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Laser tomography aids 'mass production' of stem cells

Posted: Published on October 9th, 2013

A German government-funded research project is using laser tomography to help scale-up stem cell production for anticipated new therapies. Work on the Ministry of Education and Research (BMBF)-backed Ultrasensitive Verification and Manipulation of Cells and/or Tissue and their molecular Substances started in July and will receive 4.1million over the course of three years. Central to the project is a technique known as scanning laser optical tomography (SLOT), developed and patented by Laser Zentrum Hannover, while other project partners with optics expertise include the advanced microscopy specialist LaVision BioTec and lens maker Sill Optics. The SLOT technique is used to monitor cell cultures consisting of so-called pluripotent stem cells (hPSC). Once isolated from an embryo, these cells have the ability to turn into virtually any cell type. In the new TOMOSphere project, SLOT will, for the first time, be used to monitor quantitatively the absolute number of cells in cultured, endogenous groups. The results are expected improve understanding of the physiology of hPSC and other stem cells, as well continuous control of their characteristics. Light combination LZH scientists have previously used SLOT to generate optical images similar to those produced by a familiar X-ray computed tomography (CT) scanner. Having already created … Continue reading →

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Sangamo BioSciences Announces Presentation At the 2013 Stem Cell Meeting on the Mesa

Posted: Published on October 9th, 2013

RICHMOND, Calif., Oct. 7, 2013 /PRNewswire/ -- Sangamo BioSciences, Inc. (SGMO) announced today that Elizabeth Wolffe, Ph.D., Sangamo's senior director of corporate communications, will give a company presentation at the 3rd Annual Regen Med Partnering Forum, part of the Stem Cell Meeting on the Mesa to be held October 14-16, 2013, in La Jolla, CA. (Logo: http://photos.prnewswire.com/prnh/20130102/SF35903LOGO) Organized by the Alliance for Regenerative Medicine (ARM), the California Institute for Regenerative Medicine (CIRM) and the Sanford Consortium for Regenerative Medicine, the 2013 Stem Cell Meeting on the Mesa is a three-day conference aimed at bringing together members of the regenerative medicine industry with the scientific research community to advance stem cell science into cures. The Regen Med Partnering Forum, held October 14 &15 at the Estancia La Jolla Hotel, is the only partnering meeting organized specifically for the regenerative medicine and advanced therapies industry. The following are specific details regarding Sangamo's presentation at the conference: Event: Regen Med Partnering Forum 2013 Stem Cell Meeting on the Mesa Date: October 14, 2013 Time: 5:15 p.m. Location: Estancia La Jolla Hotel & Spa, 9700 North Torrey Pines Road, La Jolla, CA 92037 A live video webcast of all company presentations will be available … Continue reading →

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BrainStorm to Present at Multiple Scientific Conferences in October

Posted: Published on October 9th, 2013

NEW YORK & PETACH TIKVAH, Israel--(BUSINESS WIRE)-- BrainStorm Cell Therapeutics (BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that it is presenting at multiple scientific conferences this month. Israel Stem Cell Society 5thInternational Stem Cell Meeting Professor Dani Offen, BrainStorms Chief Scientific Advisor, will present at the 5th International Stem Cell Meeting sponsored by the Israel Stem Cell Society, October 8th-9th in Jerusalem. Prof. Offen will be making a poster presentation on October 8th at 17:30, and an oral presentation on Oct 9th at 17:15. Israel Braintech 2013 Professor Dani Offen, BrainStorms Chief Scientific Advisor, will present at the Israel Braintech 2013 Meeting, October 14th-15th in Tel Aviv. The meeting is sponsored by Israel Brain Technologies (IBT), a non-profit organization inspired by the vision of Israeli President Shimon Peres to promote Israels neurotechnology innovation hub. Prof. Offens oral presentation will be part of the session entitled: A Spotlight on the Israeli NeuroTech Industry, October 15th at 12:15. Israel A.L.S Research Association Professor Dimitrios Karussis, Principal Investigator of BrainStorms clinical trials at Jerusalems Hadassah Medical Center, will present at the Israel A.L.S Research Association (IsrA.L.S) Conference, From the Lab to the Clinic: An Overview of … Continue reading →

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BrainStorm to Present at 2013 Stem Cell Meeting on the Mesa Organized by CIRM, ARM and Sanford Consortium

Posted: Published on October 9th, 2013

NEW YORK & PETACH TIKVAH, Israel--(BUSINESS WIRE)-- BrainStorm Cell Therapeutics (BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that Dr. Adrian Harel, Director R&D, will present at the 3rd Annual Regen Med Partnering Forum, part of the Stem Cell Meeting on the Mesa to be held October 14-16 in La Jolla, CA. Organized by the Alliance for Regenerative Medicine (ARM), the California Institute for Regenerative Medicine (CIRM) and the Sanford Consortium for Regenerative Medicine, the 2013 Stem Cell Meeting on the Mesa is a three-day conference aimed at bringing together senior members of the regenerative medicine industry with the scientific research community to advance stem cell science into cures. The Regen Med Partnering Forum, held October 14 & 15 at the Estancia La Jolla Hotel, is the only partnering meeting organized specifically for the regenerative medicine and advanced therapies industry. The meeting also features a nationally recognized Scientific Symposium, held October 16 at the Salk Institute for Biological Studies, showcasing leading academic research in the field of regenerative medicine. Combined, these meetings attract over 800 attendees from around the globe, fostering key partnerships through one-on-one meetings while also highlighting clinical and commercial progress in … Continue reading →

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Progress in Stem Cell Research based on SLOT

Posted: Published on October 9th, 2013

07.10.2013 - (idw) Laser Zentrum Hannover e.V. The Laser Zentrum Hannover (LZH e.V.) is currently active in a project dealing with the tomographic monitoring of 3-D cell cultures consisting of pluripotent stem cells (hPSC). The Laser Zentrum Hannover (LZH e.V.) is currently active in a project dealing with the tomographic monitoring of 3-D cell cultures consisting of pluripotent stem cells (hPSC). The goal of the collaborative research project is, for the first time, to use Scanning Laser Optical Tomography (SLOT) for non-invasive, direct, quantitative compilation of the absolute number of cells in cultured, endogenous cell groups. The results of the project TOMOSphere should bring a better understanding of the physiology of hPSC and other stem cells, as well as a continuous control of their characteristics, making decisive progress in therapeutic concepts possible. For the investigations, SLOT-technology, which was developed and patented at the LZH, was used for the first time for the temporally and spatially resolved observation of native or fixed cells in three-dimensional aggregate structures. Knowledge gained from using this process can be used to classify and later to sort the aggregates, for example concerning heterogeneity of the cell structure, possible cyst formation, or the deposition of extracellular matrixes. … Continue reading →

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Cancer Genetics, Inc. Will Open Precision Medicine Conference With Keynote Presentation

Posted: Published on October 9th, 2013

RUTHERFORD, N.J., Oct. 8, 2013 (GLOBE NEWSWIRE) -- Cancer Genetics, Inc. (CGIX) ("CGI" or the "Company"), an emerging leader in DNA-based cancer diagnostics that personalizes the clinical management of difficult-to-diagnose cancers, today announced its vice president of R&D, Jane Houldsworth, Ph.D., will provide the opening keynote presentation for the "Realizing the Potential of Precision Medicine" conference on October 9, 2013 at 1:00 pm ET. "The use of genetic information to improve diagnosis, treatment and patient outcomes is the very foundation of precision medicine," stated Panna Sharma, CEO of CGI. "This conference brings together key industry thought leaders to provide attendees with insights on how to apply precision medicine in the clinical setting. Participating companies include major players in genetics, such as Illumina and Luminex. Other participants include Weill Cornell Medical College, New-York Presbyterian Hospital and other key institutions that serve the needs of oncology patients. For CGI to have the honor of opening this conference is a testament to our leadership position in the rapidly evolving field of precision medicine." Dr. Houldsworth's keynote "From Vision to Reality, the Cancer Genetics Complete Experience," will use CGI's Complete Programs(TM) as a case study to strategize the introduction and successful licensure of molecular … Continue reading →

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Blood vessel cells can repair, regenerate organs, say Weill Cornell scientists

Posted: Published on October 9th, 2013

Public release date: 8-Oct-2013 [ | E-mail | Share ] Contact: Sarah Smith sas2072@med.cornell.edu 646-317-7401 Weill Cornell Medical College NEW YORK (October 8, 2013) -- Damaged or diseased organs may someday be healed with an injection of blood vessel cells, eliminating the need for donated organs and transplants, according to scientists at Weill Cornell Medical College. In studies appearing in recent issues of Stem Cell Journal and Developmental Cell, the researchers show that endothelial cells -- the cells that make up the structure of blood vessels -- are powerful biological machines that drive regeneration in organ tissues by releasing beneficial, organ-specific molecules. They discovered this by decoding the entirety of active genes in endothelial cells, revealing hundreds of known genes that had never been associated with these cells. The researchers also found that organs dictate the structure and function of their own blood vessels, including the repair molecules they secrete. Together, the studies show that endothelial cells and the organs they are transplanted into work together to repair damage and restore function, says the study's lead investigator, Shahin Rafii, M.D., a professor of genetic medicine and co-director of the medical college's Ansary Stem Cell Institute and Tri-SCI Stem Center. When … Continue reading →

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Proposed Treatment To Fix Genetic Diseases Raising Ethics Issues

Posted: Published on October 9th, 2013

This micrograph shows a single mitochondrion (yellow), one of many little energy factories inside a cell. The federal government is considering whether to allow scientists to take a controversial step: make changes in some of the genetic material in a woman's egg that would be passed down through generations. Mark Sauer of the Columbia University Medical Center, a member of one of two teams of U.S. scientists pursuing the research, calls the effort to prevent infants from getting devastating genetic diseases "noble." Sauer says the groups are hoping "to cure disease and to help women delivery healthy normal children." But the research also raises a variety of concerns, including worries it could open the door to creating "designer babies." The Food and Drug Administration has scheduled an Oct. 22 hearing to consider the issues. Specifically, the research would create an egg with healthy mitochondrial DNA (mtDNA). Unlike the DNA that most people are familiar with the 23 pairs of human chromosomes that program most of our body processes mtDNA is the bit of genetic material inside mitochondria, living structures inside a cell that provide its energy. Scientists estimate that one in every 200 women carries defects in her mtDNA. Between … Continue reading →

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Dr. Murray Feingold: Genetic testing

Posted: Published on October 9th, 2013

I recently attended a symposium concerning the effect that new genetic testing can have on the medical care that you receive. This isnt five or ten years down the road but it is taking place today. Just from a blood sample, your approximately 23,000 genes can be tested for gene mutations that cause diseases such as cancer, heart disease, intellectual and physical disabilities, and the list goes on and on. For example, why do some individuals have a strong family history of developing certain types of cancers? Tests called Whole Exome Sequencing (WES) or Whole Genome Sequencing (WGS), can determine if there is a mutation in certain cancer causing genes that can be passed on to family members. These tests can also provide good news by determining that an individual does not have the gene causing cancer. Then there is Personalized Medicine. Why is it that when 100 patients have the same disease and are treated with the same medication, a certain percentage will not respond to the treatment or will develop a serious reaction to the medication? Many times it is due to the individuals genetic make-up. By knowing that patients will not respond to certain medications because of … Continue reading →

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Smartphone app brings genetic analysis to the palm of your hand

Posted: Published on October 9th, 2013

Public release date: 8-Oct-2013 [ | E-mail | Share ] Contact: George Hunka ghunka@aftau.org 212-742-9070 American Friends of Tel Aviv University Until now, understanding and using genetic information has depended on the scientists and doctors who do the testing. No longer. Now, software developed by researchers at Tel Aviv University is putting the power of genetic information in the hands of the people. GeneG, a smartphone app and associated web site created by Dr. Noam Shomron at TAU's Faculty of Medicine allows individuals to access and analyze their genome at any time. After undergoing whole genome sequencing, users can upload their data to the GeneG website for analysis. The results are available via the GeneG app on mobile devices. "For the first time you can take your genome home and look at it whenever you want," says Shomron. "We are giving you eyes to peer into your genetics." And as new analytical tests are developed, you can apply them right away. TAU graduate students Ofer Isakov and Gershon Celniker worked under Shomron to develop the software, which is to be released to physicians in October ahead of a public release. More information about the project can be found at http://www.geneg.org/. … Continue reading →

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