safe radiation exposure limits adopted in 1996. "This is just a terrible blow to public health," Ellen Marks, an advocate for the measure, said outside the supervisors' chambers. She said her husband suffers from a brain tumor on the same side of his head to which he most often held his mobile phone. The industry association has asserted the San Francisco ordinance, if put into effect, would mislead consumers about the relative risks posed by cell phones, contrary … Continue reading

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