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Mesenchymal Stem Cells in the treatment of Systemic Lupus …

Posted: Published on November 28th, 2013

by Neil Riordan, P.A., Ph.D. Neil Riordan, P.A., Ph.D. There are four different types of lupus erythematosus, a group of diseases commonly referred to simply as "lupus." Systemic lupus erythematosus(SLE) is the most common and serious form. Professor Lingyun Sun and his colleagues have written five key articles about the treatment of Systemic Lupus Erythematosus (Lupus) with mesenchymal stem cells. I had the pleasure of meeting Professor Sun on a trip to China in 2010. Dr. Sun is at Nanjing University Medical School, in Nanjing, China. The first of the series1, published in 2009, firstly described benefits of mesenchymal stem cells (MSCs) in a mouse Lupus model. From the positive outcomes they saw in that model, they then went to humans and treated a series of 4 people who were not responding to treatment with cyclophosphamide and steroids for more than six months. Both the mice and humans were treated with donor bone marrow mesenchymal cells that were grown in the laboratory. The lupus patients received a single intravenous (IV) infusion of 1 million cells per kilogram of body weight. For an average sized person the dose would have been 70 million cells. The patients were tapered off of their … Continue reading

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Mesenchymal Stem Cells | Stem Cell Treatment, Therapy | Stem …

Posted: Published on November 28th, 2013

Home > Stem Cell Therapy > Mesenchymal Stem Cells Call us for more information 561-320-1256 Image credit to Robert M. Hunt Mesenchymal stem cells, or MSCs for short, are multipotent stem cells that can differentiate themselves into a number of different cells including osteoblasts, chondrocytes and myocytes. More recent discoveries have indicated that MSCs can also differentiate into beta-pancreatic islets cells. MSCs can be shown in vitro and in vivo as well as ex vivo, which means that they can be cultivated and shown outside of a host organism. MSCs are found in bone marrow, although they are relatively rare and represent only around one in 10,000 nucleated cells. They are not immortal, but they are capable of expanding in cultures while maintaining their multilineage potential. These properties along with their versatility make them invaluable to stem cell treatment and stem cell therapy. Perhaps the most promising characteristic of MSCs is their potential to be used in tissue engineering. Preliminary experiments on lab animals have shown that the cells can migrate to injury sites when they are transplanted systematically, although the method of this migration remains unclear. The chemokine receptors and adhesion molecules of the stem cells allow them to … Continue reading

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Epilepsy — Diagnosis and Treatment at Mayo Clinic

Posted: Published on November 28th, 2013

Epilepsy is a central nervous system disorder (neurological disorder) in which the nerve cell activity in your brain is disturbed, causing a seizure during which you experience abnormal behavior, symptoms and sensations, including loss of consciousness. Seizure symptoms vary. Some people with epilepsy simply stare blankly for a few seconds during a seizure, while others repeatedly twitch their arms or legs. About 1 in 100 people in the United States may have an unprovoked seizure once in life. However, a solitary seizure doesn't mean you have epilepsy. At least two unprovoked seizures are generally required for an epilepsy diagnosis. Even mild seizures may require treatment because they can be dangerous during activities such as driving or swimming. Treatment, which generally includes medications or sometimes surgery, may eliminate or reduce the frequency and intensity of seizures. Some children with epilepsy even outgrow the condition with age. Expertise and experience. Mayo Clinic doctors trained in brain and nervous system conditions (neurologists) and brain and nervous system surgery (neurosurgeons) have expertise and experience in evaluating and treating people with epilepsy. Neurologists and neurosurgeons at Mayo Clinic in Minnesota have experience treating children with epilepsy. Researchers also study potential treatments including medications, deep brain … Continue reading

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Treatment – Epilepsy Advocate

Posted: Published on November 28th, 2013

The good news is there are excellent medications available now that can help patients strive for no seizures and limited side effects. Today, patients and their physicians are demanding excellence in epilepsy medications and treatment. It is okay to demand more from your epilepsy medication and to have the goal of achieving 100% seizure freedom. Your first step may be to see your primary care doctor and to get a referral to a neurologist or epileptologist who has the deepest knowledge in the field. Before your medical visit, write down any questions you have. If possible, write down everything you remember about what brings on your seizures, and also be prepared to discuss your medical history including any past injuries. Questions your neurologist may ask include: Epilepsy can be a complicated condition, and you need to learn as much as you can to achieve seizure freedom; so make sure you ask questions. Together with your neurologist or epileptologist, you can make the best decision for your health. Back to top There are over a dozen medications currently available for epilepsy treatment. Epilepsy medications are either called first-generation or second-generation, depending on when they were first discovered and made available. Some … Continue reading

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Autism: Treatments and drugs – MayoClinic.com

Posted: Published on November 28th, 2013

Our weekly general interest e-newsletter keeps you up to date on a wide variety of health topics. No cure exists for autism, and there is no one-size-fits-all treatment. The range of home-based and school-based treatments and interventions for autism can be overwhelming. The goal of treatment is to maximize your child's ability to function by reducing autism symptoms and supporting development and learning. Your doctor can help identify resources in your area. Treatment options may include: Managing other medical conditionsChildren with autism may also have other medical conditions, such as epilepsy, sleep disorders, limited food preferences or stomach problems. Ask your child's doctor how to best manage these conditions together. Keep all of your child's health care providers updated on any medications and supplements your child is taking. Some medications and supplements can interact, causing dangerous side effects. Teens and young adults with autism may have issues with body changes, increased social awareness and transitions. Your health care provider and community advocacy and service organizations can offer help. Read more: Autism: Treatments and drugs - MayoClinic.com … Continue reading

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Treatments for Autism – About.com Autism Spectrum Disorders

Posted: Published on November 28th, 2013

While there is no established cure for autism, there are many therapies that can help. Some help manage symptoms, other teach social and behavioral skills, and still others are intended to cure autism altogether. Find out what's out there, what seems to work for whom, and how to figure out whether a treatment is working well for you or your child. Before you plunge into selecting an autism treatment (or several treatments!), it's important to know what your options are, and how to evaluate whether a treatment is working. These articles will give you an introduction to both topics. There are many theories regarding the causes and "core deficits" of autism. As a result, there are many different types of therapies and treatments developed specifically to alleviate symptoms of autism spectrum disorders. On the upside, that means you have a range of options to try. On the downside, it means you never know whether you've tried the most effective option for you or your child. Because there are so many choices -- and no "one best choice" -- most families try at least a few types of treatment. And most find that some combination of treatments make a real difference. … Continue reading

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Spinal Cord Injury Treatment, Recovery, Rehabilitation

Posted: Published on November 28th, 2013

Treatment for spinal cord injuries can be divided into to two stages: acute and rehabilitation. The acute phase begins at the time of injury, and lasts until the person is stabilized. The rehabilitation phase begins as soon as the person has stabilized and is ready to begin working toward his or her independence. During the acute phase, it is very important that the person receive prompt medical care. The faster the person accesses treatment, the better his or her chances are at having the least amount of impairment possible. In most cases, the injured person will be sent to the closest hospital or center equipped to deal with spinal cord injuries. The first few days of the acute stage are accompanied by spinal shock, in which the persons reflexes dont work. During this stage, its very difficult to determine an exact prognosis, as some function beyond what is currently being seen may occur later. At this stage other complications from the accident or injury will also be present, such as brain injury, broken bones, or bruising. Once the acute phase is over and the person has been stabilized, he or she enters the rehabilitation stage of treatment. Treatment during this … Continue reading

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Oxygen Treatment May Help Some With Spinal Cord Injuries: Study

Posted: Published on November 28th, 2013

From Published: November 27, 2013 4:35 PM By Serena Gordon HealthDay Reporter Breathing treatments that provide low levels of oxygen may help people with certain types of spinal cord injuries walk longer distances at faster speeds, new Canadian research indicates. After the low-oxygen treatment, people with less severe spinal cord injuries were able to walk approximately 33 feet about four seconds faster than those on a placebo treatment. They also were able to increase the distance they could walk in six minutes by about 328 feet. "The rehabilitation world after a spinal cord injury can be frustrating and limited," said study author Randy Trumbower, an assistant professor in the division of physical therapy at the Emory University School of Medicine in Atlanta. "After the first year, it's a lifelong journey to overcome their diagnosis. Someone may be able to cross the street right now, but can they do it in enough time? Or someone might be able to get to the grocery store, but do they have the endurance to shop?" BLOG: The Daily Apple | PHOTOS: Dropping LBs DATA: Explore hospital rankings | Narcotics by community WEIGH IN: Ask your fitness questions "We wanted to find a treatment that … Continue reading

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Cerebral palsy: Treatments and drugs – MayoClinic.com

Posted: Published on November 28th, 2013

Our weekly general interest e-newsletter keeps you up to date on a wide variety of health topics. Children and adults with cerebral palsy require long-term care with a medical care team. This team may include: MedicationsMedications that can lessen the tightness of muscles may be used to improve functional abilities, treat pain and manage complications related to spasticity or other cerebral palsy symptoms. It's important to talk about the risk of drug treatments with your doctor and discuss whether medical treatment is appropriate for your child's needs. The selection of medications depends on whether the problem affects only certain muscles (isolated) or the whole body (generalized). Drug treatments may include the following: Isolated spasticity. When spasticity is isolated to one muscle group, your doctor may recommend injections of onabotulinumtoxinA (Botox) directly into the muscle, nerve or both. Botox injections may help to improve drooling. Your child will need injections about every three months. Side effects may include pain, bruising or severe weakness. Other more-serious side effects include difficulty breathing and swallowing. Generalized spasticity. If the whole body is affected, oral muscle relaxants may relax stiff, contracted muscles. These drugs include diazepam (Valium), dantrolene (Dantrium) and baclofen (Gablofen). There is some … Continue reading

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Ataxic cerebral palsy – Wikipedia, the free encyclopedia

Posted: Published on November 28th, 2013

Ataxic cerebral palsy is clinically observed in approximately 5-10% of all cases of cerebral palsy, making it the least frequent form of cerebral palsy diagnosed.[1]Ataxic cerebral palsy is caused by damage to cerebellar structures, differentiating it from the other two forms of cerebral palsy, which are spastic cerebral palsy (damage to cortical motor areas and underlying white matter) and athetoid cerebral palsy (damage to basal ganglia).[2] Because of the damage to the cerebellum, which is essential for coordinating muscle movements and balance, patients with ataxic cerebral palsy experience problems in coordination, specifically in their arms, legs, and trunk. Ataxic cerebral palsy is known to decrease muscle tone.[3] The most common manifestation of ataxic cerebral palsy is intention (action) tremor, which is especially apparent when carrying out precise movements, such as tying shoe laces or writing with a pencil. This symptom gets progressively worse as the movement persists, causing the hand to shake. As the hand gets closer to accomplishing the intended task, the trembling intensifies which makes it even more difficult to complete.[4] Like all forms of CP, there is no "cure for" ataxic cerebral palsy. However there are a number of diverse treatments which together have been used to … Continue reading

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