EXTON, Penn.--(BUSINESS WIRE)-- Fibrocell Science, Inc. (NYSE MKT:FCSC), announced today positive results from a study demonstrating a potential mechanism for converting research-grade adult skin cells into clinical grade induced pluripotent stem (iPS) cells. The study, entitled Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status will be published in the peer-reviewed journal Stem Cell Research and Therapy. The provisional paper is available online at http://stemcellres.com/content/4/4/87/abstract. The study was conducted under the guidance of James Byrne, Ph.D., assistant professor, UCLA Department of Molecular and Medical Pharmacology, at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. In addition to providing proof of concept for this reprogramming method of converting adult skin cells to iPS cells, the study confirmed that researchers can effectively remove unwanted non-human contaminants from stem cell populations derived under research-grade conditions. A variety of tests were used to determine whether the converted stem cell population was viable, expressed markers identifying them as stem cells, was free of microorganisms and no longer expressed non-human contaminants. Positive test results proved that these stem cells were free of unwanted non-human factors. The iPS cells generated from the study were also … Continue reading
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