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Autism and Alternative Medicine

Posted: Published on January 13th, 2014

Getty Images With no approved medications to treat autism, more parents are turning to alternative therapies to help their kids. A new study published in theJournal of Developmental & Behavioral Pediatricsfound that among parents of nearly 600 children between ages 2 and 5 with autism (453 kids) and developmental delays (125 kids), 40% reported using homeopathic remedies, mind-body medicine, melatonin and probiotics in an attempt to relieve some of their childrens symptoms and even prevent some of the conditions behavioral problems from progressing. Such use ofcomplementary and alternative medicine (CAM)was 10% greater than that among nonautistic kids. About 7% of autistic kids were on a special diet such as gluten-free or casein-free, which parents believed could reduce inflammation that may aggravate autism symptoms. While most of the therapies were relatively harmless, a small number ofautistickids, 4%, were using treatments that the study classified as potentially unsafe or unfounded in science, like vitamin B-12 injections. The researchers therefore urge pediatricians to talk to parents about any complementary treatments they may be using on their kids, and educate well-intentioned parents about the potential risks and benefits of the therapies, including how the compounds mayinteractwith othertreatments. Last year, a study inPediatricsfound that CAM … Continue reading

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New MRI machines delivered to Seton

Posted: Published on January 13th, 2014

AUSTIN (KXAN) - Two new MRI systems delivered to Seton Medical Center Sunday won't only help Central Texans, but they will also help researchers advance stroke treatment across the U.S. One of the machines weighs more than seven tons and is valued at $2.5-million. The other is worth $2-million and weighs almost five tons. Seton says both machines provide the most advanced MRI technology available. The scanners use magnetic fields and radio waves to form images of the body. The new MRI machines will be used by researchers with the Seton/UT Southwestern Clinical Research Institute to improve stroke treatment. "We're going to be conducting research that will really advance the standard of accurate diagnosis and neurologic disorders and advance the theraputics... better treatements for these types of very serious illnesses," said Dr. Steven Warach with the Seton/UT Southwestern Clinical Research Institute. The MRI machines were unloaded off semi trucks using cranes and fork lifts. They were then moved through the hallways of Seton Medical Center, where they will be installed. Read the original here: New MRI machines delivered to Seton … Continue reading

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ALNY Opens Wallet, MNKD Gets FDA Panel Date, STEM Keeps Growing

Posted: Published on January 13th, 2014

Seeking to complement and extend its own progress and continued focus on RNAi therapeutics, Alnylam Pharmaceuticals Inc. (ALNY: Quote) has acquired Merck & Co. Inc.'s (MRK) subsidiary Sirna Therapeutics Inc. for an upfront payment of $175 million in cash and equity. The deal also entitles Merck to receive up to $105 million in developmental and sales milestone payments per product, as well as single-digit royalties, associated with the progress of certain pre-clinical candidates discovered by Merck and up to $10 million in milestone payments and single-digit royalties on Alnylam products covered by Sirna Therapeutics' patent estate. ALNY closed Friday's trading at $66.27, up 2.13%. Cubist Pharmaceuticals, Inc. (CBST: Quote) has submitted a Clinical Trial Application to the Dutch Competent Authority and Ethics Committee to initiate a first-in-human study of CB-618, a broad-spectrum beta-lactamase inhibitor to combat antibiotic resistence, in the Netherlands. If approved by the Dutch Competent Authority and Ethics Committee, Cubist plans to conduct the proposed initial study during the first half of 2014. CBST closed Friday's trading at $70.01, up 0.04%. MannKind Corp.'s (MNKD: Quote) resubmitted New Drug Application for AFREZZA with an indication to improve glycemic control in adults with type 1 or type 2 diabetes is … Continue reading

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Hypoxic- Anoxic Brain Injury |Ischemic Treatment, Prognosis …

Posted: Published on January 13th, 2014

A hypoxic-ischemic injury is the result of a lack of oxygen, which causes damage to brain cells and the spinal cord. This type of brain injury is most common before, during, or after childbirth, with statistics citing that two to four of 1,000 births result in hypoxic-ischemic injury. But while this type of brain injury is relatively rare, it can cause permanent brain damage and even death. While the exact causes of hypoxic-ischemic injury are unknown, some studies have linked placenta issues, maternal blood pressure problems, maternal uterine rupture, and umbilical cord complications to the injury. Symptoms include seizures and other signs of brain damage following childbirth. While hypoxic-ischemic injury has been studied frequently, a definitive way to prevent it or detect it before it does permanent damage to the newborn is still unknown. Because hypoxic-ischemic injury shares symptoms with other childbirth-related issues, it can be very difficult to diagnose in a timely manner. Approximately 15 to 20 percent of newborns with hypoxic-ischemic injury will die shortly after birth. Of those that survive the injury, about 25 percent will face lifelong neurological problems such as cerebral palsy, mental retardation, epilepsy, and learning disabilities. Go here to read the rest: Hypoxic- … Continue reading

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From medical mystery to costly overseas treatment for Mortlake woman

Posted: Published on January 13th, 2014

Jan. 13, 2014, 4 a.m. SHAKY handwriting on a birthday card seemed innocuous enough to Sheridan Jones, but it was the first sign of a rare disease that has robbed her of a previously active life. SHAKY handwriting on a birthday card seemed innocuous enough to Sheridan Jones, but it was the first sign of a rare disease that has robbed her of a previously active life. The Mortlake woman didnt dwell too long on her writing, putting it down to fatigue. It wasnt until a Tasmanian holiday two months later in March 2012 that she knew something was seriously wrong. Her right leg felt unusually heavy, like it was dragging against the will of the rest of her body. Sheridan went to see a neurologist, one of many, and a series of diagnoses failed to fully explain what was wrong with the once-healthy young woman. The explanation turned out to be more perplexing than the symptoms. Sheridan had contracted Lyme disease, a virus not officially recognised in Australia, yet she didnt even hold a passport at the time of contracting the rare infection. I remember calling up mum and saying my handwritings messy, my handwritings messy, the 26-year-old said. … Continue reading

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Breast cancer in Australia: Screening mammography and over-diagnosis

Posted: Published on January 13th, 2014

Joel Werner: So Heidi, where are we about to go into? Heidi Hilton: We're going into the tissue culture lab. So this is where we spend a lot of our time, we do cell culture experiments growing breast cancer cell lines as well as normal breast tissue. So you can see that we have a bunch of incubators where we store all our cells at 37 degrees, and these are the tissue culture hoods. Any time that we handle the cells it has to be completely sterile, so these tissue culture hoods are where we carry out our sterile work. Joel Werner: This is Dr Heidi Hilton. She is a breast cancer researcher. You're listening to the Health Report on RN, I'm Joel Werner, filling in for Norman Swan. And over the next few weeks we're examining breast cancer in Australia in 2013. Heidi Hilton: So we are in the lab of the breast group at the Westmead Millennium Institute, and our group is interested in understanding how the female hormone progesterone works. So we know that progesterone is critical in normal breast development but we also know that it's a major driver of breast cancer risk, and this is … Continue reading

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Stem cell research identifies new gene targets in patients …

Posted: Published on January 13th, 2014

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (ISMMS) successfully generated a stem cell model of familial Alzheimer's disease (FAD). Using this stem cell model, researchers identified fourteen genes that may be implicated in the disease and one gene in particular that shows the importance that inflammation may play in the brain of Alzheimer's patients. In this study, published today in PLOS ONE, the team of scientists produced stem cells and neural precursor cells (NPCs), representing early neural progenitor cells that build the brain, from patients with severe early-onset AD with mutations in the Presenilin 1 (PSEN1) gene. These NPCs had elevated Abeta42/Abeta40 ratios, indicating elevation of the form of amyloid found in the brains of Alzheimer's patients. These levels were greater than those in adult cells that did not have the PSEN1mutation. This elevated ratio showed that these NPCs grown in the petri dish were accurately reflecting the cells in the brains of FAD patients. "Our ability to accurately recapitulate the disease in the petri dish is an important advance for this disease. These genes provide us with new targets to help elucidate … Continue reading

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Cambridge learns how to rewire stem cells

Posted: Published on January 13th, 2014

New technology developed by Cambridge UK researchers could rewire stem cells and help fight conditions such as heart & liver disease as well as cancer. The fast-working technique determines what causes stem cells to convert into other cell types and could revolutionise understanding of how genes function. The method uses stem cells with a single set of chromosomes, instead of the two sets found in most cells, to reveal what causes the circuitry of stem cells to be rewired as they begin the process of conversion into other cell types. The same method could also be used to understand a range of biological processes. Embryonic stem cells rely on a particular gene circuitry to retain their original, undifferentiated state, making them self-renewing. The dismantling of this circuitry is what allows stem cells to start converting into other types of cells - a process known as cell differentiation - but how this happens is poorly understood. The method uses stem cells with a single set of chromosomes to uncover how cell differentiation works. Cells in mammals contain two sets of chromosomes one set inherited from the mother and one from the father. This can present a challenge when studying the function … Continue reading

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Multiple myeloma study uncovers genetic diversity within tumors

Posted: Published on January 13th, 2014

PUBLIC RELEASE DATE: 13-Jan-2014 Contact: Haley Bridger hbridger@broadinstitute.org 617-714-7968 Broad Institute of MIT and Harvard The most comprehensive genetic study to date of the blood cancer multiple myeloma has revealed that the genetic landscape of the disease may be more complicated than previously thought. Through results published in Cancer Cell today, a team of Broad researchers has shown that an individual patient's tumor can harbor populations of cancer cells equipped with different mutations. These findings could have therapeutic implications for patients in the future. "What this new work shows us is that when we treat an individual patient with multiple myeloma, it's possible that we're not just looking at one disease, but at many in the same person, there could be cancer cells with different genetic make-ups," said co-senior author Todd Golub, the Broad Institute's Chief Scientific Officer and Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute. Golub is also a professor at Harvard Medical School and an investigator at Howard Hughes Medical Institute. "These findings indicate a need to identify the extent of genetic diversity within a tumor as we move toward precision cancer medicine and genome-based diagnostics." In a detailed study of samples … Continue reading

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Author and Entrepreneur Steven Zecola Highlights the Fallacies of the FDA’s Approach to Personal Genetic Information

Posted: Published on January 13th, 2014

Washington, D.C. (PRWEB) January 13, 2014 The Food and Drug Administrations new approach to personalized medicine was sent in motion on November 22, 2013 with its warning letter to 23andme regarding the provision of personal genetic information to customers. The FDA found that 23andmes offering to be a device that was intended for use in the diagnosis of disease or other conditions or in the cure, mitigation, treatment, or prevention of disease and that in certain circumstances it could lead a patient to undergo prophylactic surgery, chemoprevention, intensive screening, or other morbidity-inducing action. Accordingly, the FDA found 23andme in violation of the Federal Food, Drug and Cosmetic Act by marketing its product without acquiring prior approval from the FDA. Zecola explains that such an approach is misguided for several reasons: 1) The provision of personal genetic information is just that, an information service. The FTC, not the FDA, has jurisdiction over information services in determining whether they are fraudulent. 2) The action is paternalistic and impinges upon personal liberty. The personal genetics companies include disclaimers on their websites and materials saying that their customers should not take action on the personal genetic information but rather should consult with a certified … Continue reading

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