Stem cells delivered by patch effective in repairing cardiac damage weeks after heart attack occurs A new study released in STEM CELLS Translational Medicine shows that in rats, treating a heart attack with stem cells even weeks after the attack occurred can halt deterioration and help the heart regenerate itself. In addition, the doctors delivered the cells using a patch that resulted in a higher survival rate for the stem cells and more of them migrating into the damaged tissue, where they went to work creating new blood vessels. The team, from the University of Louisvilles Cardiovascular Innovation Institute (Louisville, KY), had previously shown in rat studies that stem cell treatment immediately following an attack aided recovery by improving blood flow in the smallest vessels of the heart. This time the goal was to determine if the treatment was still effective if applied later in time. We also were seeking a more efficient delivery method for the stem cells by utilizing the heart patch model. Most studies employing an injection of stem cells encounter swift cell death or cell washout from the target tissue, said Amanda LeBlanc, Ph.D., who led the investigation along with Stuart Williams, Ph.D., the institutes executive … Continue reading
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