Newswise PHILADELPHIA - The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate. The study, published in Nature Genetics, provides a broader view of genetic factors contributing to the disease and expands the scope of disease understanding to include new areas including the immune system, where a genetic overlap with other neurodegenerative diseases such as multiple sclerosis and Parkinson's disease was identified. "Human genetic studies are being used with increased frequency to validate new drug targets in many diseases. Here we greatly increased the list of possible drug target candidates for Alzheimers disease, finding as many new significant genes in this one study as have been found in the last 15 years combined," said co-senior author Gerard Schellenberg, PhD, director of the Alzheimers Disease Genetics Consortium (ADGC) and professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. "This international effort has given us new clues into the steps leading to and accelerating Alzheimer's disease. We can add these new genetic clues to what we already know and … Continue reading →

AURORA, Colo. (PRWEB) October 27, 2013 A study lead by scientists at University of Colorado Cancer Center and Dana-Farber Cancer Institute in Boston has uncovered a new sub-type of lung cancer. The study revealed a gene fusion - a forced merger of two normally separate genes that spurs the cells to divide rapidly causing non-small cell lung cancer. The study is published in the journal Nature Medicine. Scientists from CU Cancer Center and Dana-Farber collaborated on the finding. The group went a step beyond identifying the gene mutation, NTRK1, that drives some lung cancers. The scientists also showed the abnormal cells can be targeted by several drugs. Whether a drug is already is in clinical trials, or already approved for another cancer, or just sitting on the pharma shelf somewhere, many drugs exist that turn off these candidate genes," said Robert C. Doebele, MD, PhD, the studys senior author and investigator at the CU Cancer Center. Doebele found Array BioPharma in Boulder, Colo. happened to have several compounds specific to NTRK1. The group showed that mutated NRTK1 genes in cells treated with drug candidate ARRY-470 and others was effectively turned off. The drug blocks a protein causing cancer cells to … Continue reading →

PUBLIC RELEASE DATE: 27-Oct-2013 Contact: Kim Menard kim.menard@uphs.upenn.edu 215-662-6183 University of Pennsylvania School of Medicine PHILADELPHIA - The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate. The study, published in Nature Genetics, provides a broader view of genetic factors contributing to the disease and expands the scope of disease understanding to include new areas including the immune system, where a genetic overlap with other neurodegenerative diseases such as multiple sclerosis and Parkinson's disease was identified. "Human genetic studies are being used with increased frequency to validate new drug targets in many diseases. Here we greatly increased the list of possible drug target candidates for Alzheimer's disease, finding as many new significant genes in this one study as have been found in the last 15 years combined," said co-senior author Gerard Schellenberg, PhD, director of the Alzheimer's Disease Genetics Consortium (ADGC) and professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. "This international effort has given us new clues into the steps leading to and accelerating Alzheimer's … Continue reading →

stem cell therapy treatment for autism from united kingdom by dr alok sharma, mumbai, india amazing improvement seen in just 1 months after stem cell therapy treatment for autism from united kingdom by dr alok sharma, mumbai, india. After Stem Cell ... By: Neurogen Brain and Spine Institute … Continue reading →

Washington, Oct. 28 : A team of doctors and scientists used an innovative stem cell technique to create neurons in a lab dish from skin scrapings of patients who have Lou Gehrig's disease. The researchers inserted molecules made of small stretches of genetic material, blocking the damaging effects of a defective gene and, in the process, providing "proof of concept" for a new therapeutic strategy - an important step in moving research findings into clinical trials. The study is believed to be one of the first in which a specific form of Lou Gehrig's disease, or amyotrophic lateral sclerosis, was replicated in a dish, analyzed and "treated," suggesting a potential future therapy all in a single study. Robert H. Baloh, MD, PhD, director of Cedars-Sinai's Neuromuscular Division in the Department of Neurology and director of the multidisciplinary ALS Program, said that in a sense, this represents the full spectrum of what we are trying to accomplish with patient-based stem cell modeling. He said that it gives researchers the opportunity to conduct extensive studies of a disease's genetic and molecular makeup and develop potential treatments in the laboratory before translating them into patient trials. Laboratory models of diseases have been made … Continue reading →

Phoenix, Arizona (PRWEB) October 28, 2013 The top Phoenix stem cell clinic, Arizona Pain Specialists, is now offering multiple stem cell therapy options for patients to avoid joint replacement surgery. The procedures offered are all low risk and outpatient procedures with the Board Certified and Award Winning Phoenix pain doctors at the clinics. Call (602) 507-6550 for more information and scheduling. The Arizona Pain Stem Cell Institute offers multiple different types of regenerative medicine procedures with the potential to repair joint damage and relieve pain. These include multiple different types of stem cell therapy including bone marrow, adipose (fat) or amniotic derived stem cell injections. Small published studies have shown impressive success rates at helping patients achieve pain relief and increase functional abilities. With well over a million joint replacements being performed in the US every year, procedures that provide a chance to avoid or significantly delay the procedure are welcome. All of the stem cell injection procedures are outpatient and very low risk. The bone marrow and fat are harvested from the patients themselves, so the risk is very low for infection or rejection. Amniotic derived stem cell injections have been used over 10,000 times to date for numerous … Continue reading →

Orange, California (PRWEB) October 28, 2013 The premier stem cell therapy clinic on the West Coast, TeleHealth, is now offering regenerative medicine options for patients with rotator cuff disorders. The stem cell treatments often provide pain relief and help patients avoid the need for surgery. For more information and scheduling, call (888) 828-4575. Millions of Americans suffer from shoulder pain due to rotator cuff bursitis, tendonitis or tears. For an unfortunate few, conventional treatments are not able to alleviate the pain and surgery becomes necessary. The Board Certified doctors at TeleHealth are now offering nonoperative stem cell injection therapy as an outpatient to help patients obtain relief and repair. The procedures involved options for bone marrow or fat derived stem cell injections along with platelet rich plasma therapy. The procedures are very low risk since the substance injected is actually harvested from the patient and then immediately processed prior to injection into the problematic shoulder. Small published studies have been showing the benefits of stem cell therapy and PRP treatment for rotator cuff disorders. The injections can help athletes get back to competition quicker and avoid the months of rehab necessary after an arthroscopic procedure. Some of the procedures are … Continue reading →

LOS ANGELES--(BUSINESS WIRE)-- Life Stem Genetics Inc., an emerging innovator in the advancement of Adult Stem Cell therapy, is pleased to announce that Matthew Sullivan, COO of global heath products company Asana International, and Shahab Bakhtyar, an independent medical business consultant with global experience, have joined Life Stems Executive Advisory Board. Established earlier this year, the Executive Advisory Board has become a cornerstone of Life Stems global stem-cell growth model by actively retaining influential business leaders with broad backgrounds in corporate development and finance in our targeted industries with a focus on business expansion into Canada, Europe, Asia, and the Middle East. Matthew Sullivan, BA, MBA, is a corporate finance specialist who has worked with numerous early-stage and well-established companies in operations as well as strategic and financial planning. Matthews background is in venture capital and business analysis. His role has ranged from business planning/implementation, M&A, market analysis to operational implementation. He is currently COO of Asana International, a global health products company, CFO of Kat Gold Holdings, a publicly traded gold production and exploration company based in Ghana, and CFO of Travelvu, a business that places smart devices in hotel rooms. Matthew holds a Bachelor of Arts degree from … Continue reading →

Current ratings for: 'Sex drive slows' after stem cell transplantation Ratings require JavaScript to be enabled. New research suggests that complications and preparative procedures linked to stem cell transplantation may lead to sexual dysfunction in both men and women. This is according to a study published in the journal Blood. Researchers from the City of Hope Cancer Research Hospital in Duarte, California, say that graft-versus-host disease (GVHD) - a complication that can arise after stem cell transplantation (SCT) when donor cells attack recipient cells - could be a cause of diminished sexual health. Furthermore, they found a link between diminished sexual health in men and total body radiation - a preparation treatment administered prior to the SCT procedure. Stem cell transplantation is a commonly used and effective form of treatment for those suffering from blood cancers, such as leukemia, lymphoma and myeloma. The procedure involves taking stem cells either from a patient's own blood or bone marrow, or a matched donor, and replacing the patient's damaged cells with healthy cells. The researchers note that previous studies have indicated that after this procedure, while a person may physically recover, their sexual health may be slower in returning to normal. To look … Continue reading →