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An expert consensus on acute thoracolumbar spine and spinal cord injury in China

Posted: Published on December 23rd, 2013

PUBLIC RELEASE DATE: 23-Dec-2013 Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research The early management of acute thoracolumbar spine and spinal cord injury is one of the most difficult tasks when treating trauma cases. To standardize the evaluation and treatment of acute thoracolumbar spinal injury, the Chinese Association of Spine and Spinal Cord Injury organized a group of Chinese experts to collectively discuss the draft of "An Expert Consensus on the Evaluation and Treatment of Acute Thoracolumbar Spine and Spinal Cord Injury". The report is based on a detailed literature search and analysis of evidence-based medicine and clinical experiences as well as Delphi method. This is the first time that Chinese experts have published a consensus on spine and spinal cord injury. Experts from the Beijing Army General Hospital of Chinese PLA drafted this consensus. This consensus is a standard for the management of acute spine and spinal cord injury and was approved by domestic experts. It could standardize the evaluation and treatment of acute thoracolumbar spine and spinal cord injury. The relevant contents were published in the Neural Regeneration Research (Vol. 8, No. 33, 2013). ### Article: " An expert consensus on the evaluation and treatment of acute thoracolumbar … Continue reading →

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Jerusalem Shriners host Christmas party for patients in Destrehan

Posted: Published on December 23rd, 2013

The Jerusalem Shriners held their annual Christmas party for patients of Shriners Hospitals for Children on Dec. 14 at the Shrine Center in Destrehan. About 60 patients who have received free medical care at Shriners Hospitals for Children and their families attended the party. Santa arrived with a Shriners green and yellow Harleys motorcycle escort. A winter wonderland was created for Shriners and patient to walk through. Gifts from Santas, food, and music were among the highlights. Shriners Hospitals for Children offer free care and treatment for children suffering from orthopaedics, burns, cleft lip and palate, and spinal cord injury. The Destrehan High baseball team will hold its annual vegetable sale fund-raiser Dec. 29-31 in Norco and Destrehan. Players will be selling cabbage, cauliflower, brocolli, mustard greens, turnips and romanesco. Other vegetables may be available. All vegetables are grown at Timmy Perrilouxs garden in Montz. The team will be set up at north and south bound on Airline Highway near Apple Street in Norco, Ormond Boulevard near the Shriners Hall, River Road and Ormond Boulevard on the levee in Destrehan, and River Road near by Charleston subdivision. Dance The Oldies but Goodies dance and social club will hold a New … Continue reading →

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Inosine treatment safely elevates urate levels in Parkinson’s disease patients

Posted: Published on December 23rd, 2013

PUBLIC RELEASE DATE: 23-Dec-2013 Contact: Mike Morrison mdmorrison@partners.org 617-724-6425 Massachusetts General Hospital A clinical trial assessing the potential of the nutritional supplement inosine to treat Parkinson disease has found that the studied dosages successfully raised participants' levels of the antioxidant urate without producing serious side effects. Results of the two-year phase 2 trial conducted by a consortium led by investigators at Massachusetts General Hospital (MGH), Harvard School of Public Health, and the University of Rochester are being published in JAMA Neurology. Several previous studies have suggested that urate elevation may reduce the risk of Parkinson disease or slow its progression. "This study provided clear evidence that, in people with early Parkinson disease, inosine treatment can safely elevate urate levels in the blood and cerebrospinal fluid for months or years," says Michael Schwarzschild, MD, PhD, principal investigator of the study and an MGH neurologist. "We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease-modifying strategy in Parkinson's; so the positive results of this trial are very encouraging." Characterized by tremors, rigidity, difficulty walking and other symptoms, Parkinson disease is caused by the destruction of brain cells that … Continue reading →

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Study examines inosine to increase urate levels in patients with Parkinson disease

Posted: Published on December 23rd, 2013

PUBLIC RELEASE DATE: 23-Dec-2013 Contact: Mike Morrison mdmorrison@partners.org 617-724-6425 The JAMA Network Journals The drug inosine appears to be a safe and effective way to raise blood and cerebrospinal fluid urate levels in patients with early Parkinson disease (PD), suggesting it may be a potential strategy to slow the disability progression of the degenerative neurological disorder, according to a report published by JAMA Neurology, a JAMA Network publication. Urate is an end product of human metabolism. Animal experiments suggest that urate may protect against PD, and higher blood urate levels are associated with reduced risk and slower progression of PD, according to the study background. Inosine is a drug that raises urate levels and therefore may be useful for PD. Researchers in the Parkinson Disease Study Group SURE-PD (Safety of Urate Elevation in PD) trial randomized 75 patients with early PD (average age 62 years and not yet requiring treatment for their symptoms) to placebo or doses of inosine to produce mild or moderate elevation in blood urate levels to examine the safety, tolerability and ability of inosine to elevate urate levels. Patients were administered inosine in 500-mg capsules taken orally. Blood (serum) urate levels rose by 2.3 and 3.0 … Continue reading →

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Traumatic Brain Injury Rehabilitation and Treatment

Posted: Published on December 23rd, 2013

Acquired brain injury can result from internal or external causes including external physical forces, hypoxia (lack of sufficient oxygen), stroke, disease, or tumor. It is not due to congenital (i.e., genetic or birth defects) or degenerative causes (e.g., Alzheimers Disease). Specific examples are: 1) Traumatic brain injury (TBI) or concussion from a blow to the head; (tramatic brain injury [sp.]) 2) Hypoxia due to near-drowning, prolonged seizures, or drug overdose; 3) Stroke due to hemorrhage (e.g., bleeding from a ruptured aneurysm or trauma) or ischemia (insufficient blood supply from a blockage of a blood vessel); 4) Disease due to inflammation (e.g., infections), toxicity, metabolic abnormalities (e.g., liver or kidney dysfunction), seizures, demyelinating disorders (e.g., multiple sclerosis), or increased intracranial pressure; 5) Tumors (malignant or nonmalignant). Regardless of the cause, parts of the brain are no longer able to function normally. This can result in cognitive, emotional, behavioral, or physical impairments. These may be either temporary or permanent and may cause partial or total functional disability or psychosocial difficulties. The Brain Therapy Center provides free information, neuropsychological assessment, treatment, current research information, and helpful tips. Currently, 5.3 million Americans are living with a disability caused by brain injury. Fortunately there are … Continue reading →

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2013: The Best Biomedicine Stories of the Year

Posted: Published on December 23rd, 2013

By Susan Young While the fights and fumbles over the Affordable Care Act dominated headlines in 2013, the year was also heady with advances in biomedicine. In April, President Obama announced an ambitious federal initiative to map the activity of all the neurons in a brain circuit or, ideally, a whole brain. The $100 million Brain Research through Advancing Innovative Neurotechnologies (BRAIN) project will support neuroscientists, nanotechnologists, and others who propose to develop new technologies that can monitor thousands of neurons simultaneously. The hope is that such new innovations could help neuroscientists understand the biological origin of cognition and perception and speed the development of treatments for disorders such as autism or post-traumatic stress disorder. There was remarkable progress in the field of neuroscience this year, but researchers still struggle to understand and treat the brain. This year, the FDA approved the first artificial retina prosthetic for use in the United States following the California-made devices European approval in 2011. That light-detecting system can replace some of the visual information lost by patients whose retinas, which are an extension of brain tissue, have become damaged by genetic disease. A German company announced that an alternative retina prostheses system had helped … Continue reading →

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Opexa Therapeutics, Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters …

Posted: Published on December 23rd, 2013

Opexa intends to use the net proceeds from the offering to continue funding the ongoing Abili-T clinical study of Tcelna in patients with Secondary Progressive MS and for general corporate purposes (including working capital, research and development, business development and operational purposes). Aegis Capital Corp. acted as sole book-running manager for the offering. The offering was made pursuant to a shelf registration statement on Form S-3 that was filed by Opexa with the Securities and Exchange Commission (SEC) and declared effective by the SEC on December5, 2012. Copies of the prospectus supplement relating to and describing the terms of the offering are available on the SECs web site at http://www.sec.gov. Copies of the prospectus supplement relating to these securities may also be obtained from the offices of Aegis Capital Corp., Prospectus Department, 810 Seventh Avenue, 18thFloor, New York, NY, 10019, via telephone at (212) 813-1010, or via email at prospectus@aegiscap.com. This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale is not permitted. About Opexa Opexas mission is … Continue reading →

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We don’t need the Americans to tell us what to do!

Posted: Published on December 23rd, 2013

'When all the facts are known, if they ever are, it will likely turn out that both Ms Khobragade and Ms Richard might have been at fault and so too might both governments be faulted, the US for a needlessly aggressive approach in the first place and India for its ham-handed response in the early stages of the affair,' says Rupa Subramanya. Strangely, various commentary has been quick to condemn Ms Khobragade, and unquestioningly accepted Ms Richard's version of events, painting her as a helpless victim. India is once again, it would appear, on the wrong side of international (mostly Western) public opinion. The arrest of Devyani Khobragade, the deputy consul general for India in New York over alleged visa fraud by paying her domestic help, a Government of India employee, less than the legal minimum wage in the state of New York, has caused a diplomatic row between the US and India. The case has garnered international notice for the harsh spotlight that it apparently casts on working conditions in India (in particular, how middle class and well-to-do Indians treat their domestic help) and of Indians working abroad in diplomatic missions. Equally, the case has received much attention in … Continue reading →

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Happy, healthy holidays for Mary Buie on her path to recovery

Posted: Published on December 23rd, 2013

EDITORS NOTEThis is the fifteenth story in an ongoing series that is following Kagawongs Mary Buie and her brave battle with breast cancer. The series is chronicling Ms. Buies journey as she navigates through doctors appointments, surgery, chemotherapy and recovery as well as exploring the various groups and resources that exist on Manitoulin for women fighting the disease. No stranger to uphill battles, Ms. Buie, an English-trained nurse, pushed emphatically for Ontario to recognize midwifery as a medical discipline and then returned to university to re-qualify as a midwife before founding Manitoulin Midwifery. KAGAWONGMary Buie is looking forward to the holidays this year. With her health and energy up she assured The Expositor she would be making the most of the season. I feel great, said Ms. Buie. I am doing well and so thankful that my health has improved and I have my energy back for the holidays. This time last year Ms. Buie was recovering from a modified radical mastectomy and undergoing chemotherapy treatment. Though she maintained her positive outlook, her energy was down and she was preparing for further treatment in the New Year. 2013 brought great news for Ms. Buie as she learned she was officially … Continue reading →

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Treatment – MED – Ataxia Center, University of Minnesota

Posted: Published on December 23rd, 2013

There are no specific, effective drug treatments for the lack of coordination seen with ataxia. Amantadine, buspirone hydrochloride (BuSpar) and modafinil (Provigil) are often tried with variable success. For episodic ataxia, acetazolamide (Diamox) or topiramate (Topamax) can be effective. Clonazepam (Klonopin) is effective in treating specific symptoms, such as muscle jerking (myoclonus) and sleep disturbances. Depression is common in patients with cerebellar ataxia. This is understandable in terms of the disability resulting from the condition. Recent research also indicates that patients with cerebellar ataxia may be prone to depression because of dysfunction of the cerebellum. Medication and emotional support are usually effective in treatment of depression in cerebellar ataxia. Physical therapy, including stretching, conditioning and strengthening exercise, is also important. People who are not overweight, well conditioned, and flexible cope better with ataxia symptoms. Physical therapy and occupational therapy can also help evaluate the need for mobility and safety aids and help choose the appropriate aid for a particular patient. Home safety evaluations and recommendations for modifications are also performed more effectively by occupational therapists. Speech therapy can help with evaluating swallowing and teaching the patient about how to speak clearly and avoid choking. Continued here: Treatment - MED - … Continue reading →

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