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UCLA Scientists First to Track Joint Cartilage Development in Humans

Posted: Published on December 12th, 2013

Contact Information Available for logged-in reporters only Newswise Stem cell researchers from UCLAs Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have published the first study to identify the origin cells and track the early development of human articular cartilage, providing what could be a new cell source and biological roadmap for therapies to repair cartilage defects and osteoarthritis. These revolutionary therapies could reach clinical trials within three years. Led by Dr. Denis Evseenko, assistant professor of orthopedic surgery and head of UCLAs Laboratory of Connective Tissue Regeneration, the study was published online ahead of print in Stem Cell Reports on December 12, 2013. Articular cartilage is a highly specialized tissue formed from cells called chondrocytes that protect the bones of joints from forces associated with load bearing and impact, and allows nearly frictionless motion between the articular surfaces. Cartilage injury and lack of cartilage regeneration often lead to osteoarthritis involving degradation of joints, including cartilage and bone. Osteoarthritis currently affects more than 20 million people in the United States alone, making joint surface restoration a major priority in modern medicine. Different cell types have been studied with respect to their ability to generate articular cartilage. … Continue reading

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California’s Stem-Cell Quest Races Time as Money Dwindles

Posted: Published on December 12th, 2013

Californias government-run stem-cell research agency, on course to spend $3 billion in taxpayer money to find treatments for some of the worlds most intractable diseases, is pushing to accelerate human testing before its financing runs out. For the California Institute for Regenerative Medicine, time is growing short to fund research that demonstrates the potential of stem cells to help treat everything from cancer to heart disease to spinal cord injuries. The agency, created by voters in 2004, has given out more than half of its $3 billion from state bonds and must spend the rest by 2017. The largest U.S. funding source for stem-cell research outside the federal government, its under pressure to show results to attract new money from pharmaceutical companies, venture capitalists or even more municipal bonds. We need to figure out how to keep them going, said Jonathan Thomas, a founding partner of Saybrook Capital LLC in Los Angeles, and chairman of the institutes board, which meets today. We could do public-private partnerships, venture philanthropy, a ballot box. Embryonic stem cells have the potential to change into any type of cell in the body. They are among the first cells created in embryos after conception. Scientists hope … Continue reading

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Why Dementia Drugs Work in Lab but Not in Humans

Posted: Published on December 12th, 2013

By Rick Nauert PhD Senior News Editor Reviewed by John M. Grohol, Psy.D. on December 9, 2013 Researchers have been on a fast-track to develop drugs to slow or prevent Alzheimers disease. And whilemany of the new compounds appear to work well in animal and cell models, they have all failed in human clinical trials. In a new study, reported online in the journal Stem Cell Reports, researchers provide interesting clues on the failures. In the article, experts suggest why non-steroidal anti-inflammatory drugs (NSAIDs) which have successfully treated molecular signs of Alzheimers disease in cell and animal models eventually failed in clinical studies. They discovered that although the compounds worked in non-neuronal cells lines typically used in pharmaceutical drug screening, human neurons are resistant to this class of drugs. The results of our study are significant for future drug development approaches, because they imply that compound screening and validation studies might be much more reliable if they are conducted using the human cell type affected by the disease in question, said Oliver Brstle who senior-authored the study with colleague Philipp Koch, M.D. Alzheimers disease is the most common cause of dementia among older people, yet there currently are no effective … Continue reading

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Human stem cells predict efficacy of Alzheimer drugs

Posted: Published on December 12th, 2013

Dec. 6, 2013 Why do certain Alzheimer medications work in animal models but not in clinical trials in humans? A research team from the University of Bonn and the biomedical enterprise LIFE & BRAIN GmbH has been able to show that results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain. Drug testing should therefore be conducted with human nerve cells, conclude the scientists. The results are published by Cell Press in the journal Stem Cell Reports. In the brains of Alzheimer patients, deposits form that consist essentially of beta-amyloid and are harmful to nerve cells. Scientists are therefore searching for pharmaceutical compounds that prevent the formation of these dangerous aggregates. In animal models, certain non-steroidal anti-inflammatory drugs (NSAIDs) were found to a reduced formation of harmful beta-amyloid variants. Yet, in subsequent clinical studies, these NSAIDs failed to elicit any beneficial effects. "The reasons for these negative results have remained unclear for a long time," says Prof. Dr. Oliver Brstle, Director of the Institute for Reconstructive Neurobiology of the University of Bonn and CEO of LIFE & BRAIN GmbH. "Remarkably, these compounds were never … Continue reading

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The Advantages Of Autologous Stem Cell Transplants and Cryotherapy – Video

Posted: Published on December 12th, 2013

The Advantages Of Autologous Stem Cell Transplants and Cryotherapy http://www.mslaw.edu In this excerpt from the Massachusetts School of Law's Educational Forum featuring Assistant Dean Diane Sullivan's journey through a ste... By: MSLawdotedu … Continue reading

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Pakistani undergoes stem cell therapy in Bangalore

Posted: Published on December 12th, 2013

Bangalore, Dec 12 (IANS) Imran Qureshi, a 31-year-old Pakistani, underwent stem cell therapy for hip joint at a private hospital here. "Qureshi, a garment exporter from Karachi port city, has been treated for hip bone joint through stem cell therapy by our experts at the Bangalore Institute of Regenerative Medicine," Live 100 Hospital chairman H.N. Nagaraj told reporters Thursday. The disease, known as avascular necrosis in medical jargon, breaks the hip joint due to the cellular death of its bone tissues when blood supply is interrupted even in healthy people. "Though total hip replacement is suggested as one of the treatments for the rare disease, our institute has pioneered stem cell therapy, eliminating surgery," Nagaraj said, presenting Qureshi as one of his hospital's overseas beneficiaries. The treatment involves first extracting bone marrow of the patient for processing in a specialised laboratory at Pune, Maharashtra. Subsequently, the stem cells in the bone marrow are separated from red blood cells and blood plasma and injected into the hip joint of a patient under sterile conditions. "The transplanted stem cells restore hip joint function, which is lost due to damage to its cartilage. The stems cells also repair bone cells. As there is … Continue reading

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Stem cell transplantation outcomes 'improved with new drug regime'

Posted: Published on December 12th, 2013

Current ratings for: Stem cell transplantation outcomes 'improved with new drug regime' Ratings require JavaScript to be enabled. New research suggests that outcomes for patients who have undergone stem cell transplants from unrelated or mismatched donors could be improved with the use of a drug called bortezomib, also known as velcade. This is according to a study presented at the annual meeting of the American Society of Hematology. Stem cell transplants are treatments carried out in an attempt to cure some cancers affecting the body's bone marrow, such as leukemia, lymphoma and myeloma. The treatment involves very high doses of chemotherapy (myeloablation) or whole body radiotherapy to clear a person's bone marrow and immune system of cancerous cells. After this process, the killed cells are replaced with healthy stem cells through a drip that flows into a vein. These stem cells can be from the patient's own body or from a donor - preferably a sibling. According to researchers from the Dana-Farber Cancer Institute who conducted the study, stem cells from unrelated or mismatched donors are likely to lead to worse patient outcomes following transplantation. These patients tend to have a higher mortality rate as a result of the treatment … Continue reading

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Phoenix Pain Management Doctors at Arizona Pain Stem Cell Institute Now Offering 4 Stem Cell Treatments for Arthritis

Posted: Published on December 12th, 2013

Phoenix, Arizona (PRWEB) December 11, 2013 The top Phoenix stem cell treatment clinic, Arizona Pain Stem Cell Institute, is now offering four stem cell therapies for arthritis. The treatments offered are very low risk and offered as an outpatient. For more information and scheduling on the regenerative medicine treatments offered, call (602) 507-6550. The Board Certified, Award Winning pain management doctors in Arizona provide either bone marrow, fat derived or amniotic stem cell injections. The fat or bone marrow is harvested from the patient, and immediately processed for injection into the target area. Since the material comes directly from the patient, the risks are exceptionally low. With regards to the amniotic derived injections, the fluid is obtained from consenting donors and processed at an FDA regulated lab. The treatment does not involve any fetal tissue, and contains a high concentration of stem cells, growth factors and anti-inflammatory factors. The additional treatment offered is platelet rich plasma therapy, known as PRP therapy for short. PRP therapy involves a simple blood draw from the patient, which is then centrifuged and spun down for 15 minutes to obtain a solution rich in platelets and growth factors. The PRP is then injected into the … Continue reading

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UTHealth Researchers Study Stem Cell Treatments for Children with CP

Posted: Published on December 12th, 2013

Contact Information Available for logged-in reporters only Newswise HOUSTON (Dec. 10, 2013) A first-of-its-kind clinical trial studying two forms of stem cell treatments for children with cerebral palsy (CP) has begun at The University of Texas Health Science Center at Houston (UTHealth) Medical School. The double-blinded, placebo-controlled studys purpose includes comparing the safety and effectiveness of banked cord blood to bone marrow stem cells. It is led by Charles S. Cox, Jr., M.D., the Childrens Fund, Inc. Distinguished Professor of Pediatric Surgery at the UTHealth Medical School and director of the Pediatric Trauma Program at Childrens Memorial Hermann Hospital. Co-principal investigator is Sean I. Savitz, M.D., professor and the Frank M. Yatsu, M.D., Chair in Neurology in the UTHealth Department of Neurology. The study builds on Cox extensive research studying stem cell therapy for children and adults who have been admitted to Childrens Memorial Hermann and Memorial Hermann-Texas Medical Center after suffering a traumatic brain injury (TBI). Prior research, published in the March 2010 issue of Neurosurgery, showed that stem cells derived from a patients own bone marrow were safely used in pediatric patients with TBI. Cox is also studying cord blood stem cell treatment for TBI in a separate … Continue reading

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A step closer to muscle regeneration

Posted: Published on December 12th, 2013

PUBLIC RELEASE DATE: 9-Dec-2013 Contact: Courtney Karayannis courtney.karayannis@monash.edu 61-408-508-454 Monash University Muscle cell therapy to treat some degenerative diseases, including Muscular Dystrophy, could be a more realistic clinical possibility, now that scientists have found a way to isolate muscle cells from embryonic tissue. PhD Student Bianca Borchin and Associate Professor Tiziano Barberi from the Australian Regenerative Medicine Institute (ARMI) at Monash University have developed a method to generate skeletal muscle cells, paving the way for future applications in regenerative medicine. Scientists, for the first time, have found a way to isolate muscle precursor cells from pluripotent stem cells using a purification technique that allows them to differentiate further into muscle cells, providing a platform to test new drugs on human tissue in the lab. Pluripotent stem cells have the ability to become any cell in the human body including, skin, blood, brain matter and skeletal muscles that control movement. Once the stem cells have begun to differentiate, the challenge for researchers is to control the process and produce only the desired, specific cells. By successfully controlling this process, scientists could provide a variety of specialised cells for replacement in the treatment of a variety of degenerative diseases such as Muscular … Continue reading

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