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New stem cells go back further

Posted: Published on November 1st, 2013

Oct. 31, 2013 One of the obstacles to employing human embryonic stem cells for medical use lies in their very promise: They are born to rapidly differentiate into other cell types. Until now, scientists have not been able to efficiently keep embryonic stem cells in their pristine stem state. The alternative that has been proposed to embryonic stem cells -- reprogrammed adult cells called induced pluripotent stem cells (iPS cells) -- have similar limitations. Though these can differentiate into many different cell types, they retain signs of "priming," -- commitment to specific cell lineages. A team at the Weizmann Institute of Science has now taken a large step toward removing that obstacle: They have created iPS cells that are completely "reset" to the earliest possible state and maintained them in that state. Among other things, this research may, in the future, pave the way toward the ability to grow transplant organs to order. Since they were first created in 2006, iPS cells have been touted as an ethical and practical substitute for embryonic stem cells. They are made by inserting four genes into the genomes of such adult cells as skin cells. This turns back the developmental clock almost all … Continue reading

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A new model for organ repair

Posted: Published on November 1st, 2013

PUBLIC RELEASE DATE: 1-Nov-2013 Contact: B. D. Colen bd_colen@harvard.edu 617-413-1224 Harvard University Harvard Stem Cell Institute (HSCI) researchers have a new model for how the kidney repairs itself, a model that adds to a growing body of evidence that mature cells are far more plastic than had previously been imagined. After injury, mature kidney cells dedifferentiate into more primordial versions of themselves, and then differentiate into the cell types needing replacement in the damaged tissue. This finding conflicts with a previously held theory that the kidney has scattered stem cell populations that respond to injury. The research appears online in PNAS Early Edition. HSCI Kidney Diseases Program Leader Benjamin Humphreys, MD, PhD, a Harvard Medical School assistant professor at Brigham and Women's Hospital, was suspicious of the kidney stem cell repair model because his previous work suggested that all kidney cells have the capacity to divide after injury. He and his colleagues decided to test conventional wisdom by genetically tagging mature kidney cells in mice that do not express stem cell markers; the hypothesis being that the mature cells should do nothing or die after injury. The results showed that not only do these fully differentiated cells multiply, but they … Continue reading

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Genetics in Medicine – Nature

Posted: Published on November 1st, 2013

Welcome to Genetics in Medicine Genetics in Medicine, the official journal of the American College of Medical Genetics and Genomics, offers an unprecedented forum for the presentation of innovative, clinically relevant papers in contemporary genetic medicine. Stay tuned for cutting-edge clinical research in areas such as genomics, chromosome abnormalities, metabolic diseases, single gene disorders and genetic aspects of common complex diseases. Genetics in Medicine has launched a new online submission system. Submit your manuscript here. Instructions to Authors Here you will find all the information you need to submit your manuscript including details on word limits. Open Access Genetics in Medicine now offers authors the option to publish their articles with immediate open access upon publication. Find out more from our FAQs page. Volume 15, No 10 October 2013 ISSN: 1098-3600 EISSN: 1530-0366 2012 Impact Factor 5.560* Rank: 20/161 Genetics & Heredity Editor-in-Chief: James P. Evans, MD, PhD *2012 Journal Citation Report (Thomson Reuters, 2013) Genetics in Medicine now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from our FAQs … Continue reading

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Stem Cell Therapy & Stem Cell Treatment – Cell Therapy Center Emcell

Posted: Published on November 1st, 2013

Our Cell Therapy Center offers advanced patented methods of stem cell treatment for different diseases and conditions. The fetal stem cells we use are nonspecialized cells able to differentiate (turn) into any other cell types forming different tissues and organs. Fetal stem cells have huge potential for differentiation and proliferation and are not rejected by the recipients body more... Stem cell therapy has proven to be effective for organs and tissues restoration, and for fight against the incurable and obstinate diseases. We treat patients with various diseases, such as diabetes mellitus, multiple sclerosis, Parkinsons disease, Duchenne muscular dystrophy, cancer, blood diseases and many others, including rare genetic and hereditary diseases. Among our patients there are also people willing to undergo anti-aging treatment. Stem cell treatment allows for achieving effects that are far beyond the capacity of any other modern method more... For over 19 years, we have performed more than 7,500 transplantations of fetal stem cells to people from many countries, such as the USA, China, Italy, Germany, Denmark, UAE, Egypt, Russian Federation, Greece and Cyprus, etc. Our stem cell treatments helped to prolong life and improve life quality to thousands of patients including those suffering from the incurable diseases … Continue reading

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Stem Cell Quotes from Patients and Researchers

Posted: Published on November 1st, 2013

News Update Wednesday, 30 January 2013 15:32 "Now I can touch my mouth. Now I can put my finger in my ear. Now I can open my hands, I can lift them up. I can work on my computer. I can type. I can do many things with my hands." Gabi Iordache, SCI Stem Cell Patient What sort of gains can be had by Spinal Cord Injury patients receiving adult stem cell therapies? Let the patients tell you themselves. This month we're releasing a video containing eight StemCellsChina interviewees discussing the improvements they saw in their conditions following adult stem cell transplants. JavaScript is disabled! To display this content, you need a JavaScript capable browser. Patients here have all had between one and six cycles of treatment. They all had incomplete injuries. While not every patient sees the full spectrum of improvements discussed here, this video is intended to give an idea of what real patients have found through today's process. We'd like to thank all the patients for their courage in sharing their stories with us. Most of the patients featured in this video have patient experience interviews here at StemCellsChina. If you're interested in their stories, check out … Continue reading

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Understanding Nanomedicine – Nanotechnology

Posted: Published on November 1st, 2013

The use of nanotechnology in medicine offers some exciting possibilities. Some techniques are only imagined, while others are at various stages of testing, or actually being used today. Nanotechnology in medicine involves applications of nanoparticles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level (sometimes referred to as nanomedicine). Whatever you call it, the use of nanotechnology in the field of medicine could revolutionize the way we detect and treat damage to the human body and disease in the future, and many techniques only imagined a few years ago are making remarkable progress towards becoming realities. One application of nanotechnology in medicine currently being developed involves employing nanoparticles to deliver drugs, heat, light or other substances to specific types of cells (such as cancer cells). Particles are engineered so that they are attracted to diseased cells, which allowsdirect treatment of those cells. This technique reduces damage to healthy cells in the body and allows for earlier detection of disease. For example, nanoparticles that deliver chemotherapy drugs directly to cancer cells are under development. Tests are in progress for targeted delivery of chemotherapy drugs and their final … Continue reading

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Nanomedicine Fact Sheet – Genome

Posted: Published on November 1st, 2013

Nanomedicine Overview What if doctors had tiny tools that could search out and destroy the very first cancer cells of a tumor developing in the body? What if a cell's broken part could be removed and replaced with a functioning miniature biological machine? Or what if molecule-sized pumps could be implanted in sick people to deliver life-saving medicines precisely where they are needed? These scenarios may sound unbelievable, but they are the ultimate goals of nanomedicine, a cutting-edge area of biomedical research that seeks to use nanotechnology tools to improve human health. Top of page A lot of things are small in today's high-tech world of biomedical tools and therapies. But when it comes to nanomedicine, researchers are talking very, very small. A nanometer is one-billionth of a meter, too small even to be seen with a conventional lab microscope. Top of page Nanotechnology is the broad scientific field that encompasses nanomedicine. It involves the creation and use of materials and devices at the level of molecules and atoms, which are the parts of matter that combine to make molecules. Non-medical applications of nanotechnology now under development include tiny semiconductor chips made out of strings of single molecules and miniature … Continue reading

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Nanomedicine: Nanotechnology, Biology and Medicine – Journal …

Posted: Published on November 1st, 2013

The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases. In addition to bimonthly issues, the journal website (http://www.nanomedjournal.com) also presents important nanomedicine-related information, such as future meetings, meeting summaries, funding opportunities, societal subjects, public health, and ethical issues of nanomedicine. The potential scope of nanomedicine is broad, and we expect it to eventually involve all aspects of medicine. Sub-categories include synthesis, bioavailability, and biodistribution of nanomedicines; delivery, pharmacodynamics, and pharmacokinetics of nanomedicines; imaging; diagnostics; improved therapeutics; innovative biomaterials; interactions of nanomaterials with cells, tissues, and living organisms; regenerative medicine; public health; toxicology; point of care monitoring; nutrition; nanomedical devices; prosthetics; biomimetics; and bioinformatics. Article formats include Communications, Original Articles, Reviews, Perspectives, Technical and Commercialization Notes, and Letters to the Editor. We invite authors to submit original manuscripts in these categories. The journal website (http://www.nanomedjournal.com) also presents important nanomedicine-related information, such as future meetings, meeting summaries, funding opportunities, societal subjects, … Continue reading

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Nanomedicine, bionanotechnology | NanomedicineCenter.com

Posted: Published on November 1st, 2013

A lot of patients suffering from colon cancer might well present no symptoms or signs during the earliest stages of the condition. When symptoms do eventually present, they can be many and varied, and can very much depend upon the size of the affliction, how far it has spread and also its actual location. It might be that some symptoms that present are as a result of a condition other than cancer itself, ranging from irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and occasionally diverticulosis. Also, such problems as abdominal pain or swelling can be symptomatic of colon problems and may well require further investigation. You may also notice that, upon going to the lavatory, you have some blood in your stools, and this can be a symptom of cancer. Of course, having black poop doesnt ultimately mean that cancer is present. It can, however, also be indicative of other conditions and problems. For example, the kind of bright red blood that you may see on your toilet tissue could be as a result of hemorrhoids or anal fissures. It should also be remembered that various food items can also result in red poop, and these include beetroot and … Continue reading

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Nanomedicine, Volume 1: Basic Capabilities

Posted: Published on November 1st, 2013

Nanomedicine Book Site 1996-2013 Robert A. Freitas Jr. All Rights Reserved Nanomedicine, Volume IIA: Biocompatibility by Robert A. Freitas Jr. is now available in hardcover for $99 + shipping. Click here to purchase the book at Amazon.com or click here for information or to purchase the book directly from Landes Bioscience. Nanomedicine, Volume I: Basic Capabilities by Robert A. Freitas Jr. is now available in softcover for $89 + shipping. Click here for information or to purchase the book directly from Landes Bioscience. About Nanomedicine (the field) Molecular nanotechnology has been defined as the three-dimensional positional control of molecular structure to create materials and devices to molecular precision. The human body is comprised of molecules, hence the availability of molecular nanotechnology will permit dramatic progress in human medical services. More than just an extension of "molecular medicine," nanomedicine will employ molecular machine systems to address medical problems, and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine will have extraordinary and far-reaching implications for the medical profession, for the definition of disease, for the diagnosis and treatment of medical conditions including aging, and ultimately for the improvement and extension of natural human biological structure … Continue reading

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