Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. There has been an error retrieving the data. Please try again. Mechanical hearts Wolfram Zimmermann reviews heart muscle mechanics, mechanical loading in heart development and physiological loading in myocardial tissue engineering in this final review in thephysical influences on stem cellsseries. Endogenous primordial germ cells in chicken embryos can recover from the cytotoxic effects of busulfan treatment through promotion of the cell cycle, with implications for germ cell transplantation studies. The macrophages in ixmyelocel-T may have beneficial effects in atherosclerotic diseases as they influx cholesterol, remain anti-inflammatory in the face of lipid loading and inflammatory challenge, and display enhanced cholesterol efflux capabilities. Ixmyelocel-T, an expanded, autologous multicellular therapy cultured from bone marrow mononuclear cells, contains M2-like macrophages with clinical potential in tissue repair and regeneration. The feline amnion is a readily available source of amniotic epithelial cells (AECs) which may … Continue reading →

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek , meaning of the body), they can be found in juvenile as well as adult animals and human bodies. Scientific interest in adult stem cells is centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Unlike embryonic stem cells, the use of adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than destroyed human embryos. They have mainly been studied in humans and model organisms such as mice and rats. A stem cell possesses two properties: To ensure the safety of others, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). Symmetric division gives us a rise to two identical daughter cells, both endowed with stem cell properties, whereas asymmetric such division produces only one of those stem cells and a progenitor cell with limited self-renewal … Continue reading →

Adult stem cellSee somatic stem cell. AstrocyteA type of supporting (glial) cell found in the nervous system. BlastocoelThe fluid-filled cavity inside the blastocyst, an early, preimplantation stage of the developing embryo. BlastocystApreimplantationembryo consisting of a sphere made up of an outer layer of cells (thetrophoblast), a fluid-filled cavity (theblastocoel), and a cluster of cells on the interior (theinner cell mass). Bone marrow stromal cellsA population of cells found in bone marrow that are different from blood cells. Bone marrow stromal stem cells (skeletal stem cells)A multipotent subset of bone marrow stromal cells able to form bone, cartilage, stromal cells that support blood formation, fat, and fibrous tissue. Cell-based therapiesTreatment in which stem cells are induced to differentiate into the specific cell type required to repair damaged or destroyed cells or tissues. Cell cultureGrowth of cells in vitro in an artificial medium for research or medical treatment. Cell divisionMethod by which a single cell divides to create two cells. There are two main types of cell division depending on what happens to the chromosomes: mitosis and meiosis. ChromosomeA structure consisting of DNA and regulatory proteins found in the nucleus of the cell. The DNA in the nucleus is usually divided up … Continue reading →