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Recent Findings from M. Nishikawa and Co-Researchers Yields New Information on Stem Cells

Posted: Published on August 23rd, 2013

By a News Reporter-Staff News Editor at Veterinary Week -- Research findings on Stem Cell Research are discussed in a new report. According to news originating from North Hills, California, by VerticalNews correspondents, research stated, "Successful derivations of specific neuronal and glial cells from embryonic stem cells have enormous potential for cell therapies and regenerative medicine. However, the low efficiency, the complexity of induction method, and the need for purification represent obstacles that make their application impractical." Our news journalists obtained a quote from the research, "In this study, we found that PDGFR alpha(+) cells derived from mouse embryonic stem cells (mESC) can serve as a useful source from which to induce cells that express gamma-aminobutyric-acid (GABA)-releasing (GABAergic) neuronal markers. PDGFR alpha(+) cells were induced from mESC on collagen IV-coated plates in mesenchymal stem cell (MSC) culture medium with limited exposure to retinoic acid, sorted by fluorescence-activated cell sorter and maintained in MSC culture medium containing Y-27632, a Rho-associated kinase inhibitor. We found that supplementation of vascular endothelial growth factor, fibroblast growth factor-basic, and sodium azide (NaN3) to MSC culture medium effectively differentiated PDGFR alpha(+) cells into cells that express GABAergic neuronal markers, such as Pax2, Dlx2, GAD67 NCAM, and … Continue reading →

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Campaign launched to help brave Connor

Posted: Published on August 23rd, 2013

Connor Olsen, four, with mum and dad Georgina and Wayne, from Westgate. He was diagnosed with a rare muscular wasting disease Duchenne muscular dystrophy in March 2013 and his family and the Thanet community are rallying to support the Caring For Connor Campaign towards the best possible treatment for him by Mary Louis mlouis@thekmgroup.co.uk Little Connor Olsen is an active lad who loves cars. He is earnest and chatty with twinkly blue eyes. His favourite pastimes include running and swingball. He has no idea about the rare muscle wasting disease attacking his body. Nor has Connor, just four, from Westgate, so far been noticeably affected by his Duchenne Muscular Dystrophy, only diagnosed in March. He has a tendency to fall down rather too often, tires easily and finds stairs a challenge. The terrible statistical prognosis is that he will be in a wheelchair by the age of 10 and dead by 20. The goal is to give Connor the best possible chance through a fighting fund for the latest treatment. Go here to read the rest: Campaign launched to help brave Connor … Continue reading →

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Earnings & Deals — Gazette.Net

Posted: Published on August 23rd, 2013

Supernus Pharmaceuticals of Rockville received final approval from the U.S. Food and Drug Administration, effective Aug. 16, for Trokendi XR, a once-daily extended release formulation of topiramate for the treatment of epilepsy. The company expects to launch the product and for it to be available in pharmacies over the next few weeks. The company reported that revenue for the second quarter was $281,000, up from $91,000 a year earlier. Its net loss widened to $27.4 million from a loss of $10 million a year earlier. Selling, general and administrative expenses almost tripled to $12.2 million due to increased sales and marketing costs related to the commercial launch of Oxtellar XR and the planned launch of Trokendi XR. Rockville biotechnology company MacroGenics has met a milestone with its first patient dosed in a Phase 1 trial of a treatment for cancer tumors called MGA271, triggering a $10 million payment to the company from partner Les Laboratoires Servier. MacroGenics plans to enroll 45 patients within three cohort groups and expects to complete the Phase 1 trial in 2014. MGA271 has significant potential to treat a variety of solid tumors, said Scott Koenig, president and CEO of MacroGenics, in a statement. Famous Daves … Continue reading →

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Treating strokes within 90 minutes leads to better recovery, study shows

Posted: Published on August 23rd, 2013

Would you be able to tell if you or someone you know were having a stroke? People who are able to recognize their stroke symptoms and receive treatment within 90 minutes of their onset may experience a greatly reduced risk for permanent disability, according to a new study from the journal Stroke. Strokes are the fourth leading cause of death in the United States and the number one cause of disability, according to the American Heart Association. When a person experiences a stroke, time is of the essence. The faster doctors are able to administer clot-busting drugs, the sooner blood flow to the brain can be restored, preventing permanent damage. In order to assess the best window of time for treatment, researchers from Helsinki University Central Hospital in Finland studied 6,800 stroke patients at 10 stroke centers in Europe over the course of 14 years. They discovered that people suffering from mild to moderate strokes were less likely to experience disabling side effects if they were treated with clot-busting drugs within 90 minutes of first experiencing symptoms. Dr. Larry B. Goldstein, professor of neurology and director at the Duke Comprehensive Stroke Center in North Carolina, noted that while the window … Continue reading →

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Twins Are First Babies Born Using Tricare IVF Benefit

Posted: Published on August 23rd, 2013

Ryan and Alana Matayka are just five-months-old, but they've already made history. The twins are the first children born via in vitro fertilization that was paid for by a new Tricare benefit. The benefit covers infertility treatment for severely injured service members. The twins' father, Army Staff Sgt. Ed Matayka, lost both legs above the knee and injured his spinal cord when the vehicle in which he was riding hit a roadside bomb in Afghanistan on July 2, 2010. Little Ryan Matayka is named after the driver of the vehicle, Spc. Ryan Grady, who was killed in the attack that injured Ed Matayka. In the past, Tricare never covered assisted reproductive technologies like IVF. However, as of April 3, 2012, Tricare has made an exception for certain cases: Assisted reproductive services may be available to service members who have sustained serious or severe illness or injury while on active duty that led to the loss of their natural reproductive ability including (but not limited to) those with neurological, physiological, and/or anatomical injuries. Ed Matayka's wife Karen underwent in vitro fertilization at the San Antonio Military Medical Center, and became pregnant with the twins in September 2012. Maria Guerrero, with the … Continue reading →

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Receptor may aid spread of Alzheimer's and Parkinson's in brain

Posted: Published on August 23rd, 2013

Aug. 23, 2013 Scientists at Washington University School of Medicine in St. Louis have found a way that corrupted, disease-causing proteins spread in the brain, potentially contributing to Alzheimer's disease, Parkinson's disease and other brain-damaging disorders. The research identifies a specific type of receptor and suggests that blocking it may aid treatment of theses illnesses. The receptors are called heparan sulfate proteoglycans (HSPGs). "Many of the enzymes that create HSPGs or otherwise help them function are good targets for drug treatments," said senior author Marc I. Diamond, MD, the David Clayson Professor of Neurology. "We ultimately should be able to hit these enzymes with drugs and potentially disrupt several neurodegenerative conditions." The study is available online in the Proceedings of the National Academy of Sciences. Over the last decade, Diamond has gathered evidence that Alzheimer's disease and other neurodegenerative diseases spread through the brain in a fashion similar to conditions such as mad cow disease, which are caused by misfolded proteins known as prions. Proteins are long chains of amino acids that perform many basic biological functions. A protein's abilities are partially determined by the way it folds into a 3-D shape. Prions are proteins that have become folded in … Continue reading →

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FDA Warns Against Alternative Autism Therapy

Posted: Published on August 23rd, 2013

The Food and Drug Administration is warning consumers that a therapy often marketed for treating autism, cerebral palsy and other conditions is unproven and may endanger their health. Federal regulators said Thursday that contrary to many claims on the Internet, hyperbaric oxygen therapy is not clinically proven to cure or effectively treat the developmental disorders and many other conditions. Patients may incorrectly believe that these devices have been proven safe and effective for uses not cleared by the FDA, which may cause them to delay or forgo proven medical therapies, said Nayan Patel, a biomedical engineer at the FDAs anesthesiology devices branch. In doing so, they may experience a lack of improvement and/or worsening of their existing conditions. Despite limited research, hyperbaric oxygen therapy has become a popular alternative treatment for autism and cerebral palsy. For the therapy, individuals spend time in a pressurized chamber allowing the lungs to take in as much as three times the normal amount of oxygen. Hyperbaric oxygen therapy is FDA approved for thirteen different uses including the treatment of thermal burns, carbon monoxide poisoning and decompression sickness thats sometimes experienced by divers. But, in issuing the consumer alert this week, regulators listed more than … Continue reading →

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Brain injury patients fight for therapy time and money

Posted: Published on August 23rd, 2013

The way it's been explained to her family, 20-year-old Ellie Cizek has about 18 months to regain the memory and thinking skills she lost on the Colorado ski slopes in January, when she glanced off a chairlift post and slammed headfirst into a tree. So imagine their frustration this spring when, only four months into her recovery from a traumatic brain injury, her health insurer denied further care at a specialized rehabilitation center in Omaha and the family had to bring Cizek home to St. Paul. "Insurance is pretty mean to brain-injured patients," Cizek's sister, Josie, said recently as the family prepared a fundraiser to pay for her care. It's a common refrain for patients like Cizek -- and a growing concern in the United States, where the concussive force of sport injuries, car crashes and other accidents causes 1.7 million traumatic brain injuries each year, including 90,000 severe enough to cause long-term disability. Doctors often recommend cognitive rehabilitation -- a set of therapies to retrain patients' brains and restore lost brainpower -- beyond what insurance companies cover. Insurers face the dilemma of trying to hold the line on therapy costs, especially if it appears that patients have reached a … Continue reading →

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Newly Diagnosed With MS? What You Should Do

Posted: Published on August 23rd, 2013

By Robin Westen No one knows exactly how many people have Multiple Sclerosis (MS), but experts think there are currently 250,000 to 350,000 people in the United States diagnosed with the disease. This means every week approximately 200 people learn they have it, and studies show that the rate of the disease has been steadily increasing. If youre diagnosed with MS, here are the first steps to take: Know the facts: There are lots of myths around MS and sometimes misconceptions can be scarier than the facts. MS is a chronic autoimmune disease that affects the central nervous system. Its caused when the immune system attacks the myelin, the protective insulation covering nerve fibers in the brain and spinal cord. Myelin is destroyed and replaced by scars of hardened tissue (lesions), and some underlying nerves are damaged. But MS is almost never fatal; many people diagnosed with the disease never need a wheelchair. Be sure of your diagnosis: Since MS isnt easy to diagnose, getting a definite diagnosis takes time. Various tests may be used. Besides a neurological exam, you might also have magnetic resonance imaging (MRI), evoked potentials (EP), and spinal fluid analysis (spinal tap). Understand the symptoms: No … Continue reading →

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Spin doctors: Identifying and treating human balance disorders

Posted: Published on August 23rd, 2013

By Shane Huntington Neurologist Dr David Szmulewicz describes the human balance system, and whats going on in our brains and ears when we experience vertigo. SHANE HUNTINGTON I'm Dr Shane Huntington. Thanks for joining us. Most of us at some stage in our lives attempted to achieve the difficult task of taking a doll or action figure and standing it upright. At first glance, it would seem that these simple miniatures of the human form should stand as easily as we do but sadly they too easily topple over. Of course the reason for this poor performance is because these replicas lack something that we possess, namely a sophisticated balance system. The human body and that of many other animals has evolved a system of balance that is more sophisticated than anything we are yet able to model or reconstruct in the lab. Our balance system enables us to manage extraordinary acrobatic acts and, on a simpler scale, safely perform the necessary movements of day to day life. But what happens when this system fails? How do we react to a lack of balance and what can we do to resolve problems of this type? To discuss the balance system … Continue reading →

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