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Scientists find estrogen promotes blood-forming stem cell function

Posted: Published on January 24th, 2014

Jan. 22, 2014 Scientists have known for years that stem cells in male and female sexual organs are regulated differently by their respective hormones. In a surprising discovery, researchers at the Children's Medical Center Research Institute at UT Southwestern (CRI) and Baylor College of Medicine have found that stem cells in the blood-forming system -- which is similar in both sexes -- also are regulated differently by hormones, with estrogen proving to be an especially prolific promoter of stem cell self-renewal. The research, published in Nature, raises several intriguing possibilities for further investigation that might lead to improved treatments for blood cancers and increased safety and effectiveness of chemotherapy. Before the finding, blood-forming stem cells were thought to be regulated similarly in both males and females, according to the paper's senior author, Dr. Sean Morrison, Director of CRI, Professor of Pediatrics, and the Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center. However, while working in Dr. Morrison's laboratory as postdoctoral fellows, Dr. Daisuke Nakada, the first and co-corresponding author of the study, and Dr. Hideyuki Oguro discovered that blood-forming stem cells divide more frequently in females than in males due to higher estrogen levels. The research, … Continue reading →

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HIGGS BOSON – Video

Posted: Published on January 24th, 2014

HIGGS BOSON Painter, Eva Montealegre, and her painting: HIGGS BOSON, Portrait of the First Woman, 64" x 100" inspired by the Peter Higgs creation theory and a live 3-D e... By: Eva Montealegre … Continue reading →

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Insulin-producing beta cells from stem cells: Scientists decipher early molecular mechanisms of differentiation

Posted: Published on January 24th, 2014

Jan 23, 2014 Endodermal cells, they form organs such as lung, liver and pancreas. Credit: IDR, Helmholtz Zentrum Mnchen The Wnt/-catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells. These are organized in germ layers and are thus the origin of different tissue types, including the pancreas and its insulin-producing beta cells. With these findings, Helmholtz Zentrum Mnchen scientists have discovered key molecular functions of stem cell differentiation which could be used for beta cell replacement therapy in diabetes. The results of the two studies were published in the renowned journal Development. The findings of the scientists of the Institute of Diabetes and Regeneration Research (IDR) at Helmholtz Zentrum Mnchen (HMGU) provide new insights into the molecular regulation of stem cell differentiation. These results reveal important target structures for regenerative therapy approaches to chronic diseases such as diabetes. During embryonic development, organ-specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body. The pluripotent cells of the embryo organize themselves at an early stage in germ layers: the endoderm, mesoderm and ectoderm. From these three cell populations different functional tissue cells arise, such … Continue reading →

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Evidence rapidly building on utility of ultrasound in areas other than cardiology

Posted: Published on January 24th, 2014

PUBLIC RELEASE DATE: 23-Jan-2014 Contact: Bret P. Nelson bret.nelson@mssm.edu 212-241-6794 World Heart Federation A paper in this month's edition of Global Heart (the journal of the World Heart Federation) says there is mounting evidence regarding the utility of ultrasound in areas outside its traditional field of cardiology, with increasing use reported in general hospital wards, clinics, and even pre-hospital environments. The paper is by Associate Professor Bret Nelson and Dr Amy Sanghvi of Mount Sinai School of Medicine, New York, USA. "The pervasive use of focused ultrasound is perhaps most evident in the advent of ultrasound training in undergraduate medical curricula," say the authors. They refer to a 2011 review paper that highlighted the growing use of point-of-care ultrasound by clinicians in over 20 specialties. "Increased training by clinicians across many specialties, coupled with technology improvements yielding lower cost and better quality studies, have contributed to this trend," they add. In emergency medicine, as well as yielding more rapid and accurate diagnoses in most cases compared with physical examinations alone, the authors say that the prognostic value of emergency physician-performed cardiac ultrasound has been demonstrated. Several studies have shown that no cardiac arrest patients without cardiac activity evident on ultrasound … Continue reading →

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Bioquark Inc. Appoints Dr. Joel I. Osorio MD, Specialist in Functional Anti-Aging Regenerative and Stem Cell Medicine …

Posted: Published on January 23rd, 2014

Philadelphia, PA (PRWEB) January 23, 2014 Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of combinatorial biologics for regeneration and disease reversion in human organs and tissues, today announces the appointment of Dr. Joel I. Osorio MD, as VP of International Clinical Development. We are honored to have someone with Dr. Osorios experience join us as we execute on a globalized clinical strategy, said Ira S. Pastor, CEO, Bioquark Inc. His broad clinical experience in functional anti-aging regenerative and stem cell based medicine make him a very valuable addition to the Bioquark team. Dr. Osorio brings over 9 years of experience in medical practice, both in the private practice and public medical settings. Currently the medical director of the medical spa Bamboo Rejuvenecimiento Facial y Coporal (http://www.bamboobelleza.com), Dr. Osorio has served in capacities in both private and public practice, as a hospital staff physician, and as emergency health services coordinator for a variety of private and public institutions throughout Mexico. He earned MD degrees at both Westhill University and the National Autonomous University of Mexico as a medical surgeon, has diplomas in aesthetic medicine from the Autonomous University of Guadalajara, is an Advance Fellow by the American Board of … Continue reading →

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stem cell therapy treatment for cerebral palsy sri lanka by dr alok sharma, mumbai, india – Video

Posted: Published on January 23rd, 2014

stem cell therapy treatment for cerebral palsy sri lanka by dr alok sharma, mumbai, india improvement seen in just 3 months after stem cell therapy treatment for cerebral palsy by dr alok sharma, mumbai, india. Stem Cell Therapy done date 4/10/201... By: Neurogen Brain and Spine Institute … Continue reading →

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Study examines stem cell role in breast cancer care

Posted: Published on January 23rd, 2014

Researchers at the Universitys Comprehensive Cancer Center, in collaboration with an international cohort, have developed means of identifying two states of breast cancer stem cells, giving them new clues as to how to treat patients with cancer. By distinguishing the different states, they hope to find more targeted and effective treatments for the disease, which kills over 40,000 people each year in the U.S., according to the American Cancer Society. What we found is that the stem cells actually are like chameleons that is they can exist in two different states, said Max S. Wicha, M.D., professor of Oncology and director of the University of Michigan Comprehensive Cancer Center. In breast cancer, a small fraction of cells act as seeds of the tumor, Wicha said. Cells in this state, known as epithelial-mesenchymal transition, are dormant but can spread to other organs in the body. The process of these cells spreading is called metastasis, and studying this process has been a key component of the research findings. The previous dearth of research on the dormant cells within the process of metastasis has posed a challenge to researchers trying to find new treatment options. As a matter of fact, in breast cancer, … Continue reading →

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SLU Researchers Study Therapy to Relieve Sickle Cell Pain

Posted: Published on January 23rd, 2014

Contact Information Available for logged-in reporters only Newswise ST. LOUIS -- Saint Louis University researchers are studying whether ReoPro (abciximab), a drug currently given to heart patients undergoing angioplasties to open blocked arteries, also could help children and young adults who have severe pain from sickle cell disease. Sickle cell crises, which are acute episodes that can land patients in the hospital, can be excruciatingly painful, said William Ferguson, M.D., director of the division of pediatric hematology and oncology at Saint Louis University and a SLUCare pediatrician at SSM Cardinal Glennon Childrens Medical Center. The typical vaso-occlusive crisis puts patients in the hospital for three to five days on intravenous medications. All we can do is give supportive care, such as pain killers, and wait for the crisis to run its course. Our research will tell us if using a medicine like ReoPro could be a valuable strategy in treating a sickle cell crisis. Sickle cell crises occur when clots form in the small blood vessels, preventing blood from flowing freely to organs. Healthy red blood cells are shaped like flexible donuts and can fold to easily wiggle through the smallest blood vessels. Red blood cells in patients who have … Continue reading →

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Scientists Find That Estrogen Promotes Blood-Forming Stem Cell Function

Posted: Published on January 23rd, 2014

Contact Information Available for logged-in reporters only Newswise DALLAS Jan. 22, 2014 Scientists have known for years that stem cells in male and female sexual organs are regulated differently by their respective hormones. In a surprising discovery, researchers at the Childrens Medical Center Research Institute at UTSouthwestern (CRI) and Baylor College of Medicine have found that stem cells in the blood-forming system which is similar in both sexes also are regulated differently by hormones, with estrogen proving to be an especially prolific promoter of stem cell self-renewal. The research, published in Nature, raises several intriguing possibilities for further investigation that might lead to improved treatments for blood cancers and increased safety and effectiveness of chemotherapy. Before the finding, blood-forming stem cells were thought to be regulated similarly in both males and females, according to the papers senior author, Dr. Sean Morrison, Director of CRI, Professor of Pediatrics, and the Mary McDermott Cook Chair in Pediatric Genetics at UTSouthwestern Medical Center. However, while working in Dr. Morrisons laboratory as postdoctoral fellows, Dr. Daisuke Nakada, the first and co-corresponding author of the study, and Dr. Hideyuki Oguro discovered that blood-forming stem cells divide more frequently in females than in males due to … Continue reading →

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14- The development of the vascular system – Video

Posted: Published on January 23rd, 2014

14- The development of the vascular system Animation is derived from Keith L. Moore, T.V.N. Persaud, Mark G. Torchia, "Before We Are Born: Essentials of Embryology and Birth Defects", 8th edition. Els... By: Embryology … Continue reading →

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